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Tslp Gene Detail
Summary
  • Symbol
    Tslp
  • Name
    thymic stromal lymphopoietin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1855696
    NCBI Gene: 53603
  • Gene Overview
    MyGene.info: TSLP
Location & Maps
more
  • Sequence Map
    Chr18:32815383-32819799 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4417 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 18.12 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TSLP, thymic stromal lymphopoietin
  • Vertebrate Orthologs
    6
  • Human Ortholog
    TSLP, thymic stromal lymphopoietin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 85480
    neXtProt AC: NX_Q969D9

  • Chr Location
    5q22.1; chr5:111070080-111078024 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Tslp mouse models

Human Disease Mouse Models
       Anemia, Autoimmune Hemolytic   OMIM: 205700 View 1 model
Dermatitis, Atopic   OMIM: 603165 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 8 alleles in 9 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Targeted
    8
  • Transgenic
    3
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit resistance to MC903-induced atopic dermatitis. Mice homozygous for another knock-out allele exhibit altered airway inflammation induced by LPS.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 53603 NCBI Gene Model | MGI Sequence Detail 4417 C57BL/6J ±  kb
transcript NR_033206 RefSeq | MGI Sequence Detail 1146 C57BL/6  
polypeptide Q9JIE6 UniProt | EBI | MGI Sequence Detail 140 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    43 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 2
References
more
  • Summaries
    All 41
    Developmental Gene Expression 7
    Diseases 4
    Gene Ontology 2
    Phenotypes 29
  • Earliest
    J:33087 Ray RJ, et al., Characterization of thymic stromal-derived lymphopoietin (TSLP) in murine B cell development in vitro. Eur J Immunol. 1996 Jan;26(1):10-6
  • Latest
    J:233531 Cangkrama M, et al., Two Ancient Gene Families Are Critical for Maintenance of the Mammalian Skin Barrier in Postnatal Life. J Invest Dermatol. 2016 Jul;136(7):1438-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory