Polg2
Gene Detail

Symbol Name ID

Polg2 polymerase (DNA directed), gamma 2, accessory subunit MGI:1354947

Feature Type

protein coding gene

Genetic Map

Chromosome 11

70.01 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:106768253-106779537 bp, - strand From VEGA annotation of GRCm38   11285 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Polg2

Human homologs

Human Homolog		POLG2, polymerase (DNA directed), gamma 2, accessory subunit
NCBI Gene ID		11232
neXtProt AC		NX_Q9UHN1
Human Synonyms		HP55, MTPOLB, PEOA4, POLB, POLGB, POLG-BETA
Human Chr (Location)		17q; chr17:62473902-62493184 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human POLG2

Alleles and phenotypes

All alleles(14) : Targeted(5) Gene trapped(9)
 

Mice homozygous for a knock-out allele exhibit embryonic lethality between somite formation and turning, fail to initiate turning, lack mt-Co1 activity, and contain abnormal mitochondria with reduced mtDNA.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	DNA repair, DNA replication, ...
Component	mitochondrial nucleoid, mitochondrion
Function	DNA binding, DNA-directed DNA polymerase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (9)    Tissues (9)    Images (1)
Theiler Stages: 2, 3, 4, 5, 28

Assay Type	Results
RT-PCR	9

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000003591 (Evidence)
Ensembl Gene Model	ENSMUSG00000020718 (Evidence)
Entrez Gene	50776 (Evidence)
UniGene	859
DFCI	TC1600601
DoTS	DT.101356525, DT.527203, DT.94132438
NIA Mouse Gene Index	U033548
EC	2.7.7.7
PDB	1G5H, 1G5I
Consensus CDS Project	CCDS25561.1
International Mouse Knockout Project Status	Polg2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003591	VEGA Gene Model | MGI Sequence Detail	11285	C57BL/6J
transcript	OTTMUST00000007741	VEGA | MGI Sequence Detail	1506	Not Applicable
polypeptide	OTTMUSP00000003758	VEGA | MGI Sequence Detail	459	Not Applicable

All sequences(49) RefSeq(3) UniProt(6)

Polymorphisms

SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004154	Anticodon-binding
InterPro	IPR027030	DNA polymerase subunit gamma-2, mitochondrial
InterPro	IPR027031	Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2
Protein Ontology	PR:000012974	DNA polymerase subunit gamma-2, mitochondrial

References

(Earliest) J:60695 Carrodeguas JA, et al., Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase. Nucleic Acids Res. 2000 Mar 1;28(5):1237-44
(Latest) J:192568 Humble MM, et al., Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance. Hum Mol Genet. 2013 Mar 1;22(5):1017-25
All references(35)