Phenotypes Associated with This Genotype

Genotype
MGI:2450776

• Allelic Composition: Mmp20^tm1Jdb/Mmp20^tm1Jdb
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enamel delaminates from the dentin surface in Mmp20^tm1Jdb/Mmp20^tm1Jdb mouse molars

craniofacial

abnormal tooth morphology ( J:80925 )

abnormal enamel morphology ( J:80925 )

• disorganized enamel protein structure

• the enamel that normally surrounds the cusps of molars is virtually absent and only the cervical margin of the tooth has enamel

abnormal ameloblast morphology ( J:80925 )

• during enamel development, ameloblasts become progressively more disorganized

abnormal enamel rod pattern ( J:80925 )

• the inner enamel layer shows a complete absence of the typical decussating rod pattern and enamel rod diameters are uneven

delaminated enamel ( J:80925 )

reduced enamel thickness ( J:80925 )

growth/size/body

abnormal tooth morphology ( J:80925 )

abnormal enamel morphology ( J:80925 )

• disorganized enamel protein structure

• the enamel that normally surrounds the cusps of molars is virtually absent and only the cervical margin of the tooth has enamel

abnormal ameloblast morphology ( J:80925 )

• during enamel development, ameloblasts become progressively more disorganized

abnormal enamel rod pattern ( J:80925 )

• the inner enamel layer shows a complete absence of the typical decussating rod pattern and enamel rod diameters are uneven

delaminated enamel ( J:80925 )

reduced enamel thickness ( J:80925 )

skeleton

abnormal tooth morphology ( J:80925 )

abnormal enamel morphology ( J:80925 )

• disorganized enamel protein structure

• the enamel that normally surrounds the cusps of molars is virtually absent and only the cervical margin of the tooth has enamel

abnormal ameloblast morphology ( J:80925 )

• during enamel development, ameloblasts become progressively more disorganized

abnormal enamel rod pattern ( J:80925 )

• the inner enamel layer shows a complete absence of the typical decussating rod pattern and enamel rod diameters are uneven

delaminated enamel ( J:80925 )

reduced enamel thickness ( J:80925 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amelogenesis imperfecta hypomaturation type 2A2		DOID:0110060	OMIM:612529	J:80925