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Olig1
Gene Detail
Symbol

Name
ID
Olig1
oligodendrocyte transcription factor 1
MGI:1355334
Synonyms
Bhlhb6, bHLHe21, Olg-1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
52.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:91269772-91271933 bp, + strand
From VEGA annotation of GRCm38

  2162 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9667  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Olig1

Human
homologs
Human Homolog OLIG1, oligodendrocyte transcription factor 1
NCBI Gene ID 116448
neXtProt AC  NX_Q8TAK6
Human Synonyms  BHLHB6, BHLHE21
Human Chr (Location)  21q22.11; chr21:33070144-33072422 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Genomic Mutations involving Olig1 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in impaired maturation of oligodendrocytes.
 
Interactions
Olig1 interacts with 88 markers (Mir7-1, Mir10a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process multicellular organismal development, neuron fate commitment, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (57 records)
Data Summary: Results (294)    Tissues (161)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 263
Northern blot 12
RT-PCR 18
cDNA source data(22)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(23) Primer pair(3) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000019872 (Evidence)
Ensembl Gene ModelENSMUSG00000046160 (Evidence)
Entrez Gene50914 (Evidence)
UniGene39300
DFCITC1576760
DoTSDT.50315458
NIA Mouse Gene IndexU017368
Consensus CDS ProjectCCDS28324.1
International Mouse Knockout Project StatusOlig1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019872 VEGA Gene Model | MGI Sequence Detail 2162 C57BL/6J ±  kb
transcript OTTMUST00000047387 VEGA | MGI Sequence Detail 2162 Not Applicable 
polypeptide OTTMUSP00000021401 VEGA | MGI Sequence Detail 260 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000011631 oligodendrocyte transcription factor 1
References
(Earliest) J:60687 Zhou Q, et al., Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. Neuron. 2000 Feb;25(2):331-43
(Latest) J:212992 Silbereis JC, et al., Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 5;81(3):574-87
All references(116)
Other
accession IDs
MGI:2146489, MGI:2146642

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory