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Isg15
Gene Detail
 Symbol
Name
ID
Isg15
ISG15 ubiquitin-like modifier
MGI:1855694
Synonyms G1p2
Feature Type protein coding gene
Genetic Map
Chromosome 4
88.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:156199424-156200818 bp, - strand
From NCBI annotation of GRCm38

  1395 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48326  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Isg15

Human
homologs
Human Homolog ISG15, ISG15 ubiquitin-like modifier
NCBI Gene ID 9636
neXtProt AC  NX_P05161
Human Synonyms  G1P2, hUCRP, IFI15, IP17, UCRP
Human Chr (Location)  1p36.33; chr1:1013467-1014540 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile and do not display immunological abnormalities.
 
Interactions
Isg15 interacts with 26 markers (Mir32, Mir92-1, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process defense response to bacterium, defense response to virus, ...
Component cytoplasm, extracellular region
Function protein binding, protein tag
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (1)    Images (1)
Theiler Stages: 22
Assay TypeResults
Northern blot 3
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000035692 (Evidence)
Entrez Gene100038882 (Evidence)
DFCITC1581753
DoTSDT.99839683
NIA Mouse Gene IndexU363732, U368111
Consensus CDS ProjectCCDS51405.1
International Mouse Knockout Project StatusIsg15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 100038882 NCBI Gene Model | MGI Sequence Detail 1395 C57BL/6J ±  kb
transcript NM_015783 RefSeq | MGI Sequence Detail 756 C57BL/6 
polypeptide Q64339 UniProt | EBI | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000626 Ubiquitin
Protein Ontology PR:000029563 ubiquitin-like protein ISG15
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:207464 Basters A, et al., Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15. FEBS J. 2014 Apr;281(7):1918-28
All references(44)
Other
accession IDs
MGI:3809535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory