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Mmp20
Gene Detail
 Symbol
Name
ID
Mmp20
matrix metallopeptidase 20 (enamelysin)
MGI:1353466
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:7628231-7674968 bp, + strand
From NCBI annotation of GRCm38

  46738 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21001  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp20

Human
homologs
Human Homolog MMP20, matrix metallopeptidase 20
NCBI Gene ID 9313
neXtProt AC  NX_O60882
Human Synonyms  AI2A2, MMP-20
Human Chr (Location)  11q22.3; chr11:102576835-102625332 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MMP20
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knockout allele exhibit a severe and profound tooth phenotype that includes altered amelogenin processing, enamel that delaminates from dentin, a hypoplastic enamel, a disorganized prism pattern, and a progressively deteriorating enamel morphology.
 
Human Diseases Modeled Using Mouse Mmp20 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Mmp20 interacts with 253 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process amelogenesis, extracellular matrix disassembly, ...
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (22)    Tissues (14)   
Theiler Stages: 22, 25, 28
Assay TypeResults
RNA in situ 3
Northern blot 9
RT-PCR 10
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000018620 (Evidence)
Entrez Gene30800 (Evidence)
UniGene390121
DFCITC1592626
DoTSDT.91279506
EC3.4.24.-
Consensus CDS ProjectCCDS22809.1
International Mouse Knockout Project StatusMmp20
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 30800 NCBI Gene Model | MGI Sequence Detail 46738 C57BL/6J ±  kb
transcript NM_013903 RefSeq | MGI Sequence Detail 3276 C57BL/6 
polypeptide P57748 UniProt | EBI | MGI Sequence Detail 482 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(395 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010480 matrix metalloproteinase-20
Graphical View of Protein Domain Structure
References (Earliest) J:60096 Caterina J, et al., Isolation, characterization, and chromosomal location of the mouse enamelysin gene. Genomics. 1999 Dec 1;62(2):308-11
(Latest) J:206207 Shin M, et al., Matrix Metalloproteinase-20 Over-Expression Is Detrimental to Enamel Development: A Mus musculus Model. PLoS One. 2014 Jan 23;9(1):e86774
All references(36)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.18
The Jackson Laboratory