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Eif2ak2 Gene Detail
Summary
  • Symbol
    Eif2ak2
  • Name
    eukaryotic translation initiation factor 2-alpha kinase 2
  • Synonyms
    2310047A08Rik, 4732414G15Rik, dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, Pkr, Prkr, Tik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353449
    NCBI Gene: 19106
  • Gene Overview
    MyGene.info: EIF2AK2
Location & Maps
more
  • Sequence Map
    Chr17:78852564-78882573 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30010 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 49.56 cM, cytoband E2
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    EIF2AK2, eukaryotic translation initiation factor 2 alpha kinase 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EIF2AK2, eukaryotic translation initiation factor 2 alpha kinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EIF2AK1, PKR, PPP1R83, PRKR
  • Links
    NCBI Gene ID: 5610
    neXtProt AC: NX_P19525

  • Chr Location
    2p22-p21; chr2:37104683-37157065 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    5
  • Targeted
    5
  • Transgenic
    3
  • Incidental Mutations
Mice homozygous for disruptions in this gene display altered susceptibility to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036019 VEGA Gene Model | MGI Sequence Detail 30010 C57BL/6J ±  kb
transcript OTTMUST00000092432 VEGA | MGI Sequence Detail 4313 Not Applicable  
polypeptide OTTMUSP00000051089 VEGA | MGI Sequence Detail 515 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    276 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006959 interferon-induced, double-stranded RNA-activated protein kinase
  • PDB
  • EC
  • InterPro Domains
    IPR014720 Double-stranded RNA-binding domain
    IPR033366 Interferon-induced, double-stranded RNA-activated protein kinase
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 45
    Genomic 5
    cDNA 38
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-13612, MGD-MRK-15108, MGI:1924009, MGI:2146878, MGI:2146919, MGI:97761, MGI:98750
References
more
  • Summaries
    All 126
    Developmental Gene Expression 2
    Gene Ontology 18
    Phenotypes 61
  • Earliest
    J:43390 Icely PL, et al., TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem. 1991 Aug 25;266(24):16073-7
  • Latest
    J:228250 Nakamura T, et al., A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2alpha phosphorylation in obesity. Cell Rep. 2015 Apr 14;11(2):295-307

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory