Fbxw5 MGI Mouse Gene Detail - MGI:1354731 - F-box and WD-40 domain protein 5

Symbol

Fbxw5
Name

F-box and WD-40 domain protein 5
Synonyms

Fbw5

Feature Type

protein coding gene
IDs

MGI:1354731
NCBI Gene: 30839
Gene Overview

MyGene.info: FBXW5
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:25500750-25505470 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.31 cM
Mapping Data

3 experiments

SNPs within 2kb

67 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1354731	protein coding gene	Chr2:25500750-25505471 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025452	protein coding gene	Chr2:23392216-23396944 (+)
A/J	MGP_AJ_G0025429	protein coding gene	Chr2:22486483-22491229 (+)
AKR/J	MGP_AKRJ_G0025399	protein coding gene	Chr2:23235360-23245049 (+)
BALB/cJ	MGP_BALBcJ_G0025425	protein coding gene	Chr2:22598799-22603851 (+)
C3H/HeJ	MGP_C3HHeJ_G0025186	protein coding gene	Chr2:23183625-23188843 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025869	protein coding gene	Chr2:24139193-24143914 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023280	protein coding gene	Chr2:21398338-21403045 (+)
CAST/EiJ	MGP_CASTEiJ_G0024649	protein coding gene	Chr2:23051789-23056559 (+)
CBA/J	MGP_CBAJ_G0025164	protein coding gene	Chr2:24969380-24978041 (+)
DBA/2J	MGP_DBA2J_G0025297	protein coding gene	Chr2:22324211-22329446 (+)
FVB/NJ	MGP_FVBNJ_G0025259	protein coding gene	Chr2:22069641-22074346 (+)
LP/J	MGP_LPJ_G0025383	protein coding gene	Chr2:23332459-23337651 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025290	protein coding gene	Chr2:25165786-25170914 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025928	protein coding gene	Chr2:23189343-23194051 (+)
PWK/PhJ	MGP_PWKPhJ_G0024397	protein coding gene	Chr2:22146690-22151469 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024197	protein coding gene	Chr2:23330179-23334870 (+)
WSB/EiJ	MGP_WSBEiJ_G0024718	protein coding gene	Chr2:23264699-23269425 (+)

Human Ortholog

FBXW5, F-box and WD repeat domain containing 5

Vertebrate Orthologs

8

Human Ortholog

FBXW5, F-box and WD repeat domain containing 5
Orthology source: HomoloGene, HGNC
Synonyms

Fbw5
Links

HGNC:13613

NCBI Gene ID: 54461

neXtProt AC: NX_Q969U6

UniProt: Q969U6
Chr Location

9q34.3; chr9:136940433-136944774 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8496
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish
HCOP

human homology predictions: FBXW5
Gene Tree

Fbxw5

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

4
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

3 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased susceptibility to myocardial ischemic injury.

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All GO Annotations

15
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

644
Tissues

7
cDNA Data

82
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxw5

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Fbxw5 interacts with 82 markers (Mir18, Mir22, Mir23b, ...) View All

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All Sequences

59
RefSeq

6
UniProt

2
CCDS

CCDS15778.1
UniGene

29170

Ensembl

ENSMUSG00000015095 (Evidence)
NCBI Gene

30839

			Length	Strain/Species	Flank
genomic	30839	NCBI Gene Model \| MGI Sequence Detail	4721	C57BL/6J	± kb
transcript	NM_001356408	RefSeq \| MGI Sequence Detail	2401	C57BL/6
polypeptide	Q9QXW2	UniProt \| EBI \| MGI Sequence Detail	573	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007426 F-box/WD repeat-containing protein 5

(term hierarchy)
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR042508 F-box/WD repeat-containing protein 5

IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily

IPR001680 WD40 repeat

IPR017986 WD40-repeat-containing domain

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 83

cDNA 83

Microarray probesets 5

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MGI:2138847

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 5
Earliest

J:58149 Winston JT, et al., A family of mammalian F-box proteins. Curr Biol. 1999 Oct 21;9(20):1180-2
Latest

J:298305 Hui X, et al., FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway. J Mol Cell Cardiol. 2020 Sep 22;151:31-43

TSS for Fbxw5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16733	Chr2:25500764-25500769 (+)	17 bp
Tssr16734	Chr2:25500772-25500783 (+)	28 bp
Tssr16735	Chr2:25500789-25500864 (+)	77 bp
Tssr16736	Chr2:25501819-25501841 (+)	1,080 bp
Tssr16737	Chr2:25501843-25501850 (+)	1,097 bp
Tssr16738	Chr2:25501860-25501874 (+)	1,117 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16