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Ddb2
Gene Detail
 Symbol
Name
ID
Ddb2
damage specific DNA binding protein 2
MGI:1355314
Synonyms 2610043A19Rik, p48
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.56 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:91211572-91236982 bp, - strand
From VEGA annotation of GRCm38

  25411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:83  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ddb2

Human
homologs
Human Homolog DDB2, damage-specific DNA binding protein 2, 48kDa
NCBI Gene ID 1643
neXtProt AC  NX_Q92466
Human Synonyms  DDBB, UV-DDB2
Human Chr (Location)  11p12-p11; chr11:47214465-47239218 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DDB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(7) Targeted(9)
Genomic Mutations involving Ddb2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice are prone to both spontaneous and UV-induced skin cancer.
 
Human Diseases Modeled Using Mouse Ddb2 (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Ddb2 interacts with 54 markers (Mir1b, Mir22, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component Cul4B-RING E3 ubiquitin ligase complex, nucleus, ...
Function damaged DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(39)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(39) cDNA(39)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000014414 (Evidence)
Ensembl Gene ModelENSMUSG00000002109 (Evidence)
Entrez Gene107986 (Evidence)
UniGene389334
Consensus CDS ProjectCCDS16428.1
International Mouse Knockout Project StatusDdb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014414 VEGA Gene Model | MGI Sequence Detail 25411 C57BL/6J ±  kb
transcript OTTMUST00000034162 VEGA | MGI Sequence Detail 1557 Not Applicable 
polypeptide OTTMUSP00000015309 VEGA | MGI Sequence Detail 432 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000006341 DNA damage-binding protein 2
References (Earliest) J:61007 Zolezzi F, et al., Studies of the murine DDB1 and DDB2 genes. Gene. 2000 Mar 7;245(1):151-9
(Latest) J:185041 Luijsterburg MS, et al., DDB2 promotes chromatin decondensation at UV-induced DNA damage. J Cell Biol. 2012 Apr 16;197(2):267-81
All references(42)
Disease annotation references (2)
Other
accession IDs
MGI:1919388

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory