Atoh7 MGI Mouse Gene Detail - MGI:1355553 - atonal bHLH transcription factor 7

Symbol

Atoh7
Name

atonal bHLH transcription factor 7
Synonyms

bHLHa13, Math5

Feature Type

protein coding gene
IDs

MGI:1355553
NCBI Gene: 53404
Alliance

genome feature page
Transcription Start Sites

1 TSS
Regulated by

Rr503, Rr502, Rr507 ... (4 regulatory regions)

Sequence Map

Chr10:62935564-62937059 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.54 cM
Mapping Data

3 experiments

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1355553	protein coding gene	Chr10:62935430-62937059 (+)
129S1/SvImJ	ENSMUSG00200027328	protein coding gene	Chr10:59608249-59609877 (+)
A/J	ENSMUSG00195026572	protein coding gene	Chr10:59915628-59917256 (+)
AKR/J	ENSMUSG00220036974	protein coding gene	Chr10:59608940-59610568 (+)
BALB/cJ	ENSMUSG00180026186	protein coding gene	Chr10:59957947-59959576 (+)
C3H/HeJ	ENSMUSG00175023397	protein coding gene	Chr10:59815413-59817041 (+)
C57BL/6NJ	ENSMUSG00215023274	protein coding gene	Chr10:59556020-59557648 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015398	protein coding gene	Chr10:57593439-57593888 (+)
CAST/EiJ	ENSTCUG00005027581	protein coding gene	Chr10:59608824-59610445 (+)
CBA/J	ENSMUSG00210033892	protein coding gene	Chr10:59693721-59695349 (+)
DBA/2J	ENSMUSG00185039679	protein coding gene	Chr10:60035315-60036943 (+)
FVB/NJ	ENSMUSG00205030174	protein coding gene	Chr10:59707414-59709041 (+)
JF1/MsJ	ENSUMUG00000018900	protein coding gene	Chr10:61280458-61282274 (+)
LP/J	ENSMUSG00230014511	protein coding gene	Chr10:61838172-61839800 (+)
NOD/ShiLtJ	ENSMUSG00190028539	protein coding gene	Chr10:60020945-60022573 (+)
NZO/HlLtJ	ENSMUSG00225043544	protein coding gene	Chr10:66119229-66120857 (+)
PWK/PhJ	ENSLUMG00010021741	protein coding gene	Chr10:59669398-59671213 (+)
SPRET/EiJ	ENSMSPG00010021520	protein coding gene	Chr10:61213278-61214911 (+)
WSB/EiJ	ENSIUOG00005040928	protein coding gene	Chr10:59601143-59602772 (+)

Human Ortholog

ATOH7, atonal bHLH transcription factor 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATOH7, atonal bHLH transcription factor 7
Synonyms

bHLHa13, Math5, NCRNA, PHPVAR, RNANC
Links

HGNC:13907

NCBI Gene ID: 220202

UniProt: Q8N100
Chr Location

10q21.3; chr10:68230595-68232113 (-) GRCh38

MGI Vertebrate Homology

Atoh7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATOH7
Gene Tree

Atoh7

Diseases

1 with human ATOH7 associations

				Human Disease	Mouse Models
				persistent hyperplastic primary vitreous IDs persistent hyperplastic primary vitreous DOID:0060282 MESH:D054514 NCI:C161554 OMIM:221900 OMIM:611308 ORDO:91495 UMLS_CUI:C0266568

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

39 phenotypes from 8 alleles in 12 genetic backgrounds
24 phenotypes from multigenic genotypes
87 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

11
Genomic Mutations

2 involving Atoh7
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutation of this gene results in impaired differentiation of retinal ganglion cells resulting in an increase of amacrine cells. Mice show impaired optic nerve formation and one allele shows loss of circadian photoentrainment.

less

All GO Annotations

42
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

882
Tissues

173
cDNA Data

11
Literature Summary

107

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ATOH7

Xenbase atoh7

ZFIN atoh7

less

All Sequences

33
RefSeq

4
UniProt

1
CCDS

CCDS23896.1

Ensembl

ENSMUSG00000036816 (Evidence)
NCBI Gene

53404

			Length	Strain/Species	Flank
genomic	53404	NCBI Gene Model \| MGI Sequence Detail	1496	C57BL/6J	± kb
transcript	NM_016864	RefSeq \| MGI Sequence Detail	1496	ZRU/MplStud
polypeptide	Q9Z2E5	UniProt \| EBI \| MGI Sequence Detail	149	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000004431 transcription factor ATOH7

(term hierarchy)
InterPro Domains

IPR050359 Basic helix-loop-helix transcription factors

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR032663 Transcription factor ATOH7, basic helix-loop-helix

less

All nucleic 23

Genomic 1

cDNA 14

Primer pair 6

Other 2

Antibodies 2

Microarray probesets 5

Summaries

All 199

Developmental Gene Expression 107

Gene Ontology 12

Phenotypes 87
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:386380 Krueger MR, et al., Roles of sonic hedgehog signaling in retinal patterning and neurogenesis during mammalian eye development. Development. 2026 May 1;153(9):dev205143

Atoh7 expression regulated by:

Feature	Feature Type	Location	Reference
Rr503, regulatory region 503	enhancer	Chr10:62923109-62927989	J:351037
Rr502, regulatory region 502	enhancer	Chr10:62932503-62934503	J:351037
Rr507, regulatory region 507	enhancer	Chr10:62933565-62935266	J:352431
Rr224923, regulatory region 224923	promoter	Chr10:62935400-62937001	J:352431

TSS for Atoh7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93748	Chr10:62935561-62935571 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24