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Pcsk1n
Gene Detail
Symbol

Name
ID
Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
MGI:1353431
Synonyms
basic protein IA-4, MGC:19107, Pan3, proSAAS
Feature Type
protein coding gene
Genetic Map
Chromosome X
3.57 cM, cytoband A1.1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:7919822-7924410 bp, + strand
From VEGA annotation of GRCm38

  4589 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8315  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PCSK1N
Gene Tree: Pcsk1n

Human
homologs
PCSK1N, proprotein convertase subtilisin/kexin type 1 inhibitor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 27344
neXtProt AC: NX_Q9UHG2

Human Synonyms: PROSAAS, SAAS, SCG8, SgVIII

Human Chr (Location): Xp11.23; chrX:48831092-48835638 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(7) Targeted(4)
 
Mice homozygous for a null allele have behavioral/neurological defects as well as decreased body weight.
 
Interactions
Pcsk1n interacts with 182 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (235)    Tissues (150)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 32
RNA in situ 198
RT-PCR 5
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(40) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000018013 (Evidence)
Ensembl Gene Model ENSMUSG00000039278 (Evidence)
Entrez Gene 30052 (Evidence)
UniGene 4881
DFCI TC1620352, TC1578078
Consensus CDS Project CCDS29979.1
International Mouse Phenotyping Consortium Status Pcsk1n
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018013 VEGA Gene Model | MGI Sequence Detail 4589 C57BL/6J ±  kb
transcript OTTMUST00000043502 VEGA | MGI Sequence Detail 2193 Not Applicable 
polypeptide OTTMUSP00000019553 VEGA | MGI Sequence Detail 258 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(26 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010832 ProSAAS
Protein Ontology PR:000012434 ProSAAS
References
(Earliest) J:46843 Donadel G, et al., Molecular cloning and characterization of a highly basic protein, IA-4, expressed in pancreatic islets and brain. Neuroendocrinology. 1998 Mar;67(3):190-6
(Latest) J:202473 Peinado JR, et al., Blockade of islet amyloid polypeptide fibrillation and cytotoxicity by the secretory chaperones 7B2 and proSAAS. FEBS Lett. 2013 Nov 1;587(21):3406-11
All references(48)
Other
accession IDs
MGI:1306777, MGI:2147922

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory