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Slc7a8 Gene Detail
Summary
  • Symbol
    Slc7a8
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
  • Synonyms
    LAT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355323
    NCBI Gene: 50934
  • Gene Overview
    MyGene.info: SLC7A8
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:54722215-54781886 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59672 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 27.91 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SLC7A8, solute carrier family 7 member 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC7A8, solute carrier family 7 member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAT2, LPI-PC1
  • Links
    NCBI Gene ID: 23428
    neXtProt AC: NX_Q9UHI5
    UniProt: Q9UHI5

  • Chr Location
    14q11.2; chr14:23125295-23183660 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display hypoactivity, decreased motor performance, and resistance to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 50934 NCBI Gene Model | MGI Sequence Detail 59672 C57BL/6J ±  kb
transcript NM_016972 RefSeq | MGI Sequence Detail 4064 C57BL/6  
polypeptide Q9QXW9 UniProt | EBI | MGI Sequence Detail 531 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    747 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 55
    Genomic 1
    cDNA 50
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145551
References
more
  • Summaries
    All 42
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:59975 Bassi MT, et al., SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family. Genomics. 1999 Dec 1;62(2):297-303
  • Latest
    J:256844 Espino Guarch M, et al., Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss. Elife. 2018 Jan 22;7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory