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Fbxw5 Gene Detail
Summary
  • Symbol
    Fbxw5
  • Name
    F-box and WD-40 domain protein 5
  • Synonyms
    Fbw5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354731
    NCBI Gene: 30839
  • Gene Overview
    MyGene.info: FBXW5
Location & Maps
more
  • Sequence Map
    Chr2:25500750-25505471 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      4722 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.31 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FBXW5, F-box and WD repeat domain containing 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FBXW5, F-box and WD repeat domain containing 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Fbw5
  • Links
    NCBI Gene ID: 54461
    neXtProt AC: NX_Q969U6

  • Chr Location
    9q34.3; chr9:136940433-136944774 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    4
  • Targeted
    1
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    13
  • Tissues
    7
  • cDNA Data
    81
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012119 VEGA Gene Model | MGI Sequence Detail 4722 C57BL/6J ±  kb
transcript OTTMUST00000028918 VEGA | MGI Sequence Detail 2388 Not Applicable  
polypeptide OTTMUSP00000013070 VEGA | MGI Sequence Detail 573 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    67 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007426 F-box/WD repeat-containing protein 5
  • InterPro Domains
    IPR001810 F-box domain
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
less
  • All nucleic 82
    cDNA 82

    Microarray probesets 5
Other
Accession IDs
less
MGI:2138847
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:195223 Werner A, et al., SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression. Nat Cell Biol. 2013 Feb;15(2):179-88
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory