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Plrg1
Gene Detail
Symbol

Name
ID
Plrg1
pleiotropic regulator 1, PRL1 homolog (Arabidopsis)
MGI:1858197
Synonyms
Tango4
Feature Type
protein coding gene
Genetic Map
Chromosome 3
36.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:83055522-83072355 bp, + strand
From VEGA annotation of GRCm38

  16834 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2004  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLRG1
Gene Tree: Plrg1

Human
homologs
PLRG1, pleiotropic regulator 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5356
neXtProt AC: NX_O43660

Human Synonyms: Cwc1, PRL1, PRP46, PRPF46, TANGO4

Human Chr (Location): 4q31.2-q32.1; chr4:154534997-154550433 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality by E1.5.
 
Interactions
Plrg1 interacts with 108 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process mRNA processing, mRNA splicing, via spliceosome, ...
Component catalytic step 2 spliceosome, Cul4-RING E3 ubiquitin ligase complex, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (84)    Tissues (48)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 56
Northern blot 28
cDNA source data(70)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plrg1 ; ZFIN plrg1    NEW 
Molecular
reagents
All nucleic(71) cDNA(70) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029843 (Evidence)
Ensembl Gene Model ENSMUSG00000027998 (Evidence)
Entrez Gene 53317 (Evidence)
UniGene 286349
DFCI TC1578112, TC1601177
DoTS DT.101147335, DT.101392021, DT.97363249, DT.97363253
NIA Mouse Gene Index U003367
Consensus CDS Project CCDS17433.1
International Mouse Phenotyping Consortium Status Plrg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029843 VEGA Gene Model | MGI Sequence Detail 16834 C57BL/6J ±  kb
transcript OTTMUST00000074056 VEGA | MGI Sequence Detail 1851 Not Applicable 
polypeptide OTTMUSP00000038421 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(169 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012881 pleiotropic regulator 1
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)
Other
accession IDs
MGI:2139608, MGI:2140075

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory