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Orc3 Gene Detail
Summary
  • Symbol
    Orc3
  • Name
    origin recognition complex, subunit 3
  • Synonyms
    Orc3l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354944
    NCBI Gene: 50793
  • Gene Overview
    MyGene.info: ORC3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:34570796-34614944 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 16.81 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    283 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354944
protein coding gene Chr4:34566781-34614944 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028127
protein coding gene Chr4:32154750-32200249 (-)
A/J MGP_AJ_G0028085
protein coding gene Chr4:30971660-31031611 (-)
AKR/J MGP_AKRJ_G0028048
protein coding gene Chr4:31795935-31842508 (-)
BALB/cJ MGP_BALBcJ_G0028096
protein coding gene Chr4:31261306-31308845 (-)
C3H/HeJ MGP_C3HHeJ_G0027825
protein coding gene Chr4:32112934-32158941 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028538
protein coding gene Chr4:33379769-33429263 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025879
protein coding gene Chr4:29097684-29145379 (-)
CAST/EiJ MGP_CASTEiJ_G0027280
protein coding gene Chr4:31904279-31951154 (-)
CBA/J MGP_CBAJ_G0027797
protein coding gene Chr4:34453413-34517853 (-)
DBA/2J MGP_DBA2J_G0027941
protein coding gene Chr4:30966972-31011348 (-)
FVB/NJ MGP_FVBNJ_G0027907
protein coding gene Chr4:30382463-30426934 (-)
LP/J MGP_LPJ_G0028049
protein coding gene Chr4:32240270-32289932 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027940
protein coding gene Chr4:37060571-37109427 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028597
protein coding gene Chr4:31823981-31870008 (-)
PWK/PhJ MGP_PWKPhJ_G0026999
protein coding gene Chr4:30975970-31023246 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026828
protein coding gene Chr4:31683026-31726675 (-)
WSB/EiJ MGP_WSBEiJ_G0027356
protein coding gene Chr4:31824051-31867518 (-)



Homology
more
  • Human Ortholog
    ORC3, origin recognition complex subunit 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ORC3, origin recognition complex subunit 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LAT, LATHEO, ORC3L
  • Links
    NCBI Gene ID: 23595
    neXtProt AC: NX_Q9UBD5
    UniProt: Q9UBD5

  • Chr Location
    6q15; chr6:87590067-87677824 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8225
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ORC3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in the neural cells exhibit reduced neuronal precursor proliferation and reduced radial glial cell.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040044 Ensembl Gene Model | MGI Sequence Detail 44149 C57BL/6J ±  kb
transcript ENSMUST00000048706 Ensembl | MGI Sequence Detail 2300 Not Applicable  
polypeptide ENSMUSP00000048319 Ensembl | MGI Sequence Detail 715 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 1
    cDNA 16

    Microarray probesets 7
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:60868 Springer J, et al., Identification and chromosomal localization of murine ORC3, a new member of the mouse origin recognition complex. Cytogenet Cell Genet. 1999;87(3-4):245-51
  • Latest
    J:194480 Ma S, et al., Radial glial neural progenitors regulate nascent brain vascular network stabilization via inhibition of Wnt signaling. PLoS Biol. 2013 Jan;11(1):e1001469

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory