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Eif2ak2
Gene Detail
Symbol

Name
ID
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
MGI:1353449
Synonyms
2310047A08Rik, 4732414G15Rik, dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, Pkr, Prkr, Tik
Feature Type
protein coding gene
Genetic Map
Chromosome 17
49.56 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr17:78852564-78882573 bp, - strand
From VEGA annotation of GRCm38

  30010 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: EIF2AK2
Protein SuperFamily: protein kinase TIK
Gene Tree: Eif2ak2

Human
homologs
EIF2AK2, eukaryotic translation initiation factor 2-alpha kinase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5610
neXtProt AC: NX_P19525

Human Synonyms: EIF2AK1, PKR, PPP1R83, PRKR

Human Chr (Location): 2p22-p21; chr2:37104683-37157065 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display altered susceptibility to viral infection.
 
Interactions
Eif2ak2 interacts with 255 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process activation of MAPKK activity, defense response to virus, ...
Component cytoplasm, membrane, ...
Function ATP binding, double-stranded RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (34)    Tissues (34)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 20
RT-PCR 14
cDNA source data(38)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase eif2ak2    NEW 
Molecular
reagents
All nucleic(45) Genomic(5) cDNA(38) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000036019 (Evidence)
Ensembl Gene Model ENSMUSG00000024079 (Evidence)
Entrez Gene 19106 (Evidence)
UniGene 378990
DFCI TC1659639, TC1629815, TC1585532, TC1623067
DoTS DT.101343338, DT.40185952
NIA Mouse Gene Index U038070
EC 2.7.11.1, 2.7.10.2
PDB 1X49, 1X48
Consensus CDS Project CCDS28980.1
International Mouse Phenotyping Consortium Status Eif2ak2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036019 VEGA Gene Model | MGI Sequence Detail 30010 C57BL/6J ±  kb
transcript OTTMUST00000092432 VEGA | MGI Sequence Detail 4313 Not Applicable 
polypeptide OTTMUSP00000051089 VEGA | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(279 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014720 Double-stranded RNA-binding-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000006959 interferon-induced, double-stranded RNA-activated protein kinase
References
(Earliest) J:43390 Icely PL, et al., TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem. 1991 Aug 25;266(24):16073-7
(Latest) J:214498 Ogolla PS, et al., The protein kinase double-stranded RNA-dependent (PKR) enhances protection against disease cause by a non-viral pathogen. PLoS Pathog. 2013;9(8):e1003557
All references(123)
Other
accession IDs
MGD-MRK-13612, MGD-MRK-15108, MGI:1924009, MGI:2146878, MGI:2146919, MGI:97761, MGI:98750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory