About   Help   FAQ
Chek2
Gene Detail
 Symbol
Name
ID
Chek2
checkpoint kinase 2
MGI:1355321
Synonyms CHK2, Rad53
Feature Type protein coding gene
Genetic Map
Chromosome 5
53.73 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:110840017-110874133 bp, + strand
From NCBI annotation of GRCm38

  34117 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Chek2

Human
homologs
Human Homolog CHEK2, checkpoint kinase 2
NCBI Gene ID 11200
neXtProt AC  NX_O96017
Human Synonyms  CDS1, CHK2, hCds1, HuCds1, LFS2, PP1425, RAD53
Human Chr (Location)  22q12.1; chr22:28687743-28741834 (-)  GRCh38
Disease Associations  (5) Diseases Associated with Human CHEK2
Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(21) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene does not increase tumor incidence. Cells from the thymus, central nervous system (CNS), hair follicles, and skin are resistant to ionizing radiation- and gamma irradiation-induced apoptosis.
 
Interactions
Chek2 interacts with 128 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process apoptotic process, cell cycle, ...
Component chromosome, telomeric region, intracellular, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (65)    Tissues (21)    Images (23)
Theiler Stages: 17, 18, 20, 23, 26, 28
Assay TypeResults
RNA in situ 61
RT-PCR 4
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029521 (Evidence)
Entrez Gene50883 (Evidence)
UniGene279308
DFCITC1580592
DoTSDT.101269582, DT.101293471, DT.110690644
NIA Mouse Gene IndexU005982
EC2.7.11.1
Consensus CDS ProjectCCDS19533.1
International Mouse Knockout Project StatusChek2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 50883 NCBI Gene Model | MGI Sequence Detail 34117 C57BL/6J ±  kb
transcript NM_016681 RefSeq | MGI Sequence Detail 2247 C57BL/6 
polypeptide Q9Z265 UniProt | EBI | MGI Sequence Detail 546 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(16) UniProt(2)
Polymorphisms SNPs within 2kb(339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000005418 serine/threonine-protein kinase Chk2
Graphical View of Protein Domain Structure
References (Earliest) J:61425 Matsuoka S, et al., Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7
(Latest) J:209346 Dai XX, et al., Chk2 regulates cell cycle progression during mouse oocyte maturation and early embryo development. Mol Cells. 2014 Feb;37(2):126-32
All references(72)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory