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Aldh3a1 Gene Detail
Summary
  • Symbol
    Aldh3a1
  • Name
    aldehyde dehydrogenase family 3, subfamily A1
  • Synonyms
    Ahd4, Ahd-4, Aldh, Aldh3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353451
    NCBI Gene: 11670
Location & Maps
more
  • Sequence Map
    Chr11:61207537-61218421 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10885 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 37.96 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    21 experiments
Homology
more
  • Human Ortholog
    ALDH3A1, aldehyde dehydrogenase 3 family member A1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ALDH3A1, aldehyde dehydrogenase 3 family member A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALDH3, ALDHIII
  • Links
    NCBI Gene ID: 218
    neXtProt AC: NX_P30838

  • Chr Location
    17p11.2; chr17:19737984-19748433 (-)  GRCh38.p2

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Aldh3a1
  • Incidental Mutations
Homozygous mutation of this gene does not result in a phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005823 VEGA Gene Model | MGI Sequence Detail 10885 C57BL/6J ±  kb
transcript OTTMUST00000012919 VEGA | MGI Sequence Detail 1721 Not Applicable  
polypeptide OTTMUSP00000006009 VEGA | MGI Sequence Detail 453 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003926 aldehyde dehydrogenase, dimeric NADP-preferring
  • EC
  • InterPro Domains
    IPR016163 Aldehyde dehydrogenase, C-terminal
    IPR016160 Aldehyde dehydrogenase, cysteine active site
    IPR015590 Aldehyde dehydrogenase domain
    IPR029510 Aldehyde dehydrogenase, glutamic acid active site
    IPR012394 Aldehyde dehydrogenase NAD(P)-dependent
    IPR016162 Aldehyde dehydrogenase N-terminal domain
    IPR016161 Aldehyde/histidinol dehydrogenase
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1209, MGD-MRK-1216, MGD-MRK-1275, MGD-MRK-16381, MGI:87993, MGI:99599
References
more
  • Summaries
    All 69
    Developmental Gene Expression 7
    Diseases 2
    Gene Ontology 11
    Phenotypes 23
  • Earliest
    J:6092 Lush IE, Genetic variation of some aldehyde-oxidizing enzymes in the mouse. Anim Blood Groups Biochem Genet. 1978;9(2):85-96
  • Latest
    J:228662 Nishiyama M, et al., FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Stem Cells. 2015 Nov;33(11):3327-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory