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Fus Gene Detail
Summary
  • Symbol
    Fus
  • Name
    fused in sarcoma
  • Synonyms
    D430004D17Rik, D930039C12Rik, hnRNP P2, pigpen, Tls, translocated in liposarcoma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353633
    NCBI Gene: 233908
  • Gene Overview
    MyGene.info: FUS
Location & Maps
more
  • Sequence Map
    Chr7:127967457-127985701 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18245 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.87 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FUS, FUS RNA binding protein
  • Vertebrate Orthologs
    4
  • Human Ortholog
    FUS, FUS RNA binding protein
    Orthology source: HGNC
  • Synonyms
    ALS6, ETM4, FUS1, HNRNPP2, POMP75, TLS
  • Links
    NCBI Gene ID: 2521
    neXtProt AC: NX_P35637

  • Chr Location
    16p11.2; chr16:31179704-31194871 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human FUS associations

Human Disease Mouse Models
       Amyotrophic Lateral Sclerosis 6 with or without Frontotemporal Dementia;   OMIM: 608030 View 4 models
Tremor, Hereditary Essential, 4; ETM4   OMIM: 614782
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 3 alleles in 5 genetic backgrounds
    40 phenotypes from multigenic genotypes
    6 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    45
  • Endonuclease-mediated
    2
  • Gene trapped
    21
  • Targeted
    13
  • Transgenic
    9
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit impaired lymphocyte development, chromosomal instability, increased cellular radiation sensitivity, high neonatal mortality, and male sterility associated with lack of chromosomal pairing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016476 VEGA Gene Model | MGI Sequence Detail 18245 C57BL/6J ±  kb
transcript OTTMUST00000039732 VEGA | MGI Sequence Detail 5536 Not Applicable  
polypeptide OTTMUSP00000017730 VEGA | MGI Sequence Detail 518 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    107 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 175
    cDNA 172
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2443475, MGI:2445182
References
more
  • Summaries
    All 68
    Developmental Gene Expression 15
    Diseases 4
    Gene Ontology 3
    Phenotypes 25
  • Earliest
    J:54190 Mencinger M, et al., Characterization of TFG in mus musculus and Caenorhabditis elegans. Biochem Biophys Res Commun. 1999 Apr 2;257(1):67-73
  • Latest
    J:235148 Anderson DM, et al., Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):E4494-503

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory