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Eif2ak2
Gene Detail
 Symbol
Name
ID
Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
MGI:1353449
Synonyms 2310047A08Rik, 4732414G15Rik, dsRNA-activated kinase, eIF-2 alpha, eIF-2 alpha, IFN-induced and double-stranded RNA-activated kinase, IFN- type I-induced and dsRNA-activated kinase, Pkr, Prkr, Tik
Feature Type protein coding gene
Genetic Map
Chromosome 17
49.56 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr17:78852564-78882573 bp, - strand
From VEGA annotation of GRCm38

  30010 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48134  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein kinase TIK
Gene Tree: Eif2ak2

Human
homologs
Human Homolog EIF2AK2, eukaryotic translation initiation factor 2-alpha kinase 2
NCBI Gene ID 5610
neXtProt AC  NX_P19525
Human Synonyms  EIF2AK1, PKR, PPP1R83, PRKR
Human Chr (Location)  2p22-p21; chr2:37105138-37157047 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display altered susceptibility to viral infection.
 
Interactions
Eif2ak2 interacts with 256 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process activation of MAPKK activity, defense response to virus, ...
Component cytoplasm, membrane, ...
Function ATP binding, double-stranded RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (34)    Tissues (33)    Images (4)
Theiler Stages: 10, 18, 21, 23, 25, 28
Assay TypeResults
RNA in situ 20
RT-PCR 14
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) Genomic(5) cDNA(38) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036019 (Evidence)
Ensembl Gene ModelENSMUSG00000024079 (Evidence)
Entrez Gene19106 (Evidence)
UniGene378990
DFCITC1585532, TC1623067, TC1629815, TC1659639
DoTSDT.101343338, DT.40185952
NIA Mouse Gene IndexU038070
EC2.7.10.2, 2.7.11.1
PDB1X48, 1X49
Consensus CDS ProjectCCDS28980.1
International Mouse Knockout Project StatusEif2ak2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036019 VEGA Gene Model | MGI Sequence Detail 30010 C57BL/6J ±  kb
transcript OTTMUST00000092432 VEGA | MGI Sequence Detail 4313 Not Applicable 
polypeptide OTTMUSP00000051089 VEGA | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(279 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014720 Double-stranded RNA-binding-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000006959 interferon-induced, double-stranded RNA-activated protein kinase
References (Earliest) J:43390 Icely PL, et al., TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem. 1991 Aug 25;266(24):16073-7
(Latest) J:206139 Lourenco MV, et al., TNF-alpha mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's beta-amyloid oligomers in mice and monkeys. Cell Metab. 2013 Dec 3;18(6):831-43
All references(128)
Other
accession IDs
MGD-MRK-13612, MGD-MRK-15108, MGI:1924009, MGI:2146878, MGI:2146919, MGI:97761, MGI:98750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory