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Sequence Detail
ID/Version
Q9QXV0 Q91W26 (UniProt | EBI) Last sequence update: 2006-10-31
Last annotation update: 2024-05-29
Sequence
description
from provider
RecName: Full=ProSAAS;AltName: Full=IA-4;AltName: Full=Proprotein convertase subtilisin/kexin type 1 inhibitor; Short=Proprotein convertase 1 inhibitor;AltName: Full=pro-SAAS;Contains: RecName: Full=KEP;Contains: RecName: Full=Big SAAS;
Provider SWISS-PROT
Sequence
Polypeptide 258 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Pcsk1n proprotein convertase subtilisin/kexin type 1 inhibitor 12 108 2 10
Sequence references in MGI J:46843 Donadel G, et al., Molecular cloning and characterization of a highly basic protein, IA-4, expressed in pancreatic islets and brain. Neuroendocrinology. 1998 Mar;67(3):190-6
J:59330 Fricker LD, et al., Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing. J Neurosci. 2000 Jan 15;20(2):639-48
J:68966 Mzhavia N, et al., ProSAAS processing in mouse brain and pituitary. J Biol Chem. 2001 Mar 2;276(9):6207-13
J:75717 Feng Y, et al., ProSAAS and prohormone convertase 1 are broadly expressed during mouse development. Brain Res Gene Expr Patterns. 2002 Jan;1(2):135-40
J:109670 Chakraborty TR, et al., Quantification of VGF- and pro-SAAS-derived peptides in endocrine tissues and the brain, and their regulation by diet and cold stress. Brain Res. 2006 May 17;1089(1):21-32
J:201131 Gomes I, et al., GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16211-16216
J:259508 Gomes I, et al., Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory