Aldh1a1
Gene Detail

Symbol Name ID

Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 MGI:1353450

Synonyms

Ahd2, Ahd-2, ALDH1, E1, Raldh1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

13.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr19:20601961-20643462 bp, + strand From VEGA annotation of GRCm38   41502 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:110441  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: NAD-dependent aldehyde dehydrogenase
Gene Tree: Aldh1a1

Human homologs

Human Homolog		ALDH1A1, aldehyde dehydrogenase 1 family, member A1
NCBI Gene ID		216
neXtProt AC		NX_P00352
Human Synonyms		ALDC, ALDH1, ALDH11, ALDH-E1, PUMB1, RALDH1
Human Chr (Location)		9q21.13; chr9:75515578-75568233 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a disruption in this gene show a significantly reduced ability to convert retinol to retinoic acid in the liver. Retinal morphology is normal even though the gene is normally highly expressed in the dorsal retina.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	9-cis-retinoic acid biosynthetic process, 9-cis-retinoic acid metabolic process, ...
Component	cytoplasm, nucleus
Function	3-chloroallyl aldehyde dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (78 records)
Data Summary: Results (245)    Tissues (194)    Images (70)
Theiler Stages: 1, 3, 4, 9, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	31
RNA in situ	180
RT-PCR	34

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(3) cDNA(27) Primer pair(8) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021238 (Evidence)
Ensembl Gene Model	ENSMUSG00000053279 (Evidence)
Entrez Gene	11668 (Evidence)
DFCI	TC1572688
DoTS	DT.496342
EC	1.2.1.36
Consensus CDS Project	CCDS29695.1
International Mouse Knockout Project Status	Aldh1a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021238	VEGA Gene Model | MGI Sequence Detail	41502	C57BL/6J
transcript	OTTMUST00000050305	VEGA | MGI Sequence Detail	2053	Not Applicable
polypeptide	OTTMUSP00000023466	VEGA | MGI Sequence Detail	501	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(3) : SNPs(322 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016160	Aldehyde dehydrogenase, conserved site
InterPro	IPR016163	Aldehyde dehydrogenase, C-terminal
InterPro	IPR015590	Aldehyde dehydrogenase domain
InterPro	IPR016162	Aldehyde dehydrogenase, N-terminal
InterPro	IPR016161	Aldehyde/histidinol dehydrogenase
Protein Ontology	PR:000003920	retinal dehydrogenase 1

References

(Earliest) J:6127 Holmes RS, Genetics and ontogeny of aldehyde dehydrogenase isozymes in the mouse: localization of Ahd-1 encoding the mitochondrial isozyme on chromosome 4. Biochem Genet. 1978 Dec;16(11-12):1207-18
(Latest) J:191504 Gasparetto M, et al., Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development. Exp Hematol. 2012 Apr;40(4):318-29.e2
All references(140)

Other accession IDs

MGD-MRK-1206, MGD-MRK-1213, MGD-MRK-16383, MGI:99601