About   Help   FAQ
Atp8a2
Gene Detail
 Symbol
Name
ID
Atp8a2
ATPase, aminophospholipid transporter-like, class I, type 8A, member 2
MGI:1354710
Synonyms Ib, wl
Feature Type protein coding gene
Genetic Map
Chromosome 14
31.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr14:59647531-60197179 bp, - strand
From VEGA annotation of GRCm38

  549649 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Atp8a2

Human
homologs
Human Homolog ATP8A2, ATPase, aminophospholipid transporter, class I, type 8A, member 2
NCBI Gene ID 51761
neXtProt AC  NX_Q9NTI2
Human Synonyms  ATP, ATPIB, CAMRQ4, IB, ML-1
Human Chr (Location)  13q12; chr13:25372071-26025851 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ATP8A2
Alleles
and
phenotypes
All alleles(6) : Gene trapped(2) Spontaneous(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygotes for spontaneous mutations have abnormal gait and tremors, with axonal degeneration in central and peripheral neurons. Symptoms progress to immobility and death by 1-month of age. Heterozygotes show subtle locomotor abnormalities and are hyporesponsive to tail pinching.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process aging, ATP catabolic process, ...
Component cell projection, endosome, ...
Function ATP binding, cation-transporting ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (173)    Tissues (55)    Images (23)
Theiler Stages: 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 165
Northern blot 8
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(16) cDNA(16)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000032689 (Evidence)
Ensembl Gene ModelENSMUSG00000021983 (Evidence)
Entrez Gene50769 (Evidence)
UniGene319599
DFCITC1588380, TC1611132, TC1631392, TC1663588
DoTSDT.101704175, DT.110771063, DT.481263, DT.55211018
NIA Mouse Gene IndexU035640
EC3.6.3.1
Consensus CDS ProjectCCDS27174.1
International Mouse Knockout Project StatusAtp8a2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032689 VEGA Gene Model | MGI Sequence Detail 549649 C57BL/6J ±  kb
transcript OTTMUST00000081340 VEGA | MGI Sequence Detail 3895 Not Applicable 
polypeptide OTTMUSP00000043499 VEGA | MGI Sequence Detail 1148 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(12) UniProt(6)
Polymorphisms SNPs within 2kb(3274 from dbSNP Build 137)    SNPs within 2kb including multiple locations(3312)
Protein-related
information
ResourceIDDescription
InterPro IPR001757 Cation-transporting P-type ATPase
InterPro IPR023214 HAD-like domain
InterPro IPR006539 Phospholipid-transporting P-type ATPase, subfamily IV
InterPro IPR008250 P-type ATPase, A domain
InterPro IPR023299 P-type ATPase, cytoplasmic domain N
InterPro IPR018303 P-type ATPase, phosphorylation site
Protein Ontology PR:000029291 phospholipid-transporting ATPase IB
References (Earliest) J:13068 Dickie MM, et al., A juvenile wabbler-lethal in the house mouse. J Hered. 1952;43:283-286
(Latest) J:188127 Zhu X, et al., Mutations in a P-type ATPase gene cause axonal degeneration. PLoS Genet. 2012 Aug;8(8):e1002853
All references(51)
Other
accession IDs
MGD-MRK-15403, MGD-MRK-15435, MGI:2145631, MGI:98951

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory