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Slc7a8 Gene Detail
Summary
  • Symbol
    Slc7a8
  • Name
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
  • Synonyms
    LAT2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355323
    NCBI Gene: 50934
Location & Maps
more
  • Sequence Map
    Chr14:54722216-54781886 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59671 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC7A8, solute carrier family 7 (amino acid transporter light chain, L system), member 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC7A8, solute carrier family 7 (amino acid transporter light chain, L system), member 8
    Orthology source: HomoloGene
  • Synonyms
    LAT2, LPI-PC1
  • Links
    NCBI Gene ID: 23428
    neXtProt AC: NX_Q9UHI5

  • Chr Location
    14q11.2; chr14:23125295-23183660 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Slc7a8
  • Incidental Mutations
Mice homozygous for a targeted mutation display hypoactivity, decreased motor performance, and resistance to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022180 Ensembl Gene Model | MGI Sequence Detail 59671 C57BL/6J ±  kb
transcript ENSMUST00000022787 Ensembl | MGI Sequence Detail 4033 Not Applicable  
polypeptide ENSMUSP00000022787 Ensembl | MGI Sequence Detail 531 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    760 from dbSNP Build 137
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR002293 Amino acid/polyamine transporter I
    IPR004760 L-type amino acid transporter
Molecular
Reagents
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  • All nucleic 53
    cDNA 50
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145551
References
more
  • Summaries
    All 32
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:59975 Bassi MT, et al., SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family. Genomics. 1999 Dec 1;62(2):297-303
  • Latest
    J:216253 Nunez B, et al., Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation. PLoS One. 2014;9(5):e96915

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory