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Gene Detail
deleted in liver cancer 1
Synonyms A730069N07Rik, Arhgap7, p122-RhoGAP, STARD12
Feature Type protein coding gene
Genetic Map
Chromosome 8
23.05 cM, cytoband A4-B2
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr8:36567751-36953143 bp, - strand
From VEGA annotation of GRCm38

  385393 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:4442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dlc1

Human Homolog DLC1, DLC1 Rho GTPase activating protein
NCBI Gene ID 10395
neXtProt AC  NX_Q96QB1
Human Synonyms  ARHGAP7, HP, p122-RhoGAP, STARD12
Human Chr (Location)  8p22; chr8:13083361-13515658 (-)  GRCh38
alleles, and
All mutations/alleles(281) : Gene trapped(275) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta. Mouse embryonic fibroblasts homozygous for an activated conditional allele exhibti increased sensitivity to Ras-induced transformation.
Phenotype Images(2)
Dlc1 interacts with 399 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
All GO classifications: (40 annotations)
Process actin cytoskeleton organization, activation of cysteine-type endopeptidase activity involved in apoptotic process, ...
Component actin filament, caveola, ...
Function GTPase activator activity, lipid binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (4 records)
Data Summary: Results (54)    Tissues (16)    Images (17)
Theiler Stages: 16, 23, 28
Assay TypeResults
RNA in situ 46
Northern blot 8
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(20) Genomic(1) cDNA(18) Primer pair(1)
Microarray probesets(6)
Other database
VEGA Gene ModelOTTMUSG00000028535 (Evidence)
Ensembl Gene ModelENSMUSG00000031523 (Evidence)
Entrez Gene50768 (Evidence)
DFCITC1584474, TC1590331, TC1592852, TC1595387, TC1605183, TC1605951, TC1657710
DoTSDT.101306346, DT.101338950, DT.101358847, DT.101725097, DT.40137456, DT.91302625, DT.91416115, DT.91420810, DT.91565087
NIA Mouse Gene IndexU029734, U029743
Consensus CDS ProjectCCDS40322.1, CCDS57616.1, CCDS57617.1
International Mouse Knockout Project StatusDlc1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028535 VEGA Gene Model | MGI Sequence Detail 385393 C57BL/6J ±  kb
transcript OTTMUST00000092190 VEGA | MGI Sequence Detail 5113 Not Applicable 
polypeptide OTTMUSP00000050896 VEGA | MGI Sequence Detail 1543 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(15) UniProt(12)
Polymorphisms SNPs within 2kb(4551 from dbSNP Build 137)
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR002913 START domain
InterPro IPR023393 START-like domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
Protein Ontology PR:000006505 rho GTPase-activating protein 7
References (Earliest) J:60865 Yuan BZ, et al., Assignment and cloning of mouse Arhgap7 to chromosome 8A4-B2, a conserved syntenic region of human chromosome 8p22-->p21. Cytogenet Cell Genet. 1999;87(3-4):189-90
(Latest) J:192878 Qian X, et al., Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer. Cancer Res. 2012 Nov 15;72(22):5900-11
All references(46)
accession IDs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory