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Chek2 Gene Detail
Summary
  • Symbol
    Chek2
  • Name
    checkpoint kinase 2
  • Synonyms
    CHK2, Rad53
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355321
    NCBI Gene: 50883
  • Gene Overview
    MyGene.info: CHEK2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:110839979-110874145 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.73 cM, cytoband F
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355321
protein coding gene Chr5:110839800-110874145 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029895
protein coding gene Chr5:113322227-113354313 (+)
A/J MGP_AJ_G0029861
protein coding gene Chr5:108930840-108968504 (+)
AKR/J MGP_AKRJ_G0029799
protein coding gene Chr5:112389573-112426255 (+)
BALB/cJ MGP_BALBcJ_G0029872
protein coding gene Chr5:110303316-110338985 (+)
C3H/HeJ MGP_C3HHeJ_G0029592
protein coding gene Chr5:112831893-112869861 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030325
protein coding gene Chr5:117775789-117813575 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027554
protein coding gene Chr5:103765401-103800398 (+)
CAST/EiJ MGP_CASTEiJ_G0029000
protein coding gene Chr5:111693823-111728962 (+)
CBA/J MGP_CBAJ_G0029559
protein coding gene Chr5:122205720-122243106 (+)
DBA/2J MGP_DBA2J_G0029709
protein coding gene Chr5:109008241-109043203 (+)
FVB/NJ MGP_FVBNJ_G0029666
protein coding gene Chr5:107679577-107715116 (+)
LP/J MGP_LPJ_G0029797
protein coding gene Chr5:113874543-113905294 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029697
protein coding gene Chr5:126848595-126883148 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030366
protein coding gene Chr5:111832970-111863066 (+)
PWK/PhJ MGP_PWKPhJ_G0028714
protein coding gene Chr5:107590605-107626658 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028552
protein coding gene Chr5:109300019-109344372 (+)
WSB/EiJ MGP_WSBEiJ_G0029076
protein coding gene Chr5:112310480-112347394 (+)



Homology
more
  • Human Ortholog
    CHEK2, checkpoint kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHEK2, checkpoint kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDS1, CHK2, hCds1, HuCds1, LFS2, PP1425, RAD53
  • Links
    NCBI Gene ID: 11200
    neXtProt AC: NX_O96017
    UniProt: O96017

  • Chr Location
    22q12.1; chr22:28687743-28741866 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38289
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHEK2
  • Gene Tree
Human Diseases
more
  • Diseases
    4 with human CHEK2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 5 genetic backgrounds
    13 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene does not increase tumor incidence. Cells from the thymus, central nervous system (CNS), hair follicles, and skin are resistant to ionizing radiation- and gamma irradiation-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029521 Ensembl Gene Model | MGI Sequence Detail 34167 C57BL/6J ±  kb
    transcript ENSMUST00000066160 Ensembl | MGI Sequence Detail 2276 Not Applicable  
    polypeptide ENSMUSP00000066679 Ensembl | MGI Sequence Detail 546 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 28
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 19
      Gene Ontology 11
      Phenotypes 48
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:263685 Kitami K, et al., BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLoS Genet. 2018 May;14(5):e1007340

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory