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Aldh1a1
Gene Detail
 Symbol
Name
ID
Aldh1a1
aldehyde dehydrogenase family 1, subfamily A1
MGI:1353450
Synonyms Ahd2, Ahd-2, ALDH1, E1, Raldh1
Feature Type protein coding gene
Genetic Map
Chromosome 19
13.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr19:20601961-20643462 bp, + strand
From VEGA annotation of GRCm38

  41502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:110441  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh1a1

Human
homologs
Human Homolog ALDH1A1, aldehyde dehydrogenase 1 family, member A1
NCBI Gene ID 216
neXtProt AC  NX_P00352
Human Synonyms  ALDC, ALDH1, ALDH11, ALDH-E1, HEL12, HEL-9, HEL-S-53e, PUMB1, RALDH1
Human Chr (Location)  9q21.13; chr9:72900662-72953317 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene show a significantly reduced ability to convert retinol to retinoic acid in the liver. Retinal morphology is normal even though the gene is normally highly expressed in the dorsal retina.
 
Interactions
Aldh1a1 interacts with 103 markers (Mir17, Mir20b, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process 9-cis-retinoic acid biosynthetic process, 9-cis-retinoic acid metabolic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function 3-chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (84 records)
Data Summary: Results (294)    Tissues (211)    Images (98)
Theiler Stages: 1, 3, 4, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 31
RNA in situ 205
RT-PCR 58
cDNA source data(206)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(230) Genomic(3) cDNA(209) Primer pair(12) Other(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021238 (Evidence)
Ensembl Gene ModelENSMUSG00000053279 (Evidence)
Entrez Gene11668 (Evidence)
UniGene250866
DFCITC1572688
DoTSDT.496342
EC1.2.1.36
Consensus CDS ProjectCCDS29695.1
International Mouse Knockout Project StatusAldh1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021238 VEGA Gene Model | MGI Sequence Detail 41502 C57BL/6J ±  kb
transcript OTTMUST00000050305 VEGA | MGI Sequence Detail 2053 Not Applicable 
polypeptide OTTMUSP00000023466 VEGA | MGI Sequence Detail 501 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms RFLP(3) : SNPs within 2kb(779 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016160 Aldehyde dehydrogenase, conserved site
InterPro IPR016163 Aldehyde dehydrogenase, C-terminal
InterPro IPR015590 Aldehyde dehydrogenase domain
InterPro IPR016162 Aldehyde dehydrogenase, N-terminal
InterPro IPR016161 Aldehyde/histidinol dehydrogenase
Protein Ontology PR:000003920 retinal dehydrogenase 1
References (Earliest) J:6127 Holmes RS, Genetics and ontogeny of aldehyde dehydrogenase isozymes in the mouse: localization of Ahd-1 encoding the mitochondrial isozyme on chromosome 4. Biochem Genet. 1978 Dec;16(11-12):1207-18
(Latest) J:208599 Mcilroy GD, et al., Fenretinide treatment prevents diet-induced obesity in association with major alterations in retinoid homeostatic gene expression in adipose, liver, and hypothalamus. Diabetes. 2013 Mar;62(3):825-36
All references(155)
Other
accession IDs
MGD-MRK-1206, MGD-MRK-1213, MGD-MRK-16383, MGI:99601

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory