Mmp20
Gene Detail

Symbol Name ID

Mmp20 matrix metallopeptidase 20 (enamelysin) MGI:1353466

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:7628231-7674968 bp, + strand From NCBI annotation of GRCm38   46738 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Mmp20 ± 2 cM)

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp20

Human ortholog

MMP20 matrix metallopeptidase 20 NCBI Gene ID 9313
Human Synonyms: AI2A2, MMP-20
Human Chr11:102447566-102496063 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human MMP20 (1)

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for a knockout allele exhibit a severe and profound tooth phenotype that includes altered amelogenin processing, enamel that delaminates from dentin, a hypoplastic enamel, a disorganized prism pattern, and a progressively deteriorating enamel morphology.

 
Human Diseases Modeled Using Mouse Mmp20 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	amelogenesis, proteolysis
Component	extracellular matrix, extracellular region, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (22)    Tissues (14)   
Theiler Stages: 22, 25, 28

Assay Type	Results
RNA in situ	3
Northern blot	9
RT-PCR	10

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) cDNA(5) Primer pair(2) Other(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000018620 (Evidence)
Entrez Gene	30800 (Evidence)
UniGene	390121
DFCI	TC1592626
DoTS	DT.91279506
EC	3.4.24.-
Consensus CDS Project	CCDS22809.1
International Mouse Knockout Project Status	Mmp20

Sequences

Length	Strain/Species
genomic	30800	NCBI Gene Model | MGI Sequence Detail	46738	C57BL/6J
transcript	NM_013903	RefSeq | MGI Sequence Detail	3276	C57BL/6
polypeptide	P57748	UniProt | EBI | MGI Sequence Detail	482	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs(356 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010480	matrix metalloproteinase-20

Graphical View of Protein Domain Structure

References

(Earliest) J:60096 Caterina J, et al., Isolation, characterization, and chromosomal location of the mouse enamelysin gene. Genomics. 1999 Dec 1;62(2):308-11
(Latest) J:188148 Landin MA, et al., Gene Expression Profiling during Murine Tooth Development. Front Genet. 2012;3:139
All references(34)