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Aldh1a1 Gene Detail
Summary
  • Symbol
    Aldh1a1
  • Name
    aldehyde dehydrogenase family 1, subfamily A1
  • Synonyms
    Ahd2, Ahd-2, ALDH1, E1, Raldh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353450
    NCBI Gene: 11668
  • Gene Overview
    MyGene.info: ALDH1A1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:20601982-20643462 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 13.91 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    767 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353450
protein coding gene Chr19:20492715-20643462 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024973
protein coding gene Chr19:18597635-18644400 (+)
A/J MGP_AJ_G0024950
protein coding gene Chr19:17576509-17619326 (+)
AKR/J MGP_AKRJ_G0024920
protein coding gene Chr19:18243180-18284818 (+)
BALB/cJ MGP_BALBcJ_G0024949
protein coding gene Chr19:17594173-17638319 (+)
C3H/HeJ MGP_C3HHeJ_G0024707
protein coding gene Chr19:18205708-18248036 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025391
protein coding gene Chr19:19246238-19291523 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022810
protein coding gene Chr19:17872113-17913217 (+)
CAST/EiJ MGP_CASTEiJ_G0024175
protein coding gene Chr19:17855065-17897662 (+)
CBA/J MGP_CBAJ_G0024685
protein coding gene Chr19:20011825-20058539 (+)
DBA/2J MGP_DBA2J_G0024817
protein coding gene Chr19:17588749-17632928 (+)
FVB/NJ MGP_FVBNJ_G0024778
protein coding gene Chr19:17453427-17495887 (+)
LP/J MGP_LPJ_G0024901
protein coding gene Chr19:18550713-18594122 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024805
protein coding gene Chr19:20149646-20195374 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025446
protein coding gene Chr19:18205063-18246514 (+)
PWK/PhJ MGP_PWKPhJ_G0023924
protein coding gene Chr19:17121752-17163989 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023729
protein coding gene Chr19:17475265-17516667 (+)
WSB/EiJ MGP_WSBEiJ_G0024243
protein coding gene Chr19:18255923-18305414 (+)



Homology
more
  • Human Ortholog
    ALDH1A1, aldehyde dehydrogenase 1 family member A1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ALDH1A1, aldehyde dehydrogenase 1 family member A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALDC, ALDH1, ALDH11, ALDH-E1, HEL12, HEL-9, HEL-S-53e, PUMB1, RALDH1
  • Links
    NCBI Gene ID: 216
    neXtProt AC: NX_P00352
    UniProt: P00352

  • Chr Location
    9q21.13; chr9:72900662-72953317 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    20 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene show a significantly reduced ability to convert retinol to retinoic acid in the liver. Retinal morphology is normal even though the gene is normally highly expressed in the dorsal retina.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11668 NCBI Gene Model | MGI Sequence Detail 41481 C57BL/6J ±  kb
    transcript NM_001361503 RefSeq | MGI Sequence Detail 2991 C57BL/6  
    polypeptide P24549 UniProt | EBI | MGI Sequence Detail 501 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 234
      Genomic 3
      cDNA 211
      Primer pair 13
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1206, MGD-MRK-1213, MGD-MRK-16383, MGI:99601
    References
    more
    • Summaries
      All 188
      Developmental Gene Expression 102
      Gene Ontology 16
      Phenotypes 32
    • Earliest
      J:5870 Theriault LL, et al., Lipid and myelin abnormalities of brain in the crinkled mouse. Proc Soc Exp Biol Med. 1977 Sep;155(4):549-53
    • Latest
      J:265050 Chleilat E, et al., TGF-beta Signaling Regulates Development of Midbrain Dopaminergic and Hindbrain Serotonergic Neuron Subgroups. Neuroscience. 2018 Jun 15;381:124-137

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory