Eif2ak2 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Eif2ak2
eukaryotic translation initiation factor 2-alpha kinase 2
MGI:1353449

21 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Adar^em1Stsn/Adar^tm1Olds Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe involves: 129S/SvEv * 129S4/SvJae * C57BL/6J	abnormal homeostasis	J:308678
	growth/size/body region phenotype	J:308678
	homeostasis/metabolism phenotype	J:308678
	mortality/aging	J:308678
Eif2ak2^em1Btlr/Eif2ak2^em1Btlr Zfp574^em1Btlr/Zfp574^em1Btlr C57BL/6J-Zfp574^em1Btlr Eif2ak2^em1Btlr	abnormal B cell physiology	J:354285
	abnormal class switch recombination	J:354285
	abnormal hematopoietic system morphology/development	J:354285
	abnormal humoral immune response	J:354285
	decreased erythrocyte cell number	J:354285
	decreased lymphocyte cell number	J:354285
	macrocytic anemia	J:354285
	pancytopenia	J:354285
Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Hdac8^tm1.2Eno/Y involves: 129/Sv * 129S6/SvEvTac * C57BL/6J	abnormal limb morphology	J:297059
	postnatal lethality, incomplete penetrance	J:297059
Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Nipbl^{Gt(RRS564)Byg}/Nipbl⁺ involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1	abnormal bone ossification	J:297059
	abnormal chromosome number	J:297059
	abnormal DNA repair	J:297059
	abnormal placenta junctional zone morphology	J:297059
	abnormal spongiotrophoblast cell morphology	J:297059
	abnormal trophoblast glycogen cell morphology	J:297059
	postnatal lethality, incomplete penetrance	J:297059
Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Rnasel^tm1Slvm/Rnasel^tm1Slvm involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	increased susceptibility to Picornaviridae infection	J:55974

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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