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Mlh3
Gene Detail
 Symbol
Name
ID
Mlh3
mutL homolog 3 (E coli)
MGI:1353455
Feature Type protein coding gene
Genetic Map
Chromosome 12
39.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:85234520-85270564 bp, - strand
From NCBI annotation of GRCm38

  36045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:91153  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mlh3

Human
homologs
Human Homolog MLH3, mutL homolog 3
NCBI Gene ID 27030
neXtProt AC  NX_Q9UHC1
Human Synonyms  HNPCC7
Human Chr (Location)  14q24.3; chr14:75013764-75051532 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human MLH3
Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Gene trapped(20) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are sterile. Both oocytes and spermatocytes exhibit meiotic block and die.
 
Interactions
Mlh3 interacts with 188 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process ATP catabolic process, cellular response to DNA damage stimulus, ...
Component chiasma, condensed chromosome, ...
Function ATPase activity, centromeric DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (4)    Tissues (3)    Images (2)
Theiler Stages: 1, 2, 28
Assay TypeResults
RT-PCR 4
cDNA source data(49)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(49) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021245 (Evidence)
Entrez Gene217716 (Evidence)
UniGene311981
DFCITC1579712, TC1595893
DoTSDT.102555526, DT.60110654, DT.91429563, DT.99852685
NIA Mouse Gene IndexU034182
Consensus CDS ProjectCCDS36497.1
International Mouse Knockout Project StatusMlh3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 217716 NCBI Gene Model | MGI Sequence Detail 36045 C57BL/6J ±  kb
transcript NM_175337 RefSeq | MGI Sequence Detail 5448 C57BL/6 
polypeptide NP_780546 RefSeq | MGI Sequence Detail 1411 C57BL/6 

For the selected sequences
All sequences(48) RefSeq(13) UniProt(7)
Polymorphisms SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014762 DNA mismatch repair, conserved site
InterPro IPR013507 DNA mismatch repair protein, C-terminal
InterPro IPR003594 Histidine kinase-like ATPase, ATP-binding domain
InterPro IPR014790 MutL, C-terminal, dimerisation
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
Protein Ontology PR:000010443 DNA mismatch repair protein Mlh3
References (Earliest) J:59324 Lipkin SM, et al., MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability. Nat Genet. 2000 Jan;24(1):27-35
(Latest) J:205585 Qiao H, et al., Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nat Genet. 2014 Feb;46(2):194-9
All references(49)
Other
accession IDs
MGI:2144983, MGI:2145070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory