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Ddb2 Gene Detail
Summary
  • Symbol
    Ddb2
  • Name
    damage specific DNA binding protein 2
  • Synonyms
    2610043A19Rik, p48
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355314
    NCBI Gene: 107986
  • Gene Overview
    MyGene.info: DDB2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:91211572-91236982 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.56 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1355314
protein coding gene Chr2:91211545-91237132 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026146
protein coding gene Chr2:92522530-92554352 (-)
A/J MGP_AJ_G0026107
protein coding gene Chr2:88822470-88849031 (-)
AKR/J MGP_AKRJ_G0026088
protein coding gene Chr2:91277455-91302852 (-)
BALB/cJ MGP_BALBcJ_G0026116
protein coding gene Chr2:89002153-89030226 (-)
C3H/HeJ MGP_C3HHeJ_G0025867
protein coding gene Chr2:91555332-91583898 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026567
protein coding gene Chr2:95787326-95815415 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023957
protein coding gene Chr2:85332379-85355877 (-)
CAST/EiJ MGP_CASTEiJ_G0025332
protein coding gene Chr2:92083813-92113350 (-)
CBA/J MGP_CBAJ_G0025845
protein coding gene Chr2:99033922-99070733 (-)
DBA/2J MGP_DBA2J_G0025981
protein coding gene Chr2:88423073-88448583 (-)
FVB/NJ MGP_FVBNJ_G0025944
protein coding gene Chr2:87532947-87557990 (-)
LP/J MGP_LPJ_G0026085
protein coding gene Chr2:92736330-92766007 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025970
protein coding gene Chr2:102075092-102104071 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026621
protein coding gene Chr2:91347754-91375544 (-)
PWK/PhJ MGP_PWKPhJ_G0025067
protein coding gene Chr2:88151753-88178391 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024868
protein coding gene Chr2:90917292-90942867 (-)
WSB/EiJ MGP_WSBEiJ_G0025399
protein coding gene Chr2:91945001-91974744 (-)



Homology
more
  • Human Ortholog
    DDB2, damage specific DNA binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDB2, damage specific DNA binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DDBB, UV-DDB2, XPE
  • Links
    NCBI Gene ID: 1643
    neXtProt AC: NX_Q92466
    UniProt: Q92466

  • Chr Location
    11p11.2; chr11:47214942-47239218 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 83
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DDB2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ddb2 mouse models; 1 with human DDB2 associations

Human Disease Mouse Models
      
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice are prone to both spontaneous and UV-induced skin cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002109 Ensembl Gene Model | MGI Sequence Detail 25411 C57BL/6J ±  kb
transcript ENSMUST00000028696 Ensembl | MGI Sequence Detail 1557 Not Applicable  
polypeptide ENSMUSP00000028696 Ensembl | MGI Sequence Detail 432 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 40

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919388
References
more
  • Summaries
    All 51
    Diseases 2
    Gene Ontology 6
    Phenotypes 19
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:227263 Fabre PJ, et al., Nanoscale spatial organization of the HoxD gene cluster in distinct transcriptional states. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13964-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory