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Mapk8ip3 Gene Detail
Summary
  • Symbol
    Mapk8ip3
  • Name
    mitogen-activated protein kinase 8 interacting protein 3
  • Synonyms
    c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, D17Wsu15e, Jip3, JNK-interacting protein 3, JSAP1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, JUN/SAPK-associated protein 1, mKIAA1066, sunday driver 2, Syd2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353598
    NCBI Gene: 30957
Location & Maps
more
  • Sequence Map
    Chr17:24892153-24936968 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44816 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    MAPK8IP3, mitogen-activated protein kinase 8 interacting protein 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK8IP3, mitogen-activated protein kinase 8 interacting protein 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    JIP3, JIP-3, JSAP1, syd, SYD2
  • Links
    NCBI Gene ID: 23162
    neXtProt AC: NX_Q9UPT6

  • Chr Location
    16p13.3; chr16:1706183-1770317 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    43 phenotypes from 4 alleles in 5 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Mapk8ip3
  • Incidental Mutations
Homozygous inactivation of this gene results in impaired lung morphogenesis, causes absence of the telencephalic commissure with multiple defects in brain development and axon guidance, may affect synaptic transmission, and invariably leads to neonatal death due to respiratory failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030477 VEGA Gene Model | MGI Sequence Detail 44816 C57BL/6J ±  kb
transcript OTTMUST00000075492 VEGA | MGI Sequence Detail 7278 Not Applicable  
polypeptide OTTMUSP00000039588 VEGA | MGI Sequence Detail 1337 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    388 from dbSNP Build 137
Protein
Information
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  • UniProt
    12 Sequences
  • InterPro Domains
    IPR032486 JNK-interacting protein, leucine zipper II
    IPR019143 JNK/Rab-associated protein-1, N-terminal
    IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 26
    cDNA 24
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-33979, MGI:106287, MGI:2147106
References
more
  • Summaries
    All 56
    Developmental Gene Expression 9
    Gene Ontology 14
    Phenotypes 12
  • Earliest
    J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
  • Latest
    J:226792 Sato T, et al., Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice. FEBS Lett. 2015 Sep 14;589(19 Pt B):2805-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory