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Nckap1
Gene Detail
 Symbol
Name
ID
Nckap1
NCK-associated protein 1
MGI:1355333
Synonyms H19, Hem2, Hem-2, mh19, Nap1
Feature Type protein coding gene
Genetic Map
Chromosome 2
48.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:80500512-80581380 bp, - strand
From VEGA annotation of GRCm38

  80869 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8384  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: membrane-associated protein, HEM/NAP type
Gene Tree: Nckap1

Human
homologs
Human Homolog NCKAP1, NCK-associated protein 1
NCBI Gene ID 10787
neXtProt AC  NX_Q9Y2A7
Human Synonyms  HEM2, NAP1, NAP125, p125Nap1
Human Chr (Location)  2q32; chr2:182924851-183038858 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Chemically induced (ENU)(1) Gene trapped(16) Targeted(4)
Genomic Mutations involving Nckap1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit growth arrest at midgestation, an open neural tube, cardia bifida, defective foregut development, defects in endoderm and mesoderm migration and sometimes duplication of the anteroposterior body axis.
 
Interactions
Nckap1 interacts with 247 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process apical protein localization, basal protein localization, ...
Component cell projection, cytoplasm, ...
Function protein binding, protein complex binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (143)    Tissues (69)    Images (30)
Theiler Stages: 10, 18, 19, 22, 23, 25, 28
Assay TypeResults
RNA in situ 119
RT-PCR 24
cDNA source data(293)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(295) cDNA(293) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000013373 (Evidence)
Ensembl Gene ModelENSMUSG00000027002 (Evidence)
Entrez Gene50884 (Evidence)
UniGene25203
DFCITC1597260, TC1598006, TC1631853
DoTSDT.534717, DT.94150110
NIA Mouse Gene IndexU022797
Consensus CDS ProjectCCDS16177.1, CCDS71082.1
International Mouse Knockout Project StatusNckap1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013373 VEGA Gene Model | MGI Sequence Detail 80869 C57BL/6J ±  kb
transcript OTTMUST00000032325 VEGA | MGI Sequence Detail 4597 Not Applicable 
polypeptide OTTMUSP00000014352 VEGA | MGI Sequence Detail 1134 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(366 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019137 Nck-associated protein 1
Protein Ontology PR:000011035 Nck-associated protein 1
References (Earliest) J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
(Latest) J:207861 Manthey AL, et al., Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development. Mech Dev. 2014 Feb;131:86-110
All references(46)
Other
accession IDs
MGI:2139487

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory