Mapk8ip3
Gene Detail

Symbol Name ID

Mapk8ip3 mitogen-activated protein kinase 8 interacting protein 3 MGI:1353598

Synonyms

c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, D17Wsu15e, Jip3, JNK-interacting protein 3, JSAP1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, JUN/SAPK-associated protein 1, mKIAA1066, sunday driver 2, Syd2

Feature Type

protein coding gene

Genetic Map

Chromosome 17

12.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr17:24892153-24936968 bp, - strand From VEGA annotation of GRCm38   44816 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22790  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mapk8ip3

Human homologs

Human Homolog		MAPK8IP3, mitogen-activated protein kinase 8 interacting protein 3
NCBI Gene ID		23162
neXtProt AC		NX_Q9UPT6
Human Synonyms		JIP3, JSAP1, syd, SYD2
Human Chr (Location)		16p13.3; chr16:1756221-1820318 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygous inactivation of this gene results in impaired lung morphogenesis, causes absence of the telencephalic commissure with multiple defects in brain development and axon guidance, may affect synaptic transmission, and invariably leads to neonatal death due to respiratory failure.

 

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	activation of JUN kinase activity, axon guidance, ...
Component	axolemma, cell projection, ...
Function	JUN kinase binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (71)    Tissues (40)    Images (7)
Theiler Stages: 11, 23, 26, 28

Assay Type	Results
RNA in situ	26
Northern blot	11
Western blot	28
RT-PCR	6

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(24) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000030477 (Evidence)
Ensembl Gene Model	ENSMUSG00000024163 (Evidence)
Entrez Gene	30957 (Evidence)
NIA Mouse Gene Index	U037541, U234324
Consensus CDS Project	CCDS37498.1, CCDS50024.1, CCDS50025.1, CCDS50026.1, CCDS50027.1, CCDS50028.1, CCDS50029.1
International Mouse Knockout Project Status	Mapk8ip3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030477	VEGA Gene Model | MGI Sequence Detail	44816	C57BL/6J
transcript	OTTMUST00000075461	VEGA | MGI Sequence Detail	5543	Not Applicable
polypeptide	OTTMUSP00000039559	VEGA | MGI Sequence Detail	1337	Not Applicable

All sequences(128) RefSeq(14) UniProt(12)

Polymorphisms

SNPs within 2kb(388 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR019143	JNK/Rab-associated protein-1, N-terminal
InterPro	IPR011047	Quinonprotein alcohol dehydrogenase-like superfamily
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000010162	C-Jun-amino-terminal kinase-interacting protein 3

References

(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:176956 Ghosh AS, et al., DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J Cell Biol. 2011 Sep 5;194(5):751-64
All references(56)

Other accession IDs

MGD-MRK-33979, MGI:106287, MGI:2147106