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Ero1l Gene Detail
Summary
  • Symbol
    Ero1l
  • Name
    ERO1-like (S. cerevisiae)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354385
    NCBI Gene: 50527
  • Gene Overview
    MyGene.info: ERO1A
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:45283087-45318572 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.86 cM, cytoband C-D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354385
protein coding gene Chr14:45283087-45318771 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021206
protein coding gene Chr14:38901183-38939913 (-)
A/J MGP_AJ_G0021152
protein coding gene Chr14:37746417-37783430 (-)
AKR/J MGP_AKRJ_G0021130
protein coding gene Chr14:39228690-39266998 (-)
BALB/cJ MGP_BALBcJ_G0021156
protein coding gene Chr14:37798807-37833780 (-)
C3H/HeJ MGP_C3HHeJ_G0020939
protein coding gene Chr14:39036536-39074524 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021590
protein coding gene Chr14:40598465-40634175 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019149
protein coding gene Chr14:37171010-37211556 (-)
CAST/EiJ MGP_CASTEiJ_G0020464
protein coding gene Chr14:36148693-36191686 (-)
CBA/J MGP_CBAJ_G0020905
protein coding gene Chr14:41881160-41928418 (-)
DBA/2J MGP_DBA2J_G0021028
protein coding gene Chr14:37668869-37705934 (-)
FVB/NJ MGP_FVBNJ_G0021012
protein coding gene Chr14:37428046-37463361 (-)
LP/J MGP_LPJ_G0021098
protein coding gene Chr14:39186704-39227444 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021038
protein coding gene Chr14:41290180-41329431 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021623
protein coding gene Chr14:38767028-38804294 (-)
PWK/PhJ MGP_PWKPhJ_G0020213
protein coding gene Chr14:34530481-34566669 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020035
protein coding gene Chr14:34921583-34960609 (-)
WSB/EiJ MGP_WSBEiJ_G0020520
protein coding gene Chr14:38874235-38915440 (-)



Homology
more
  • Human Ortholog
    ERO1A, endoplasmic reticulum oxidoreductase 1 alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ERO1A, endoplasmic reticulum oxidoreductase 1 alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Ero1alpha, ERO1-alpha, ERO1L, ERO1-L, ERO1LA, ERO1-L-alpha
  • Links
    NCBI Gene ID: 30001
    neXtProt AC: NX_Q96HE7
    UniProt: Q96HE7

  • Chr Location
    14q22.1; chr14:52639915-52695931 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit decreased apoptosis and calcium release in macrophages exposed to endoplasmic reticulum stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 50527 NCBI Gene Model | MGI Sequence Detail 35486 C57BL/6J ±  kb
transcript NM_015774 RefSeq | MGI Sequence Detail 4435 C57BL/6  
polypeptide Q8R180 UniProt | EBI | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 197
    cDNA 197

    Microarray probesets 6
References
more
  • Summaries
    All 50
    Developmental Gene Expression 5
    Gene Ontology 14
    Phenotypes 14
  • Earliest
    J:60564 Cabibbo A, et al., ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J Biol Chem. 2000 Feb 18;275(7):4827-33
  • Latest
    J:246486 Kajiwara T, et al., Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-alpha-mediated oxidative folding in murine tumor cells. Eur J Immunol. 2016 Dec;46(12):2842-2851

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory