About   Help   FAQ
Plcl2 Gene Detail
Summary
  • Symbol
    Plcl2
  • Name
    phospholipase C-like 2
  • Synonyms
    mKIAA1092, Plce2, PRIP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352756
    NCBI Gene: 224860
Location & Maps
more
  • Sequence Map
    Chr17:50509547-50688493 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      178947 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 25.86 cM, cytoband C
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PLCL2, phospholipase C like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLCL2, phospholipase C like 2
    Orthology source: HomoloGene
  • Synonyms
    PLCE2
  • Links
    NCBI Gene ID: 23228
    neXtProt AC: NX_Q9UPR0

  • Chr Location
    3p24.3; chr3:16884959-17090606 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Inactivation of this gene is compatible with normal immune cell development, though the B cell response is dysregulated.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038910 Ensembl Gene Model | MGI Sequence Detail 178947 C57BL/6J ±  kb
transcript ENSMUST00000043938 Ensembl | MGI Sequence Detail 4050 Not Applicable  
polypeptide ENSMUSP00000046584 Ensembl | MGI Sequence Detail 1128 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1189 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000012841 inactive phospholipase C-like protein 2
  • InterPro Domains
    IPR000008 C2 domain
    IPR011992 EF-hand domain pair
    IPR028383 Inactive phospholipase C-like protein 2
    IPR011993 PH domain-like
    IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
    IPR001192 Phosphoinositide phospholipase C family
    IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
    IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
    IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
    IPR001849 Pleckstrin homology domain
Molecular
Reagents
less
  • All nucleic 47
    cDNA 46
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:58930 Otsuki M, et al., Identification and characterization of a new phospholipase C-like protein, PLC-L(2). Biochem Biophys Res Commun. 1999 Dec 9;266(1):97-103
  • Latest
    J:218954 Okumura T, et al., Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase. PLoS One. 2014;9(6):e100559

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory