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Mapk8ip3 Gene Detail
Summary
  • Symbol
    Mapk8ip3
  • Name
    mitogen-activated protein kinase 8 interacting protein 3
  • Synonyms
    c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, D17Wsu15e, Jip3, JNK-interacting protein 3, JSAP1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, JUN/SAPK-associated protein 1, mKIAA1066, sunday driver 2, Syd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353598
    NCBI Gene: 30957
  • Gene Overview
    MyGene.info: MAPK8IP3
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24897506-24936977 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    346 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353598
protein coding gene Chr17:24892153-24936977 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023330
protein coding gene Chr17:23917483-23963831 (-)
A/J MGP_AJ_G0023290
protein coding gene Chr17:23254272-23299814 (-)
AKR/J MGP_AKRJ_G0023257
protein coding gene Chr17:23342771-23391092 (-)
BALB/cJ MGP_BALBcJ_G0023295
protein coding gene Chr17:23454814-23500549 (-)
C3H/HeJ MGP_C3HHeJ_G0023055
protein coding gene Chr17:23708109-23754435 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023738
protein coding gene Chr17:24980463-25025273 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021213
protein coding gene Chr17:20714467-20757986 (-)
CAST/EiJ MGP_CASTEiJ_G0022557
protein coding gene Chr17:23562649-23609201 (-)
CBA/J MGP_CBAJ_G0023031
protein coding gene Chr17:25824872-25875626 (-)
DBA/2J MGP_DBA2J_G0023160
protein coding gene Chr17:22847109-22893167 (-)
FVB/NJ MGP_FVBNJ_G0023130
protein coding gene Chr17:22567466-22613097 (-)
LP/J MGP_LPJ_G0023237
protein coding gene Chr17:24222746-24269913 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023149
protein coding gene Chr17:25514160-25561530 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023776
protein coding gene Chr17:23627276-23673038 (-)
PWK/PhJ MGP_PWKPhJ_G0022306
protein coding gene Chr17:21602421-21647564 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022124
protein coding gene Chr17:21691588-21738181 (-)
WSB/EiJ MGP_WSBEiJ_G0022620
protein coding gene Chr17:23699845-23746094 (-)



Homology
more
  • Human Ortholog
    MAPK8IP3, mitogen-activated protein kinase 8 interacting protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK8IP3, mitogen-activated protein kinase 8 interacting protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JIP3, JIP-3, JSAP1, syd, SYD2
  • Links
    NCBI Gene ID: 23162
    neXtProt AC: NX_Q9UPT6
    UniProt: Q9UPT6

  • Chr Location
    16p13.3; chr16:1706183-1770317 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 4 alleles in 5 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in impaired lung morphogenesis, causes absence of the telencephalic commissure with multiple defects in brain development and axon guidance, may affect synaptic transmission, and invariably leads to neonatal death due to respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30957 NCBI Gene Model | MGI Sequence Detail 39472 C57BL/6J ±  kb
    transcript NM_013931 RefSeq | MGI Sequence Detail 5596 C57BL/6  
    polypeptide Q9ESN9 UniProt | EBI | MGI Sequence Detail 1337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR032486 JNK-interacting protein, leucine zipper II
      IPR019143 JNK/Rab-associated protein-1, N-terminal
      IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
      IPR034743 RH1 domain
      IPR034744 RH2 domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 25
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-33979, MGI:106287, MGI:2147106
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 12
      Gene Ontology 19
      Phenotypes 15
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:251170 Ma H, et al., JIP3 regulates neuronal radial migration by mediating TrkB axonal anterograde transport in the developing cerebral cortex. Biochem Biophys Res Commun. 2017 Apr 15;485(4):790-795

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory