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Glrx3 Gene Detail
Summary
  • Symbol
    Glrx3
  • Name
    glutaredoxin 3
  • Synonyms
    PICOT, PKC interacting cousin of thioredoxin, Txnl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353653
    NCBI Gene: 30926
  • Gene Overview
    MyGene.info: GLRX3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:137437614-137468594 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30981 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 82.32 cM, cytoband F5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GLRX3, glutaredoxin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GLRX3, glutaredoxin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3
  • Links
    NCBI Gene ID: 10539
    neXtProt AC: NX_O76003
    UniProt: O76003

  • Chr Location
    10q26.3; chr10:130136375-130182877 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4769
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: GLRX3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit lethality during late organogenesis and early fetal development. Mice heterozygous for this gene trapped allele exhibit increased response to cardiac injury and decreased cardiac muscle contractility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000060317 VEGA Gene Model | MGI Sequence Detail 30981 C57BL/6J ±  kb
    transcript OTTMUST00000147611 VEGA | MGI Sequence Detail 3440 Not Applicable  
    polypeptide OTTMUSP00000076816 VEGA | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      135 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 5
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:60175 Witte S, et al., Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. J Biol Chem. 2000 Jan 21;275(3):1902-9
    • Latest
      J:250979 Kim J, et al., PICOT alleviates myocardial ischemia-reperfusion injury by reducing intracellular levels of reactive oxygen species. Biochem Biophys Res Commun. 2017 Apr 15;485(4):807-813

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory