Atoh7 MGI Mouse Gene Detail - MGI:1355553 - atonal bHLH transcription factor 7

Symbol

Atoh7
Name

atonal bHLH transcription factor 7
Synonyms

bHLHa13, Math5

Feature Type

protein coding gene
IDs

MGI:1355553
NCBI Gene: 53404
Alliance

gene page
Transcription Start Sites

1 TSS
Regulated by

Rr503, Rr502, Rr507 ... (4 regulatory regions)

Sequence Map

Chr10:62935564-62937059 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.54 cM
Mapping Data

3 experiments

SNPs within 2kb

173 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1355553	protein coding gene	Chr10:62935430-62937059 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017312	protein coding gene	Chr10:62606305-62606754 (+)
A/J	MGP_AJ_G0017290	protein coding gene	Chr10:60657360-60657809 (+)
AKR/J	MGP_AKRJ_G0017250	protein coding gene	Chr10:62262330-62262779 (+)
BALB/cJ	MGP_BALBcJ_G0017250	protein coding gene	Chr10:60770944-60771393 (+)
C3H/HeJ	MGP_C3HHeJ_G0017073	protein coding gene	Chr10:62167403-62167852 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017708	protein coding gene	Chr10:64849774-64850223 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015398	protein coding gene	Chr10:57593439-57593888 (+)
CAST/EiJ	MGP_CASTEiJ_G0016644	protein coding gene	Chr10:62227732-62228181 (+)
CBA/J	MGP_CBAJ_G0017045	protein coding gene	Chr10:67330449-67330898 (+)
DBA/2J	MGP_DBA2J_G0017150	protein coding gene	Chr10:59925445-59925894 (+)
FVB/NJ	MGP_FVBNJ_G0017144	protein coding gene	Chr10:59202758-59203207 (+)
LP/J	MGP_LPJ_G0017224	protein coding gene	Chr10:63010103-63010552 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017172	protein coding gene	Chr10:69466115-69466564 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017746	protein coding gene	Chr10:62099910-62100359 (+)
PWK/PhJ	MGP_PWKPhJ_G0016427	protein coding gene	Chr10:59813213-59813662 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016209	protein coding gene	Chr10:61446614-61447063 (+)
WSB/EiJ	MGP_WSBEiJ_G0016708	protein coding gene	Chr10:62054069-62054518 (+)

Human Ortholog

ATOH7, atonal bHLH transcription factor 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATOH7, atonal bHLH transcription factor 7
Synonyms

bHLHa13, Math5, NCRNA, PHPVAR, RNANC
Links

HGNC:13907

NCBI Gene ID: 220202

UniProt: Q8N100
Chr Location

10q21.3; chr10:68230595-68232113 (-) GRCh38

MGI Vertebrate Homology

Atoh7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATOH7
Gene Tree

Atoh7

Diseases

1 with human ATOH7 associations

				Human Disease	Mouse Models
				persistent hyperplastic primary vitreous IDs persistent hyperplastic primary vitreous DOID:0060282 MESH:D054514 NCI:C161554 OMIM:221900 OMIM:611308 ORDO:91495 UMLS_CUI:C0266568

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

39 phenotypes from 8 alleles in 12 genetic backgrounds
24 phenotypes from multigenic genotypes
84 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

11
Genomic Mutations

2 involving Atoh7
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutation of this gene results in impaired differentiation of retinal ganglion cells resulting in an increase of amacrine cells. Mice show impaired optic nerve formation and one allele shows loss of circadian photoentrainment.

less

All GO Annotations

46
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

979
Tissues

170
cDNA Data

11
Literature Summary

104

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ATOH7

Xenbase atoh7

ZFIN atoh7

less

All Sequences

32
RefSeq

4
UniProt

1
CCDS

CCDS23896.1

Ensembl

ENSMUSG00000036816 (Evidence)
NCBI Gene

53404

			Length	Strain/Species	Flank
genomic	53404	NCBI Gene Model \| MGI Sequence Detail	1496	C57BL/6J	± kb
transcript	NM_016864	RefSeq \| MGI Sequence Detail	1496	ZRU/MplStud
polypeptide	Q9Z2E5	UniProt \| EBI \| MGI Sequence Detail	149	Not Applicable

less

UniProt

1 Sequence
Protein Ontology

PR:000004431 transcription factor ATOH7

(term hierarchy)
InterPro Domains

IPR050359 Basic helix-loop-helix transcription factors

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR032663 Transcription factor ATOH7, basic helix-loop-helix

less

All nucleic 22

Genomic 1

cDNA 13

Primer pair 6

Other 2

Microarray probesets 5

Summaries

All 189

Developmental Gene Expression 104

Gene Ontology 13

Phenotypes 84
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:363242 Oliveira-Valenca VM, et al., POU4F2 overexpression promotes the genesis of retinal ganglion cell-like projection neurons from late progenitors. Development. 2025 Mar 1;152(5):DEV204297

Atoh7 expression regulated by:

Feature	Feature Type	Location	Reference
Rr503, regulatory region 503	enhancer	Chr10:62923109-62927989	J:351037
Rr502, regulatory region 502	enhancer	Chr10:62932503-62934503	J:351037
Rr507, regulatory region 507	enhancer	Chr10:62933565-62935266	J:352431
Rr224923, regulatory region 224923	promoter	Chr10:62935400-62937001	J:352431

TSS for Atoh7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93748	Chr10:62935561-62935571 (+)	2 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24