Slamf6
Gene Detail

Symbol Name ID

Slamf6 SLAM family member 6 MGI:1353620

Synonyms

KAL1, KAL1b, Ly108, NTB-A, SF2000

Feature Type

protein coding gene

Genetic Map

Chromosome 1

79.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr1:171917537-171943868 bp, + strand From NCBI annotation of GRCm38   26332 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Slamf6 ± 2 cM)

Gene Tree: Slamf6

Human ortholog

SLAMF6 SLAM family member 6 NCBI Gene ID 114836
Human Synonyms: CD352, KALI, KALIb, Ly108, NTBA, NTB-A, SF2000
Human Chr1:160454820-160493052 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for one null allele show no overt phenotype. Mice homozygous for another null allele show impaired IL-4 production by CD4+ T cells, reduced inflammatory response to L. mexicana infection, high susceptibility to S. typhimurium infection, and defective neutrophil bactericidal activity.

 

Gene Ontology (GO) classifications

All GO classifications: (6 annotations)

Component	integral to membrane, integral to plasma membrane, ...
Function	receptor activity

External Resources: FuncBase

Expression

cDNA source data(34)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) cDNA(34) Primer pair(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000015314 (Evidence)
Entrez Gene	30925 (Evidence)
UniGene	245727
DFCI	TC1585960, TC1590822, TC1608046, TC1628067
DoTS	DT.528075, DT.55144931, DT.99856506
NIA Mouse Gene Index	U001099
Consensus CDS Project	CCDS15504.1
International Mouse Knockout Project Status	Slamf6

Sequences

Length	Strain/Species
genomic	30925	NCBI Gene Model | MGI Sequence Detail	26332	C57BL/6J
transcript	NM_030710	RefSeq | MGI Sequence Detail	2443	C57BL/6
polypeptide	Q9ET39	UniProt | EBI | MGI Sequence Detail	351	Not Applicable

All sequences(36) RefSeq(2) UniProt(6)

Polymorphisms

PCR(1) : SNPs(103 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
InterPro	IPR015631	Signalling lymphocyte activation molecule family receptors
Protein Ontology	PR:000014913	SLAM family member 6

Graphical View of Protein Domain Structure

References

(Earliest) J:60849 Peck SR, et al., Ly108: a new member of the mouse CD2 family of cell surface proteins. Immunogenetics. 2000 Nov;52(1-2):63-72
(Latest) J:193308 Dutta M, et al., A role for ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol. 2013 Mar 1;190(5):2121-8
All references(39)