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E2f6 Gene Detail
Summary
  • Symbol
    E2f6
  • Name
    E2F transcription factor 6
  • Synonyms
    EMA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354159
    NCBI Gene: 50496
Location & Maps
more
  • Sequence Map
    Chr12:16810965-16826743 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15779 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    E2F6, E2F transcription factor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    E2F6, E2F transcription factor 6
    Orthology source: HomoloGene
  • Synonyms
    E2F-6
  • Links
    NCBI Gene ID: 1876
    neXtProt AC: NX_O75461

  • Chr Location
    2p25.1; chr2:11444375-11466177 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 2 genetic backgrounds
    18 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Both homozygous and heterozygous null mice exhibit subtle posterior transformations of the axial skeleton with incomplete penetrance. In addition to skeletal transformations, male mice homozygous for one knock-out allele display defective spermatocyte development and Leydig cell hyperplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057469 Ensembl Gene Model | MGI Sequence Detail 15779 C57BL/6J ±  kb
transcript ENSMUST00000020908 Ensembl | MGI Sequence Detail 2421 Not Applicable  
polypeptide ENSMUSP00000020908 Ensembl | MGI Sequence Detail 272 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    164 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000006857 transcription factor E2F6
  • InterPro Domains
    IPR003316 E2F/DP family, winged-helix DNA-binding domain
    IPR015633 E2F Family
    IPR032198 E2F transcription factor, CC-MB domain
    IPR015635 Transcription factor E2F6
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 69
    cDNA 65
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2144836
References
more
  • Summaries
    All 46
    Developmental Gene Expression 14
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:44763 Morkel M, et al., An E2F-like repressor of transcription [letter]. Nature. 1997 Dec 11;390(6660):567-8
  • Latest
    J:228946 Wei N, et al., SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Rep. 2015 Nov 24;13(8):1647-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory