Phgdh
Gene Detail

Symbol Name ID

Phgdh 3-phosphoglycerate dehydrogenase MGI:1355330

Synonyms

3PGDH, 3-PGDH, A10, PGAD, PGD, PGDH, SERA

Feature Type

protein coding gene

Genetic Map

Chromosome 3

42.74 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:98313170-98339990 bp, - strand From VEGA annotation of GRCm38   26821 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:39318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 3 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: D-3-phosphoglycerate dehydrogenase with ACT domain
Gene Tree: Phgdh

Human homologs

Human Homolog		PHGDH, phosphoglycerate dehydrogenase
NCBI Gene ID		26227
neXtProt AC		NX_O43175
Human Synonyms		3PGDH, 3-PGDH, PDG, PGAD, PGD, PGDH, SERA
Human Chr (Location)		1p12; chr1:120254419-120286849 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PHGDH

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a null allele die by E13.5 and exhibit abnormal neural development.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cellular amino acid biosynthetic process, G1 to G0 transition, ...
Function	cofactor binding, NAD binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (94)    Tissues (94)    Images (11)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000026317 (Evidence)
Ensembl Gene Model	ENSMUSG00000053398 (Evidence)
Entrez Gene	236539 (Evidence)
DFCI	TC1573835
DoTS	DT.101276394, DT.110999350
EC	1.1.1.95
Consensus CDS Project	CCDS17663.1
International Mouse Knockout Project Status	Phgdh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026317	VEGA Gene Model | MGI Sequence Detail	26821	C57BL/6J
transcript	OTTMUST00000065092	VEGA | MGI Sequence Detail	1893	Not Applicable
polypeptide	OTTMUSP00000032394	VEGA | MGI Sequence Detail	533	Not Applicable

All sequences(45) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(208 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006236	D-3-phosphoglycerate dehydrogenase
InterPro	IPR006139	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
InterPro	IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000012656	D-3-phosphoglycerate dehydrogenase

References

(Earliest) J:11875 Miller IJ, et al., A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol. 1993 May;13(5):2776-86
(Latest) J:184368 Mukhopadhyay P, et al., Strain-specific modifier genes governing craniofacial phenotypes. Birth Defects Res A Clin Mol Teratol. 2012 Mar;94(3):162-75
All references(38)