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Isg15
Gene Detail
Symbol

Name
ID
Isg15
ISG15 ubiquitin-like modifier
MGI:1855694
Synonyms
G1p2
Feature Type
protein coding gene
Genetic Map
Chromosome 4
88.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:156199424-156200818 bp, - strand
From NCBI annotation of GRCm38

  1395 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48326  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 2 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: ISG15
Gene Tree: Isg15

Human
homologs
ISG15, ISG15 ubiquitin-like modifier
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9636
neXtProt AC: NX_P05161

Human Synonyms: G1P2, hUCRP, IFI15, IMD38, IP17, UCRP

Human Chr (Location): 1p36.33; chr1:1013467-1014540 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ISG15

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable and fertile and do not display immunological abnormalities.
 
Interactions
Isg15 interacts with 26 markers (Mir32, Mir92-1, Mir92-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process defense response to bacterium, defense response to virus, ...
Component cytoplasm, extracellular region
Function protein binding, protein tag
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (3)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 3
cDNA source data(3)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000035692 (Evidence)
Entrez Gene 100038882 (Evidence)
DFCI TC1581753
DoTS DT.99839683
NIA Mouse Gene Index U368111, U363732
Consensus CDS Project CCDS51405.1
International Mouse Phenotyping Consortium Status Isg15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 100038882 NCBI Gene Model | MGI Sequence Detail 1395 C57BL/6J ±  kb
transcript NM_015783 RefSeq | MGI Sequence Detail 756 C57BL/6 
polypeptide Q64339 UniProt | EBI | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(23 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000626 Ubiquitin
Protein Ontology PR:000029563 ubiquitin-like protein ISG15
Graphical View of Protein Domain Structure
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218262 Sainz B Jr, et al., ISG15 is a critical microenvironmental factor for pancreatic cancer stem cells. Cancer Res. 2014 Dec 15;74(24):7309-20
All references(45)
Other
accession IDs
MGI:3809535

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory