About   Help   FAQ
Fus Gene Detail
Summary
  • Symbol
    Fus
  • Name
    fused in sarcoma
  • Synonyms
    D430004D17Rik, D930039C12Rik, hnRNP P2, pigpen, Tls, translocated in liposarcoma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353633
    NCBI Gene: 233908
  • Gene Overview
    MyGene.info: FUS
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127966788-127982032 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353633
protein coding gene Chr7:127966788-127985701 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033067
protein coding gene Chr7:132362303-132381815 (+)
A/J MGP_AJ_G0033050
protein coding gene Chr7:128813723-128831663 (+)
AKR/J MGP_AKRJ_G0032982
protein coding gene Chr7:132153319-132174658 (+)
BALB/cJ MGP_BALBcJ_G0033051
protein coding gene Chr7:128472987-128491045 (+)
C3H/HeJ MGP_C3HHeJ_G0032765
protein coding gene Chr7:132053460-132072208 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033560
protein coding gene Chr7:137512033-137531041 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030533
protein coding gene Chr7:130005701-130023157 (+)
CAST/EiJ MGP_CASTEiJ_G0032094
protein coding gene Chr7:123845997-123865225 (+)
CBA/J MGP_CBAJ_G0032738
protein coding gene Chr7:142185720-142206584 (+)
DBA/2J MGP_DBA2J_G0032890
protein coding gene Chr7:126791022-126810688 (+)
FVB/NJ MGP_FVBNJ_G0032843
protein coding gene Chr7:126652620-126671411 (+)
LP/J MGP_LPJ_G0032984
protein coding gene Chr7:133824185-133842754 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032875
protein coding gene Chr7:143260448-143279589 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033580
protein coding gene Chr7:131136126-131157871 (+)
PWK/PhJ MGP_PWKPhJ_G0031801
protein coding gene Chr7:119798376-119817092 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031647
protein coding gene Chr7:117945551-117963677 (+)
WSB/EiJ MGP_WSBEiJ_G0032206
protein coding gene Chr7:132102287-132121948 (+)



Homology
more
  • Human Ortholog
    FUS, FUS RNA binding protein
  • Vertebrate Orthologs
    4
  • Human Ortholog
    FUS, FUS RNA binding protein
    Orthology source: HGNC
  • Synonyms
    ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS
  • Links
    NCBI Gene ID: 2521
    neXtProt AC: NX_P35637
    UniProt: P35637

  • Chr Location
    16p11.2; chr16:31179444-31194871 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Fus mouse models; 2 with human FUS associations

Human Disease Mouse Models
      
IDs
View 5 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 7 alleles in 10 genetic backgrounds
    48 phenotypes from multigenic genotypes
    6 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233908 NCBI Gene Model | MGI Sequence Detail 15245 C57BL/6J ±  kb
    transcript NM_139149 RefSeq | MGI Sequence Detail 1845 C57BL/6  
    polypeptide NP_631888 RefSeq | MGI Sequence Detail 518 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 176
      cDNA 173
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2443475, MGI:2445182
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 18
      Diseases 5
      Gene Ontology 4
      Phenotypes 32
    • Earliest
      J:51309 Yang L, et al., Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem. 1998 Oct 23;273(43):27761-4
    • Latest
      J:260809 Zhang T, et al., FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Mol Cell. 2018 Mar 1;69(5):787-801.e8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory