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Aldh3a1
Gene Detail
Symbol

Name
ID
Aldh3a1
aldehyde dehydrogenase family 3, subfamily A1
MGI:1353451
Synonyms
Ahd4, Ahd-4, Aldh, Aldh3
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(21)
Sequence Map
Chr11:61207537-61218421 bp, + strand
From VEGA annotation of GRCm38

  10885 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20175  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: ALDH3A1
Protein SuperFamily: aldehyde dehydrogenase
Gene Tree: Aldh3a1

Human
homologs
ALDH3A1, aldehyde dehydrogenase 3 family, member A1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 218
neXtProt AC: NX_P30838

Human Synonyms: ALDH3, ALDHIII

Human Chr (Location): 17p11.2; chr17:19737984-19748433 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Genomic Mutations involving Aldh3a1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene does not result in a phenotype.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Aldh3a1 interacts with 34 markers (Mir128-1, Mir128-2, Mir138-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process cellular aldehyde metabolic process, metabolic process, ...
Component cytoplasm, cytosol, ...
Function 3-chloroallyl aldehyde dehydrogenase activity, alcohol dehydrogenase (NADP+) activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (106)    Tissues (106)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 99
RT-PCR 7
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005823 (Evidence)
Ensembl Gene Model ENSMUSG00000019102 (Evidence)
Entrez Gene 11670 (Evidence)
UniGene 4257
DFCI TC1580393
DoTS DT.101267303, DT.60118128
NIA Mouse Gene Index U012717
EC 1.2.1.5
Consensus CDS Project CCDS24808.1
International Mouse Phenotyping Consortium Status Aldh3a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005823 VEGA Gene Model | MGI Sequence Detail 10885 C57BL/6J ±  kb
transcript OTTMUST00000012918 VEGA | MGI Sequence Detail 1729 Not Applicable 
polypeptide OTTMUSP00000006008 VEGA | MGI Sequence Detail 453 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(16) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003926 aldehyde dehydrogenase, dimeric NADP-preferring
References
(Earliest) J:6092 Lush IE, Genetic variation of some aldehyde-oxidizing enzymes in the mouse. Anim Blood Groups Biochem Genet. 1978;9(2):85-96
(Latest) J:218413 Kitamura T, et al., Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets via two C-terminal tryptophan residues and lipid modification. Biochem J. 2015 Jan 1;465(1):79-87
All references(69)
Other
accession IDs
MGD-MRK-1209, MGD-MRK-1216, MGD-MRK-1275, MGD-MRK-16381, MGI:87993, MGI:99599

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory