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Aldh1a1 Gene Detail
Summary
  • Symbol
    Aldh1a1
  • Name
    aldehyde dehydrogenase family 1, subfamily A1
  • Synonyms
    Ahd2, Ahd-2, ALDH1, E1, Raldh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353450
    NCBI Gene: 11668
  • Gene Overview
    MyGene.info: ALDH1A1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:20601961-20643462 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41502 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 13.91 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    ALDH1A1, aldehyde dehydrogenase 1 family member A1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ALDH1A1, aldehyde dehydrogenase 1 family member A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALDC, ALDH1, ALDH11, ALDH-E1, HEL12, HEL-9, HEL-S-53e, PUMB1, RALDH1
  • Links
    NCBI Gene ID: 216
    neXtProt AC: NX_P00352
    UniProt: P00352

  • Chr Location
    9q21.13; chr9:72900662-72953317 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene show a significantly reduced ability to convert retinol to retinoic acid in the liver. Retinal morphology is normal even though the gene is normally highly expressed in the dorsal retina.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021238 VEGA Gene Model | MGI Sequence Detail 41502 C57BL/6J ±  kb
    transcript OTTMUST00000050305 VEGA | MGI Sequence Detail 2053 Not Applicable  
    polypeptide OTTMUSP00000023466 VEGA | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      768 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 234
      Genomic 3
      cDNA 211
      Primer pair 13
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-1206, MGD-MRK-1213, MGD-MRK-16383, MGI:99601
    References
    more
    • Summaries
      All 187
      Developmental Gene Expression 101
      Gene Ontology 15
      Phenotypes 32
    • Earliest
      J:5870 Theriault LL, et al., Lipid and myelin abnormalities of brain in the crinkled mouse. Proc Soc Exp Biol Med. 1977 Sep;155(4):549-53
    • Latest
      J:264149 Goto S, et al., Neural retina-specific Aldh1a1 controls dorsal choroidal vascular development via Sox9 expression in retinal pigment epithelial cells. Elife. 2018 Apr 3;7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory