Zbtb18
Gene Detail

Symbol Name ID

Zbtb18 zinc finger and BTB domain containing 18 MGI:1353609

Synonyms

RP58, Zfp238

Feature Type

protein coding gene

Genetic Map

Chromosome 1

82.72 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:177444661-177450760 bp, + strand From Ensembl annotation of GRCm38   6100 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Zbtb18

Human homologs

Human Homolog		ZBTB18, zinc finger and BTB domain containing 18
NCBI Gene ID		10472
neXtProt AC		NX_Q99592
Human Synonyms		C2H2-171, RP58, TAZ-1, ZNF238
Human Chr (Location)		1q44-qter; chr1:244214561-244220778 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit neonatal lethality, cortical and hippocampal hypoplasia and laminar disorganization, and abnormal neuron apoptosis and cell cycling.

 
Human Diseases Modeled Using Mouse Zbtb18 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cerebellum development, cerebral cortex development, ...
Component	nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (305)    Tissues (230)    Images (72)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	296
RT-PCR	9

cDNA source data(107)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(110) cDNA(108) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000063659 (Evidence)
Entrez Gene	30928 (Evidence)
UniGene	468887
DFCI	TC1575739, TC1601549
DoTS	DT.101182655, DT.101387265, DT.110928632, DT.87069139, DT.99851287
NIA Mouse Gene Index	U001158
Consensus CDS Project	CCDS15553.1, CCDS35800.1
International Mouse Knockout Project Status	Zbtb18

Sequences

Length	Strain/Species
genomic	ENSMUSG00000063659	Ensembl Gene Model | MGI Sequence Detail	6100	C57BL/6J
transcript	ENSMUST00000094276	Ensembl | MGI Sequence Detail	3834	Not Applicable
polypeptide	ENSMUSP00000091831	Ensembl | MGI Sequence Detail	531	Not Applicable

All sequences(32) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013069	BTB/POZ
InterPro	IPR011333	BTB/POZ fold
InterPro	IPR000210	BTB/POZ-like
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000017773	zinc finger protein 238

References

(Earliest) J:60308 Meng G, et al., Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin. Gene. 2000 Jan 25;242(1-2):59-64
(Latest) J:184434 Xiang C, et al., RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion. Cell Death Differ. 2012 Apr;19(4):692-702
All references(36)