Fus
Gene Detail

Symbol Name ID

Fus fused in sarcoma MGI:1353633

Synonyms

D430004D17Rik, D930039C12Rik, hnRNP P2, pigpen, Tls, translocated in liposarcoma

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:127967457-127982368 bp, + strand From VEGA annotation of GRCm38   14912 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: RNA-binding protein, EWS type
Gene Tree: Fus

Human homologs

Human Homolog		FUS, fused in sarcoma
NCBI Gene ID		2521
neXtProt AC		NX_P35637
Human Synonyms		ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS
Human Chr (Location)		16p11.2; chr16:31191431-31206192 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FUS

Alleles and phenotypes

All alleles(24) : Targeted(4) Gene trapped(20)
 

Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Component	cytoplasm, nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (223)    Tissues (199)    Images (13)
Theiler Stages: 10, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	207
Northern blot	4
Western blot	10
RT-PCR	2

cDNA source data(169)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(171) cDNA(170) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016476 (Evidence)
Ensembl Gene Model	ENSMUSG00000030795 (Evidence)
Entrez Gene	233908 (Evidence)
UniGene	277680
NIA Mouse Gene Index	U008824, U065479
Consensus CDS Project	CCDS21886.1
International Mouse Knockout Project Status	Fus

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016476	VEGA Gene Model | MGI Sequence Detail	14912	C57BL/6J
transcript	OTTMUST00000039732	VEGA | MGI Sequence Detail	2203	Not Applicable
polypeptide	OTTMUSP00000017730	VEGA | MGI Sequence Detail	518	Not Applicable

All sequences(72) RefSeq(2) UniProt(8)

Polymorphisms

SNPs(68 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR001876	Zinc finger, RanBP2-type
Protein Ontology	PR:000007700	RNA-binding protein FUS

References

(Earliest) J:54190 Mencinger M, et al., Characterization of TFG in mus musculus and Caenorhabditis elegans. Biochem Biophys Res Commun. 1999 Apr 2;257(1):67-73
(Latest) J:192741 Lagier-Tourenne C, et al., Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nat Neurosci. 2012 Nov;15(11):1488-97
All references(51)

Other accession IDs

MGI:2443475, MGI:2445182