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Ddb2 Gene Detail
Summary
  • Symbol
    Ddb2
  • Name
    damage specific DNA binding protein 2
  • Synonyms
    2610043A19Rik, p48
  • Feature Type
    protein coding gene
  • IDs
    MGI:1355314
    NCBI Gene: 107986
  • Gene Overview
    MyGene.info: DDB2
Location & Maps
more
  • Sequence Map
    Chr2:91211572-91236982 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25411 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 50.56 cM, cytoband E1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DDB2, damage specific DNA binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DDB2, damage specific DNA binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DDBB, UV-DDB2, XPE
  • Links
    NCBI Gene ID: 1643
    neXtProt AC: NX_Q92466

  • Chr Location
    11p11.2; chr11:47214942-47239218 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 83
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: DDB2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ddb2 mouse models; 1 with human DDB2 associations

Human Disease Mouse Models
       Xeroderma Pigmentosum, Complementation Group E   OMIM: 278740 View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    4 involving Ddb2
  • Incidental Mutations
Mutant mice are prone to both spontaneous and UV-induced skin cancer.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014414 VEGA Gene Model | MGI Sequence Detail 25411 C57BL/6J ±  kb
transcript OTTMUST00000034162 VEGA | MGI Sequence Detail 1557 Not Applicable  
polypeptide OTTMUSP00000015309 VEGA | MGI Sequence Detail 432 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    66 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 39

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919388
References
more
  • Summaries
    All 42
    Diseases 2
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:61007 Zolezzi F, et al., Studies of the murine DDB1 and DDB2 genes. Gene. 2000 Mar 7;245(1):151-9
  • Latest
    J:185041 Luijsterburg MS, et al., DDB2 promotes chromatin decondensation at UV-induced DNA damage. J Cell Biol. 2012 Apr 16;197(2):267-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory