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Slc7a8
Gene Detail
Symbol

Name
ID
Slc7a8
solute carrier family 7 (cationic amino acid transporter, y+ system), member 8
MGI:1355323
Synonyms
LAT2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
27.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:54722216-54781886 bp, - strand
From Ensembl annotation of GRCm38

  59671 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:8166  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: amino acid transporter
Gene Tree: Slc7a8

Human
homologs
Human Homolog SLC7A8, solute carrier family 7 (amino acid transporter light chain, L system), member 8
NCBI Gene ID 23428
neXtProt AC  NX_Q9UHI5
Human Synonyms  LAT2, LPI-PC1
Human Chr (Location)  14q11.2; chr14:23125295-23183660 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display hypoactivity, decreased motor performance, and resistance to pharmacologically induced seizures.
 
Interactions
Slc7a8 interacts with 256 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (200)    Tissues (171)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 101
In situ reporter (knock in) 54
RT-PCR 45
cDNA source data(50)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(52) cDNA(50) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022180 (Evidence)
Entrez Gene50934 (Evidence)
UniGene276831
DFCITC1575842, TC1594216
DoTSDT.530443, DT.91582805
NIA Mouse Gene IndexU035560
Consensus CDS ProjectCCDS27101.1
International Mouse Knockout Project StatusSlc7a8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022180 Ensembl Gene Model | MGI Sequence Detail 59671 C57BL/6J ±  kb
transcript ENSMUST00000022787 Ensembl | MGI Sequence Detail 4033 Not Applicable 
polypeptide ENSMUSP00000022787 Ensembl | MGI Sequence Detail 531 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(760 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002293 Amino acid/polyamine transporter I
InterPro IPR004760 L-type amino acid transporter
Protein Ontology PR:000015205 large neutral amino acids transporter small subunit 2
References
(Earliest) J:59975 Bassi MT, et al., SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family. Genomics. 1999 Dec 1;62(2):297-303
(Latest) J:201184 Ferrara AM, et al., Changes in thyroid status during perinatal development of MCT8-deficient male mice. Endocrinology. 2013 Jul;154(7):2533-41
All references(34)
Other
accession IDs
MGI:2145551

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory