Slc7a8
Gene Detail

Symbol Name ID

Slc7a8 solute carrier family 7 (cationic amino acid transporter, y+ system), member 8 MGI:1355323

Synonyms

LAT2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

27.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:54722216-54781886 bp, - strand From Ensembl annotation of GRCm38   59671 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc7a8 ± 2 cM)

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a8

Human ortholog

SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 NCBI Gene ID 23428
Human Synonyms: LAT2, LPI-PC1
Human Chr14:23594504-23652849 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a targeted mutation display hypoactivity, decreased motor performance, and resistance to pharmacologically induced seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	amino acid transmembrane transport, amino acid transport, ...
Component	cytoplasm, integral to membrane, ...
Function	amine transmembrane transporter activity, amino acid transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (200)    Tissues (171)    Images (8)
Theiler Stages: 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	101
In situ reporter (knock in)	54
RT-PCR	45

cDNA source data(48)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) cDNA(48) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022180 (Evidence)
Entrez Gene	50934 (Evidence)
UniGene	276831
DFCI	TC1575842, TC1594216
DoTS	DT.530443, DT.91582805
NIA Mouse Gene Index	U035560
Consensus CDS Project	CCDS27101.1
International Mouse Knockout Project Status	Slc7a8

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022180	Ensembl Gene Model | MGI Sequence Detail	59671	C57BL/6J
transcript	ENSMUST00000022787	Ensembl | MGI Sequence Detail	4033	Not Applicable
polypeptide	ENSMUSP00000022787	Ensembl | MGI Sequence Detail	531	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(409 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002293	Amino acid/polyamine transporter I
InterPro	IPR004760	L-type amino acid transporter
Protein Ontology	PR:000015205	large neutral amino acids transporter small subunit 2

References

(Earliest) J:59975 Bassi MT, et al., SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family. Genomics. 1999 Dec 1;62(2):297-303
(Latest) J:176748 Braun D, et al., Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8. Biochem J. 2011 Oct 15;439(2):249-55
All references(33)

Other accession IDs

MGI:2145551