Chek2
Gene Detail

Symbol Name ID

Chek2 checkpoint kinase 2 MGI:1355321

Synonyms

CHK2, Rad53

Feature Type

protein coding gene

Genetic Map

Chromosome 5

53.73 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr5:110840017-110874133 bp, + strand From NCBI annotation of GRCm38   34117 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38289  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chek2

Human homologs

Human Homolog		CHEK2, checkpoint kinase 2
NCBI Gene ID		11200
neXtProt AC		NX_O96017
Human Synonyms		CDS1, CHK2, hCds1, HuCds1, LFS2, PP1425, RAD53
Human Chr (Location)		22q12.1; chr22:29083731-29137822 (-)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human CHEK2

Alleles and phenotypes

All alleles(26) : Targeted(5) Gene trapped(21)
 

Homozygous mutation of this gene does not increase tumor incidence. Cells from the thymus, central nervous system (CNS), hair follicles, and skin are resistant to ionizing radiation- and gamma irradiation-induced apoptosis.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	apoptotic process, cell cycle, ...
Component	chromosome, telomeric region, nucleus, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (65)    Tissues (21)    Images (23)
Theiler Stages: 17, 18, 20, 23, 26, 28

Assay Type	Results
RNA in situ	61
RT-PCR	4

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) cDNA(28) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000029521 (Evidence)
Entrez Gene	50883 (Evidence)
UniGene	279308
DFCI	TC1580592
DoTS	DT.101269582, DT.101293471, DT.110690644
NIA Mouse Gene Index	U005982
EC	2.7.11.1
Consensus CDS Project	CCDS19533.1
International Mouse Knockout Project Status	Chek2

Sequences

Length	Strain/Species
genomic	50883	NCBI Gene Model | MGI Sequence Detail	34117	C57BL/6J
transcript	NM_016681	RefSeq | MGI Sequence Detail	2247	C57BL/6
polypeptide	Q9Z265	UniProt | EBI | MGI Sequence Detail	546	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(198 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR008984	SMAD/FHA domain
Protein Ontology	PR:000005418	serine/threonine-protein kinase Chk2

Graphical View of Protein Domain Structure

References

(Earliest) J:61425 Matsuoka S, et al., Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7
(Latest) J:191367 Lee Y, et al., Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Nat Neurosci. 2012 Jun;15(6):819-26
All references(67)