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Phgdh
Gene Detail
 Symbol
Name
ID
Phgdh
3-phosphoglycerate dehydrogenase
MGI:1355330
Synonyms 3PGDH, 3-PGDH, A10, PGAD, PGD, PGDH, SERA
Feature Type protein coding gene
Genetic Map
Chromosome 3
42.74 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:98313170-98339990 bp, - strand
From VEGA annotation of GRCm38

  26821 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 3 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: D-3-phosphoglycerate dehydrogenase with ACT domain
Gene Tree: Phgdh

Human
homologs
Human Homolog PHGDH, phosphoglycerate dehydrogenase
NCBI Gene ID 26227
neXtProt AC  NX_O43175
Human Synonyms  3PGDH, 3-PGDH, HEL-S-113, NLS, PDG, PGAD, PGD, PGDH, PHGDHD, SERA
Human Chr (Location)  1p12; chr1:119711796-119744226 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PHGDH
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele die by E13.5 and exhibit abnormal neural development.
 
Phenotype Images(2)
Interactions
Phgdh interacts with 16 markers (Mir27a, Mir27b, Mir331, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular amino acid biosynthetic process, G1 to G0 transition, ...
Component extracellular vesicular exosome
Function NAD binding, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (94)    Tissues (94)    Images (11)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000026317 (Evidence)
Ensembl Gene ModelENSMUSG00000053398 (Evidence)
Entrez Gene236539 (Evidence)
DFCITC1573835
DoTSDT.101276394, DT.110999350
EC1.1.1.95
Consensus CDS ProjectCCDS17663.1
International Mouse Knockout Project StatusPhgdh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026317 VEGA Gene Model | MGI Sequence Detail 26821 C57BL/6J ±  kb
transcript OTTMUST00000065092 VEGA | MGI Sequence Detail 1893 Not Applicable 
polypeptide OTTMUSP00000032394 VEGA | MGI Sequence Detail 533 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(284 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006236 D-3-phosphoglycerate dehydrogenase
InterPro IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
InterPro IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000012656 D-3-phosphoglycerate dehydrogenase
References (Earliest) J:11875 Miller IJ, et al., A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol Cell Biol. 1993 May;13(5):2776-86
(Latest) J:199792 Ehmsen JT, et al., D-Serine in Glia and Neurons Derives from 3-Phosphoglycerate Dehydrogenase. J Neurosci. 2013 Jul 24;33(30):12464-12469
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory