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Mapk8ip3
Gene Detail
Symbol

Name
ID
Mapk8ip3
mitogen-activated protein kinase 8 interacting protein 3
MGI:1353598
Synonyms
c-Jun NH2-terminal kinase (JNK)/stress-activated protein kinase-associated protein 1, D17Wsu15e, Jip3, JNK-interacting protein 3, JSAP1, JSAP1a, JSAP1b, JSAP1c, JSAP1d, JUN/SAPK-associated protein 1, mKIAA1066, sunday driver 2, Syd2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr17:24892153-24936968 bp, - strand
From VEGA annotation of GRCm38

  44816 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22790  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mapk8ip3

Human
homologs
Human Homolog MAPK8IP3, mitogen-activated protein kinase 8 interacting protein 3
NCBI Gene ID 23162
neXtProt AC  NX_Q9UPT6
Human Synonyms  JIP3, JSAP1, syd, SYD2
Human Chr (Location)  16p13.3; chr16:1706183-1770317 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Radiation induced(1) Targeted(4)
Genomic Mutations involving Mapk8ip3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene results in impaired lung morphogenesis, causes absence of the telencephalic commissure with multiple defects in brain development and axon guidance, may affect synaptic transmission, and invariably leads to neonatal death due to respiratory failure.
 
Interactions
Mapk8ip3 interacts with 275 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process activation of JUN kinase activity, axon guidance, ...
Component axolemma, cell projection, ...
Function JUN kinase binding, kinesin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (71)    Tissues (40)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
Northern blot 11
Western blot 28
RT-PCR 6
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(24) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000030477 (Evidence)
Ensembl Gene ModelENSMUSG00000024163 (Evidence)
Entrez Gene30957 (Evidence)
NIA Mouse Gene IndexU037541, U234324
Consensus CDS ProjectCCDS37498.1, CCDS50024.1, CCDS50025.1, CCDS50026.1, CCDS50027.1, CCDS50028.1, CCDS50029.1
International Mouse Knockout Project StatusMapk8ip3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030477 VEGA Gene Model | MGI Sequence Detail 44816 C57BL/6J ±  kb
transcript OTTMUST00000075492 VEGA | MGI Sequence Detail 7278 Not Applicable 
polypeptide OTTMUSP00000039588 VEGA | MGI Sequence Detail 1337 Not Applicable 

For the selected sequences
All sequences(139) RefSeq(14) UniProt(23)
Polymorphisms
SNPs within 2kb(388 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019143 JNK/Rab-associated protein-1, N-terminal
InterPro IPR011047 Quinonprotein alcohol dehydrogenase-like superfamily
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000010162 C-Jun-amino-terminal kinase-interacting protein 3
References
(Earliest) J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
(Latest) J:199515 Sun T, et al., c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. J Biol Chem. 2013 May 17;288(20):14531-43
All references(58)
Other
accession IDs
MGD-MRK-33979, MGI:106287, MGI:2147106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory