About   Help   FAQ
Plcl2
Gene Detail
Symbol

Name
ID
Plcl2
phospholipase C-like 2
MGI:1352756
Synonyms
mKIAA1092, Plce2, PRIP-2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
25.86 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:50509547-50688493 bp, + strand
From Ensembl annotation of GRCm38

  178947 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9052  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: inactive phospholipase C-like protein
Gene Tree: Plcl2

Human
homologs
Human Homolog PLCL2, phospholipase C-like 2
NCBI Gene ID 23228
neXtProt AC  NX_Q9UPR0
Human Synonyms  PLCE2
Human Chr (Location)  3p24.3; chr3:16884959-17090606 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Inactivation of this gene is compatible with normal immune cell development, though the B cell response is dysregulated.
 
Interactions
Plcl2 interacts with 188 markers (Mir1b, Mir16-2, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) cDNA(46) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000038910 (Evidence)
Entrez Gene224860 (Evidence)
UniGene217362
DFCITC1597578, TC1595560, TC1716013
DoTSDT.50315414, DT.481609, DT.91374064
NIA Mouse Gene IndexU018091
Consensus CDS ProjectCCDS28875.1
International Mouse Knockout Project StatusPlcl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038910 Ensembl Gene Model | MGI Sequence Detail 178947 C57BL/6J ±  kb
transcript ENSMUST00000043938 Ensembl | MGI Sequence Detail 4050 Not Applicable 
polypeptide ENSMUSP00000046584 Ensembl | MGI Sequence Detail 1128 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(1209 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1215)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR011992 EF-hand-like domain
InterPro IPR001192 Phosphoinositide phospholipase C
InterPro IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012841 inactive phospholipase C-like protein 2
References
(Earliest) J:58930 Otsuki M, et al., Identification and characterization of a new phospholipase C-like protein, PLC-L(2). Biochem Biophys Res Commun. 1999 Dec 9;266(1):97-103
(Latest) J:198986 Umebayashi H, et al., Phospholipase C-related catalytically inactive protein, a novel microtubule-associated protein 1 light chain 3-binding protein, negatively regulates autophagosome formation. Biochem Biophys Res Commun. 2013 Mar 8;432(2):268-74
All references(37)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory