About   Help   FAQ
Chek2
Gene Detail
Symbol

Name
ID
Chek2
checkpoint kinase 2
MGI:1355321
Synonyms
CHK2, Rad53
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.73 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:110840017-110874133 bp, + strand
From Ensembl annotation of GRCm38

  34117 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHEK2
Gene Tree: Chek2

Human
homologs
CHEK2, checkpoint kinase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 11200
neXtProt AC: NX_O96017

Human Synonyms: CDS1, CHK2, hCds1, HuCds1, LFS2, PP1425, RAD53

Human Chr (Location): 22q12.1; chr22:28687743-28741905 (-)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human CHEK2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(21) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene does not increase tumor incidence. Cells from the thymus, central nervous system (CNS), hair follicles, and skin are resistant to ionizing radiation- and gamma irradiation-induced apoptosis.
 
Interactions
Chek2 interacts with 128 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process apoptotic process, cell cycle, ...
Component chromosome, telomeric region, Golgi apparatus, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (65)    Tissues (21)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 61
RT-PCR 4
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase chek2 ; ZFIN chek2    NEW 
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000029521 (Evidence)
Entrez Gene 50883 (Evidence)
UniGene 279308
DFCI TC1580592
DoTS DT.101293471, DT.110690644, DT.101269582
NIA Mouse Gene Index U005982
EC 2.7.11.1
Consensus CDS Project CCDS19533.1
International Mouse Phenotyping Consortium Status Chek2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029521 Ensembl Gene Model | MGI Sequence Detail 34117 C57BL/6J ±  kb
transcript ENSMUST00000066160 Ensembl | MGI Sequence Detail 2247 Not Applicable 
polypeptide ENSMUSP00000066679 Ensembl | MGI Sequence Detail 546 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(17) UniProt(2)
Polymorphisms
SNPs within 2kb(339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000005418 serine/threonine-protein kinase Chk2
References
(Earliest) J:61425 Matsuoka S, et al., Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7
(Latest) J:217323 Garcia-Beccaria M, et al., In vivo role of checkpoint kinase 2 in signaling telomere dysfunction. Aging Cell. 2014 Oct;13(5):810-6
All references(75)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory