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Chek2
Gene Detail
Symbol

Name
ID
Chek2
checkpoint kinase 2
MGI:1355321
Synonyms
CHK2, Rad53
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.73 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:110839979-110874145 bp, + strand
From VEGA annotation of GRCm38

  34167 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHEK2
Gene Tree: Chek2

Human
homologs
CHEK2, checkpoint kinase 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11200
neXtProt AC: NX_O96017

Human Synonyms: CDS1, CHK2, hCds1, HuCds1, LFS2, PP1425, RAD53

Human Chr (Location): 22q12.1; chr22:28687743-28741905 (-)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human CHEK2

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Gene trapped(21) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene does not increase tumor incidence. Cells from the thymus, central nervous system (CNS), hair follicles, and skin are resistant to ionizing radiation- and gamma irradiation-induced apoptosis.
 
Interactions
Chek2 interacts with 128 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process apoptotic process, cell cycle, ...
Component chromosome, telomeric region, Golgi apparatus, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (65)    Tissues (21)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 61
RT-PCR 4
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase chek2 ; ZFIN chek2    NEW 
Molecular
reagents
All nucleic(28) cDNA(27) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000054224 (Evidence)
Ensembl Gene Model ENSMUSG00000029521 (Evidence)
Entrez Gene 50883 (Evidence)
UniGene 279308
DFCI TC1580592
DoTS DT.101269582, DT.101293471, DT.110690644
NIA Mouse Gene Index U005982
EC 2.7.11.1
Consensus CDS Project CCDS19533.1
International Mouse Phenotyping Consortium Status Chek2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054224 VEGA Gene Model | MGI Sequence Detail 34167 C57BL/6J ±  kb
transcript OTTMUST00000134619 VEGA | MGI Sequence Detail 2276 Not Applicable 
polypeptide OTTMUSP00000071369 VEGA | MGI Sequence Detail 546 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(17) UniProt(5)
Polymorphisms
SNPs within 2kb(339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000005418 serine/threonine-protein kinase Chk2
References
(Earliest) J:61425 Matsuoka S, et al., Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7
(Latest) J:217323 Garcia-Beccaria M, et al., In vivo role of checkpoint kinase 2 in signaling telomere dysfunction. Aging Cell. 2014 Oct;13(5):810-6
All references(78)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory