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Slamf6 Gene Detail
Summary
  • Symbol
    Slamf6
  • Name
    SLAM family member 6
  • Synonyms
    KAL1, KAL1b, Ly108, NTB-A, SF2000
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353620
    NCBI Gene: 30925
  • Gene Overview
    MyGene.info: SLAMF6
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:171917515-171953170 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    239 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353620
protein coding gene Chr1:171917197-171953170 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016773
protein coding gene Chr1:177747465-177791073 (+)
A/J MGP_AJ_G0016752
protein coding gene Chr1:170483545-170519528 (+)
AKR/J MGP_AKRJ_G0016718
protein coding gene Chr1:175631917-175668504 (+)
BALB/cJ MGP_BALBcJ_G0016713
protein coding gene Chr1:171030146-171066874 (+)
C3H/HeJ MGP_C3HHeJ_G0016537
protein coding gene Chr1:176207251-176246509 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017175
protein coding gene Chr1:183652514-183689653 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014881
protein coding gene Chr1:162187514-162220408 (+)
CAST/EiJ MGP_CASTEiJ_G0016117
protein coding gene Chr1:175553822-175588925 (+)
CBA/J MGP_CBAJ_G0016511
protein coding gene Chr1:190192999-190226689 (+)
DBA/2J MGP_DBA2J_G0016618
protein coding gene Chr1:169424226-169459148 (+)
FVB/NJ MGP_FVBNJ_G0016615
protein coding gene Chr1:167678291-167713361 (+)
LP/J MGP_LPJ_G0016689
protein coding gene Chr1:178838188-178873465 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016642
protein coding gene Chr1:197461221-197497812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017211
protein coding gene Chr1:175489355-175530911 (+)
PWK/PhJ MGP_PWKPhJ_G0015903
protein coding gene Chr1:168791017-168826564 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015685
protein coding gene Chr1:174428120-174461634 (+)
WSB/EiJ MGP_WSBEiJ_G0016179
protein coding gene Chr1:175657809-175691329 (+)



Homology
more
  • Human Ortholog
    SLAMF6, SLAM family member 6
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLAMF6, SLAM family member 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD352, KALI, KALIb, Ly108, NTBA, NTB-A, SF2000
  • Links
    NCBI Gene ID: 114836
    neXtProt AC: NX_Q96DU3
    UniProt: Q96DU3

  • Chr Location
    1q23.2-q23.3; chr1:160485030-160523268 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele show no overt phenotype. Mice homozygous for another null allele show impaired IL-4 production by CD4+ T cells, reduced inflammatory response to L. mexicana infection, high susceptibility to S. typhimurium infection, and defective neutrophil bactericidal activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000015314 Ensembl Gene Model | MGI Sequence Detail 35656 C57BL/6J ±  kb
transcript ENSMUST00000195656 Ensembl | MGI Sequence Detail 5729 Not Applicable  
polypeptide ENSMUSP00000141448 Ensembl | MGI Sequence Detail 351 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
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  • All nucleic 24
    cDNA 23
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 51
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:60849 Peck SR, et al., Ly108: a new member of the mouse CD2 family of cell surface proteins. Immunogenetics. 2000 Nov;52(1-2):63-72
  • Latest
    J:251569 Radomir L, et al., T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP. J Immunol. 2017 Oct 15;199(8):2745-2757

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory