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Dlc1 Gene Detail
Summary
  • Symbol
    Dlc1
  • Name
    deleted in liver cancer 1
  • Synonyms
    A730069N07Rik, Arhgap7, p122-RhoGAP, STARD12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354949
    NCBI Gene: 50768
Location & Maps
more
  • Sequence Map
    Chr8:36567751-36953143 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      385393 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DLC1, DLC1 Rho GTPase activating protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DLC1, DLC1 Rho GTPase activating protein
    Orthology source: HomoloGene
  • Synonyms
    ARHGAP7, HP, p122-RhoGAP, STARD12
  • Links
    NCBI Gene ID: 10395
    neXtProt AC: NX_Q96QB1

  • Chr Location
    8p22; chr8:13083361-13515658 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4442
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DLC1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DLC1 associations

Human Disease Mouse Models
       Colorectal Cancer; CRC   OMIM: 114500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 2 genetic backgrounds
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta. Mouse embryonic fibroblasts homozygous for an activated conditional allele exhibti increased sensitivity to Ras-induced transformation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028535 VEGA Gene Model | MGI Sequence Detail 385393 C57BL/6J ±  kb
transcript OTTMUST00000092190 VEGA | MGI Sequence Detail 5113 Not Applicable  
polypeptide OTTMUSP00000050896 VEGA | MGI Sequence Detail 1543 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4551 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 21
    Genomic 1
    cDNA 19
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2442088
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:60865 Yuan BZ, et al., Assignment and cloning of mouse Arhgap7 to chromosome 8A4-B2, a conserved syntenic region of human chromosome 8p22-->p21. Cytogenet Cell Genet. 1999;87(3-4):189-90
  • Latest
    J:209624 Wang Y, et al., DLC1-dependent parathyroid hormone-like hormone inhibition suppresses breast cancer bone metastasis. J Clin Invest. 2014 Apr 1;124(4):1646-59

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory