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Symbol Name ID |
Phgdh
3-phosphoglycerate dehydrogenase MGI:1355330 |
| Darker colors indicate more annotations |
| Human Phenotypes | Reduced 3-phosphoglycerate dehydrogenase activity |
Generalized edema |
| Disease(s) Associated with PHGDH | ||
| Neu-Laxova syndrome 1 | ||
| PHGDH deficiency |
| Mouse Phenotypes | decreased arginine level |
increased arginine level |
increased circulating glycine level |
decreased cystathionine level |
decreased glutamic acid level |
increased glutamine level |
decreased glycine level |
decreased phenylalanine level |
increased phenylalanine level |
decreased serine level |
decreased threonine level |
edema |
decreased respiratory quotient |
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| Availability | Mouse Genotype | |||||||||||||
| Phgdhtm1b(KOMP)Wtsi/Phgdhtm1b(KOMP)Wtsi | ||||||||||||||
| Phgdhtm1b(KOMP)Wtsi/Phgdh+ | ||||||||||||||
| Phgdhtm1.2Shfu/Phgdhtm1.2Shfu Tg(GFAP-cre)25Mes/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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