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Mlh3
Gene Detail
Symbol

Name
ID
Mlh3
mutL homolog 3 (E coli)
MGI:1353455
Feature Type
protein coding gene
Genetic Map
Chromosome 12
39.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:85234529-85270591 bp, - strand
From Ensembl annotation of GRCm38

  36063 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:91153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MLH3
Gene Tree: Mlh3

Human
homologs
MLH3, mutL homolog 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 27030
neXtProt AC: NX_Q9UHC1

Human Synonyms: HNPCC7

Human Chr (Location): 14q24.3; chr14:75013764-75051532 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human MLH3

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are sterile. Both oocytes and spermatocytes exhibit meiotic block and die.
 
Interactions
Mlh3 interacts with 188 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to DNA damage stimulus, female meiosis I, ...
Component chiasma, condensed chromosome, ...
Function ATPase activity, centromeric DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (4)    Tissues (3)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 4
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN mlh3    NEW 
Molecular
reagents
All nucleic(51) cDNA(49) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021245 (Evidence)
Entrez Gene 217716 (Evidence)
UniGene 311981
DFCI TC1579712, TC1719237, TC1595893
DoTS DT.91429563, DT.102555526, DT.60110654, DT.99852685
NIA Mouse Gene Index U034182
Consensus CDS Project CCDS36497.1
International Mouse Phenotyping Consortium Status Mlh3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021245 Ensembl Gene Model | MGI Sequence Detail 36063 C57BL/6J ±  kb
transcript ENSMUST00000166821 Ensembl | MGI Sequence Detail 5420 Not Applicable 
polypeptide ENSMUSP00000129900 Ensembl | MGI Sequence Detail 1411 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(11) UniProt(7)
Polymorphisms
SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014762 DNA mismatch repair, conserved site
InterPro IPR013507 DNA mismatch repair protein, C-terminal
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR014790 MutL, C-terminal, dimerisation
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Protein Ontology PR:000010443 DNA mismatch repair protein Mlh3
References
(Earliest) J:59324 Lipkin SM, et al., MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Nat Genet. 2000 Jan;24(1):27-35
(Latest) J:215796 Holloway JK, et al., Mammalian CNTD1 is critical for meiotic crossover maturation and deselection of excess precrossover sites. J Cell Biol. 2014 Jun 9;205(5):633-41
All references(51)
Other
accession IDs
MGI:2144983, MGI:2145070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory