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Fus
Gene Detail
 Symbol
Name
ID
Fus
fused in sarcoma
MGI:1353633
Synonyms D430004D17Rik, D930039C12Rik, hnRNP P2, pigpen, Tls, translocated in liposarcoma
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:127967457-127982368 bp, + strand
From VEGA annotation of GRCm38

  14912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3639  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: RNA-binding protein, EWS type
Gene Tree: Fus

Human
homologs
Human Homolog FUS, fused in sarcoma
NCBI Gene ID 2521
neXtProt AC  NX_P35637
Human Synonyms  ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS
Human Chr (Location)  16p11.2; chr16:31180110-31194871 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human FUS
Alleles
and
phenotypes
All alleles(27) : Targeted(7) Gene trapped(20)
 
Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Component cytoplasm, nucleus
Function DNA binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (257)    Tissues (230)    Images (29)
Theiler Stages: 10, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 241
Northern blot 4
Western blot 10
RT-PCR 2
cDNA source data(171)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(175) cDNA(172) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016476 (Evidence)
Ensembl Gene ModelENSMUSG00000030795 (Evidence)
Entrez Gene233908 (Evidence)
UniGene277680
NIA Mouse Gene IndexU008824, U065479
Consensus CDS ProjectCCDS21886.1
International Mouse Knockout Project StatusFus
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016476 VEGA Gene Model | MGI Sequence Detail 14912 C57BL/6J ±  kb
transcript OTTMUST00000039732 VEGA | MGI Sequence Detail 2203 Not Applicable 
polypeptide OTTMUSP00000017730 VEGA | MGI Sequence Detail 518 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(8) UniProt(8)
Polymorphisms SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
InterPro IPR001876 Zinc finger, RanBP2-type
Protein Ontology PR:000007700 RNA-binding protein FUS
References (Earliest) J:54190 Mencinger M, et al., Characterization of TFG in mus musculus and Caenorhabditis elegans. Biochem Biophys Res Commun. 1999 Apr 2;257(1):67-73
(Latest) J:201579 Panda SK, et al., Highly Efficient Targeted Mutagenesis in Mice Using TALENs. Genetics. 2013 Aug 26;
All references(55)
Other
accession IDs
MGI:2443475, MGI:2445182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory