Ddb2
Gene Detail

Symbol Name ID

Ddb2 damage specific DNA binding protein 2 MGI:1355314

Synonyms

2610043A19Rik, p48

Feature Type

protein coding gene

Genetic Map

Chromosome 2

50.56 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:91211572-91236982 bp, - strand From VEGA annotation of GRCm38   25411 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:83  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ddb2

Human homologs

Human Homolog		DDB2, damage-specific DNA binding protein 2, 48kDa
NCBI Gene ID		1643
neXtProt AC		NX_Q92466
Human Synonyms		DDBB, UV-DDB2
Human Chr (Location)		11p12-p11; chr11:47236493-47260769 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DDB2

Alleles and phenotypes

All alleles(12) : Targeted(5) Gene trapped(7)
 

Mutant mice are prone to both spontaneous and UV-induced skin cancer.

 
Human Diseases Modeled Using Mouse Ddb2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	DNA repair, protein autoubiquitination, ...
Component	nucleus, protein complex
Function	DNA binding, ubiquitin-protein ligase activity

External Resources: FuncBase

Expression

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(41) cDNA(41)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000014414 (Evidence)
Ensembl Gene Model	ENSMUSG00000002109 (Evidence)
Entrez Gene	107986 (Evidence)
UniGene	389334
Consensus CDS Project	CCDS16428.1
International Mouse Knockout Project Status	Ddb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014414	VEGA Gene Model | MGI Sequence Detail	25411	C57BL/6J
transcript	OTTMUST00000034162	VEGA | MGI Sequence Detail	1557	Not Applicable
polypeptide	OTTMUSP00000015309	VEGA | MGI Sequence Detail	432	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000006341	DNA damage-binding protein 2

References

(Earliest) J:61007 Zolezzi F, et al., Studies of the murine DDB1 and DDB2 genes. Gene. 2000 Mar 7;245(1):151-9
(Latest) J:185041 Luijsterburg MS, et al., DDB2 promotes chromatin decondensation at UV-induced DNA damage. J Cell Biol. 2012 Apr 16;197(2):267-81
All references(41)

Other accession IDs

MGI:1919388