Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables protein-disulfide reductase activity. Involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including brown fat cell differentiation; cell redox homeostasis; and protein maturation by protein folding. Predicted to be located in several cellular components, including Golgi lumen; dendrite; and endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adipose tissue; bone; liver; lung; and spleen. Orthologous to human ERO1A (endoplasmic reticulum oxidoreductase 1 alpha).