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Tslp
Gene Detail
 Symbol
Name
ID
Tslp
thymic stromal lymphopoietin
MGI:1855696
Feature Type protein coding gene
Genetic Map
Chromosome 18
18.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr18:32815383-32819799 bp, + strand
From NCBI annotation of GRCm38

  4417 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:81957  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Tslp

Human
homologs
Human Homolog TSLP, thymic stromal lymphopoietin
NCBI Gene ID 85480
neXtProt AC  NX_Q969D9
Human Chr (Location)  5q22.1; chr5:111070080-111078024 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit resistance to MC903-induced atopic dermatitis. Mice homozygous for another knock-out allele exhibit altered airway inflammation induced by LPS.
 
Interactions
Tslp interacts with 99 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Component extracellular region, extracellular space
Function cytokine activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (8)    Tissues (2)   
Theiler Stages: 26
Assay TypeResults
Immunohistochemistry 4
RT-PCR 4
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000024379 (Evidence)
Entrez Gene53603 (Evidence)
UniGene143716
DFCITC1593281, TC1619947
DoTSDT.91334620, DT.97335320
NIA Mouse Gene IndexU018525
PDB4NN5, 4NN6, 4NN7
Consensus CDS ProjectCCDS29121.1
International Mouse Knockout Project StatusTslp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 53603 NCBI Gene Model | MGI Sequence Detail 4417 C57BL/6J ±  kb
transcript NR_033206 RefSeq | MGI Sequence Detail 1146 C57BL/6 
polypeptide Q9JIE6 UniProt | EBI | MGI Sequence Detail 140 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(3) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000016730 thymic stromal lymphopoietin
Graphical View of Protein Domain Structure
References (Earliest) J:33087 Ray RJ, et al., Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro. Eur J Immunol. 1996 Jan;26(1):10-6
(Latest) J:197193 Jang S, et al., TSLP promotes induction of Th2 differentiation but is not necessary during established allergen-induced pulmonary disease. PLoS One. 2013;8(2):e56433
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory