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Polg2
Gene Detail
Symbol

Name
ID
Polg2
polymerase (DNA directed), gamma 2, accessory subunit
MGI:1354947
Feature Type
protein coding gene
Genetic Map
Chromosome 11
70.01 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:106768253-106779537 bp, - strand
From VEGA annotation of GRCm38

  11285 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5221  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: POLG2
Gene Tree: Polg2

Human
homologs
POLG2, polymerase (DNA directed), gamma 2, accessory subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11232
neXtProt AC: NX_Q9UHN1

Human Synonyms: HP55, MTPOLB, PEOA4, POLB, POLGB, POLG-BETA

Human Chr (Location): 17q; chr17:64476994-64497066 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human POLG2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit embryonic lethality between somite formation and turning, fail to initiate turning, lack mt-Co1 activity, and contain abnormal mitochondria with reduced mtDNA.
 
Interactions
Polg2 interacts with 257 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process DNA biosynthetic process, DNA repair, ...
Component extracellular exosome, mitochondrial chromosome, ...
Function DNA binding, DNA-directed DNA polymerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (5)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 5
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100493143 ; ZFIN polg2    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000003591 (Evidence)
Ensembl Gene Model ENSMUSG00000020718 (Evidence)
Entrez Gene 50776 (Evidence)
UniGene 859
DFCI TC1600601
DoTS DT.101356525, DT.94132438, DT.527203
NIA Mouse Gene Index U033548
EC 2.7.7.7
PDB 1G5I, 1G5H
Consensus CDS Project CCDS25561.1
International Mouse Phenotyping Consortium Status Polg2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003591 VEGA Gene Model | MGI Sequence Detail 11285 C57BL/6J ±  kb
transcript OTTMUST00000007741 VEGA | MGI Sequence Detail 1506 Not Applicable 
polypeptide OTTMUSP00000003758 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(6)
Polymorphisms
SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004154 Anticodon-binding
InterPro IPR027030 DNA polymerase subunit gamma-2, mitochondrial
InterPro IPR027031 Glycyl-tRNA synthetase/DNA polymerase subunit gamma-2
Protein Ontology PR:000012974 DNA polymerase subunit gamma-2, mitochondrial
References
(Earliest) J:60695 Carrodeguas JA, et al., Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase. Nucleic Acids Res. 2000 Mar 1;28(5):1237-44
(Latest) J:192568 Humble MM, et al., Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance. Hum Mol Genet. 2013 Mar 1;22(5):1017-25
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory