About   Help   FAQ
Plcl2
Gene Detail
Symbol

Name
ID
Plcl2
phospholipase C-like 2
MGI:1352756
Synonyms
mKIAA1092, Plce2, PRIP-2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
25.86 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:50509547-50688493 bp, + strand
From Ensembl annotation of GRCm38

  178947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9052  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLCL2
Protein SuperFamily: inactive phospholipase C-like protein
Gene Tree: Plcl2

Human
homologs
PLCL2, phospholipase C-like 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23228
neXtProt AC: NX_Q9UPR0

Human Synonyms: PLCE2

Human Chr (Location): 3p24.3; chr3:16884959-17090606 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Inactivation of this gene is compatible with normal immune cell development, though the B cell response is dysregulated.
 
Interactions
Plcl2 interacts with 187 markers (Mir1b, Mir16-2, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plcl2    NEW 
Molecular
reagents
All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000038910 (Evidence)
Entrez Gene 224860 (Evidence)
UniGene 217362
DFCI TC1595560, TC1597578, TC1716013
DoTS DT.481609, DT.50315414, DT.91374064
NIA Mouse Gene Index U018091
Consensus CDS Project CCDS28875.1
International Mouse Phenotyping Consortium Status Plcl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038910 Ensembl Gene Model | MGI Sequence Detail 178947 C57BL/6J ±  kb
transcript ENSMUST00000043938 Ensembl | MGI Sequence Detail 4050 Not Applicable 
polypeptide ENSMUSP00000046584 Ensembl | MGI Sequence Detail 1128 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(1209 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1215)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 domain
InterPro IPR011992 EF-hand domain pair
InterPro IPR028383 Inactive phospholipase C-like protein 2
InterPro IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
InterPro IPR001192 Phosphoinositide phospholipase C family
InterPro IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Protein Ontology PR:000012841 inactive phospholipase C-like protein 2
References
(Earliest) J:58930 Otsuki M, et al., Identification and characterization of a new phospholipase C-like protein, PLC-L(2). Biochem Biophys Res Commun. 1999 Dec 9;266(1):97-103
(Latest) J:218954 Okumura T, et al., Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase. PLoS One. 2014;9(6):e100559
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory