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Fbxw5 Gene Detail
Summary
  • Symbol
    Fbxw5
  • Name
    F-box and WD-40 domain protein 5
  • Synonyms
    Fbw5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354731
    NCBI Gene: 30839
  • Gene Overview
    MyGene.info: FBXW5
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:25500767-25505471 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 17.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354731
 protein coding gene Chr2:25500750-25505471 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025452
 protein coding gene Chr2:23392216-23396944 (+)
A/J MGP_AJ_G0025429
 protein coding gene Chr2:22486483-22491229 (+)
AKR/J MGP_AKRJ_G0025399
 protein coding gene Chr2:23235360-23245049 (+)
BALB/cJ MGP_BALBcJ_G0025425
 protein coding gene Chr2:22598799-22603851 (+)
C3H/HeJ MGP_C3HHeJ_G0025186
 protein coding gene Chr2:23183625-23188843 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025869
 protein coding gene Chr2:24139193-24143914 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023280
 protein coding gene Chr2:21398338-21403045 (+)
CAST/EiJ MGP_CASTEiJ_G0024649
 protein coding gene Chr2:23051789-23056559 (+)
CBA/J MGP_CBAJ_G0025164
 protein coding gene Chr2:24969380-24978041 (+)
DBA/2J MGP_DBA2J_G0025297
 protein coding gene Chr2:22324211-22329446 (+)
FVB/NJ MGP_FVBNJ_G0025259
 protein coding gene Chr2:22069641-22074346 (+)
LP/J MGP_LPJ_G0025383
 protein coding gene Chr2:23332459-23337651 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025290
 protein coding gene Chr2:25165786-25170914 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025928
 protein coding gene Chr2:23189343-23194051 (+)
PWK/PhJ MGP_PWKPhJ_G0024397
 protein coding gene Chr2:22146690-22151469 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024197
 protein coding gene Chr2:23330179-23334870 (+)
WSB/EiJ MGP_WSBEiJ_G0024718
 protein coding gene Chr2:23264699-23269425 (+)



Homology
more
  • Human Ortholog
    FBXW5, F-box and WD repeat domain containing 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    FBXW5, F-box and WD repeat domain containing 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Fbw5
  • Links
    NCBI Gene ID: 54461
    neXtProt AC: NX_Q969U6
    UniProt: Q969U6

  • Chr Location
    9q34.3; chr9:136940433-136944774 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    13
  • Tissues
    7
  • cDNA Data
    82
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 30839 NCBI Gene Model | MGI Sequence Detail 4705 C57BL/6J ±  kb
transcript NM_001356408 RefSeq | MGI Sequence Detail 2401 C57BL/6  
polypeptide Q9QXW2 UniProt | EBI | MGI Sequence Detail 573 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 83
    cDNA 83

    Microarray probesets 5
Other
Accession IDs
less
MGI:2138847
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
  • Latest
    J:242956 Delprato A, et al., Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Genes Brain Behav. 2015 Nov;14(8):591-606
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/08/2019
MGI 6.14 		The Jackson Laboratory