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Chek2 Gene Detail
Summary
  • Symbol
    Chek2
  • Name
    checkpoint kinase 2
  • Synonyms
    CHK2, Rad53
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355321
    NCBI Gene: 50883
  • Gene Overview
    MyGene.info: CHEK2
Location & Maps
more
  • Sequence Map
    Chr5:110839979-110874145 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34167 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.73 cM, cytoband F
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CHEK2, checkpoint kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHEK2, checkpoint kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDS1, CHK2, hCds1, HuCds1, LFS2, PP1425, RAD53
  • Links
    NCBI Gene ID: 11200
    neXtProt AC: NX_O96017

  • Chr Location
    22q12.1; chr22:28687743-28741905 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 38289
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHEK2
  • Gene Tree
Human Diseases
more
  • Diseases
    5 with human CHEK2 associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480
Checkpoint Kinase 2, S. Pombe, Homolog Of; CHEK2   OMIM: 604373
Li-Fraumeni Syndrome 2; LFS2   OMIM: 609265
Osteogenic Sarcoma   OMIM: 259500
Prostate Cancer   OMIM: 176807
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 5 genetic backgrounds
    12 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Chek2
  • Incidental Mutations
Homozygous mutation of this gene does not increase tumor incidence. Cells from the thymus, central nervous system (CNS), hair follicles, and skin are resistant to ionizing radiation- and gamma irradiation-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054224 VEGA Gene Model | MGI Sequence Detail 34167 C57BL/6J ±  kb
transcript OTTMUST00000134619 VEGA | MGI Sequence Detail 2276 Not Applicable  
polypeptide OTTMUSP00000071369 VEGA | MGI Sequence Detail 546 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    331 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 29
    cDNA 27
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 84
    Developmental Gene Expression 13
    Gene Ontology 10
    Phenotypes 44
  • Earliest
    J:61425 Matsuoka S, et al., Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science. 1998 Dec 4;282(5395):1893-7
  • Latest
    J:233087 Dong D, et al., Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress. Biochem Biophys Res Commun. 2015 Nov 13;467(2):407-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory