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Zbtb18
Gene Detail
Symbol

Name
ID
Zbtb18
zinc finger and BTB domain containing 18
MGI:1353609
Synonyms
RP58, Zfp238
Feature Type
protein coding gene
Genetic Map
Chromosome 1
82.72 cM, cytoband H3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:177444661-177450760 bp, + strand
From Ensembl annotation of GRCm38

  6100 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zbtb18

Human
homologs
Human Homolog ZBTB18, zinc finger and BTB domain containing 18
NCBI Gene ID 10472
neXtProt AC  NX_Q99592
Human Synonyms  C2H2-171, MRD22, RP58, TAZ-1, ZNF238
Human Chr (Location)  1q44; chr1:244048939-244057476 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ZBTB18
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality, cortical and hippocampal hypoplasia and laminar disorganization, and abnormal neuron apoptosis and cell cycling.
 
Human Diseases Modeled Using Mouse Zbtb18 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Zbtb18 interacts with 391 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cerebellum development, cerebral cortex development, ...
Component intercellular bridge, microtubule cytoskeleton, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (305)    Tissues (239)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 296
RT-PCR 9
cDNA source data(111)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(114) cDNA(112) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000063659 (Evidence)
Entrez Gene30928 (Evidence)
UniGene330700
DFCITC1575739, TC1601549
DoTSDT.101182655, DT.101387265, DT.110928632, DT.87069139, DT.99851287
NIA Mouse Gene IndexU001158
Consensus CDS ProjectCCDS15553.1, CCDS35800.1
International Mouse Knockout Project StatusZbtb18
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063659 Ensembl Gene Model | MGI Sequence Detail 6100 C57BL/6J ±  kb
transcript ENSMUST00000094276 Ensembl | MGI Sequence Detail 3834 Not Applicable 
polypeptide ENSMUSP00000091831 Ensembl | MGI Sequence Detail 531 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(20) UniProt(3)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017773 zinc finger and BTB domain-containing protein 18
References
(Earliest) J:60308 Meng G, et al., Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin. Gene. 2000 Jan 25;242(1-2):59-64
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(38)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory