Aldh3a1 MGI Mouse Gene Detail - MGI:1353451 - aldehyde dehydrogenase family 3, subfamily A1

Symbol

Aldh3a1
Name

aldehyde dehydrogenase family 3, subfamily A1
Synonyms

Ahd-4, Ahd4, Aldh, Aldh3

Feature Type

protein coding gene
IDs

MGI:1353451
NCBI Gene: 11670
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:61099336-61109244 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 37.96 cM
Mapping Data

21 experiments

SNPs within 2kb

436 from dbSNP Build 142
Strain Annotations

28
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1353451	protein coding gene	Chr11:61098363-61109247 (+)
129S1/SvImJ	ENSMUSG00200036432	protein coding gene	Chr11:58023012-58033893 (+)
A/J	ENSMUSG00195037439	protein coding gene	Chr11:58062329-58062435 (+)
A/J	ENSMUSGG00195055038	protein coding gene	Chr11:58063558-58068863 (+)
AKR/J	ENSMUSGG00220054840	protein coding gene	Chr11:58171021-58176323 (+)
AKR/J	ENSMUSG00220047994	protein coding gene	Chr11:58169792-58169898 (+)
BALB/cJ	ENSMUSGG00180055579	protein coding gene	Chr11:58116969-58122274 (+)
BALB/cJ	ENSMUSG00180049379	protein coding gene	Chr11:58115740-58115846 (+)
C3H/HeJ	ENSMUSGG00175055081	protein coding gene	Chr11:58080800-58086105 (+)
C3H/HeJ	ENSMUSG00175035229	protein coding gene	Chr11:58079571-58079677 (+)
C57BL/6NJ	ENSMUSGG00215055300	protein coding gene	Chr11:57823730-57829035 (+)
C57BL/6NJ	ENSMUSG00215037744	protein coding gene	Chr11:57822501-57822607 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016472	protein coding gene	Chr11:56037298-56048324 (+)
CAST/EiJ	ENSTCUGG00005054403	protein coding gene	Chr11:57611911-57617229 (+)
CBA/J	ENSMUSG00210030488	protein coding gene	Chr11:57912616-57912722 (+)
CBA/J	ENSMUSGG00210054654	protein coding gene	Chr11:57913845-57919150 (+)
DBA/2J	ENSMUSG00185042525	protein coding gene	Chr11:58102048-58102154 (+)
DBA/2J	ENSMUSGG00185057513	protein coding gene	Chr11:58103277-58108581 (+)
FVB/NJ	ENSMUSG00205041243	protein coding gene	Chr11:57982283-57993135 (+)
JF1/MsJ	ENSUMUGG00000058214	protein coding gene	Chr11:58514607-58519926 (+)
LP/J	ENSMUSGG00230055792	protein coding gene	Chr11:59250214-59255516 (+)
LP/J	ENSMUSG00230046936	protein coding gene	Chr11:59248985-59249091 (+)
NOD/ShiLtJ	ENSMUSGG00190054658	protein coding gene	Chr11:58097493-58102797 (+)
NOD/ShiLtJ	ENSMUSG00190051200	protein coding gene	Chr11:58096264-58096370 (+)
NZO/HlLtJ	ENSMUSG00225047113	protein coding gene	Chr11:61387776-61398658 (+)
PWK/PhJ	ENSLUMGG00010054321	protein coding gene	Chr11:58036143-58041441 (+)
SPRET/EiJ	ENSMSPG00010029887	protein coding gene	Chr11:58700771-58710459 (+)
WSB/EiJ	ENSIUOG00005033940	protein coding gene	Chr11:58015005-58025857 (+)

Human Ortholog

ALDH3A1, aldehyde dehydrogenase 3 family member A1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ALDH3A1, aldehyde dehydrogenase 3 family member A1
Synonyms

ALDH3, ALDHIII
Links

HGNC:405

NCBI Gene ID: 218

UniProt: P30838
Chr Location

17p11.2; chr17:19737984-19748943 (-) GRCh38

MGI Vertebrate Homology

Aldh3a1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ALDH3A1
Protein SuperFamily

ALDH
Gene Tree

Aldh3a1

Diseases

1 with human ALDH3A1 associations

				Human Disease	Mouse Models
				arteriosclerosis IDs arteriosclerosis DOID:2349 ICD10CM:I70 MESH:D001161 NCI:C34398 UMLS_CUI:C0003850

Click on a disease name to see all genes associated with that disease.

References

2 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
30 phenotype references

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Targeted

5
Genomic Mutations

3 involving Aldh3a1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutation of this gene does not result in a phenotype.

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All GO Annotations

55
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

722
Tissues

118
cDNA Data

11
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN aldh3a1

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All Sequences

66
RefSeq

14
UniProt

4
CCDS

CCDS24808.1

Ensembl

ENSMUSG00000019102 (Evidence)
NCBI Gene

11670

			Length	Strain/Species	Flank
genomic	11670	NCBI Gene Model \| MGI Sequence Detail	9909	C57BL/6J	± kb
transcript	NM_001331112	RefSeq \| MGI Sequence Detail	1732	ZRU/MplStud
polypeptide	P47739	UniProt \| EBI \| MGI Sequence Detail	453	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003926 aldehyde dehydrogenase, dimeric NADP-preferring

(term hierarchy)
EC

1.2.1.5
InterPro Domains

IPR016163 Aldehyde dehydrogenase, C-terminal

IPR016160 Aldehyde dehydrogenase, cysteine active site

IPR015590 Aldehyde dehydrogenase domain

IPR029510 Aldehyde dehydrogenase, glutamic acid active site

IPR012394 Aldehyde dehydrogenase NAD(P)-dependent

IPR016162 Aldehyde dehydrogenase, N-terminal

IPR016161 Aldehyde/histidinol dehydrogenase

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All nucleic 14

cDNA 11

Primer pair 3

Antibodies 1

Microarray probesets 3

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MGD-MRK-1209, MGD-MRK-1216, MGD-MRK-1275, MGD-MRK-16381, MGI:87993, MGI:99599

Summaries

All 110

Developmental Gene Expression 11

Diseases 2

Gene Ontology 16

Phenotypes 30
Earliest

J:6092 Lush IE, Genetic variation of some aldehyde-oxidizing enzymes in the mouse. Anim Blood Groups Biochem Genet. 1978;9(2):85-96
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Aldh3a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101946	Chr11:61099560-61099573 (+)	231 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24