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Fscn1 Gene Detail
Summary
  • Symbol
    Fscn1
  • Name
    fascin actin-bundling protein 1
  • Synonyms
    Fan1, fascin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352745
    NCBI Gene: 14086
  • Alliance
    genome feature page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:142946110-142958944 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 81.84 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    419 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352745
 protein coding gene Chr5:142946098-142958944 (+)
129S1/SvImJ ENSMUSG00200040026
 protein coding gene Chr5:136816812-136829660 (+)
A/J ENSMUSG00195040850
 protein coding gene Chr5:136458451-136471365 (+)
AKR/J ENSMUSG00220020978
 protein coding gene Chr5:135694185-135707036 (+)
BALB/cJ ENSMUSG00180032409
 protein coding gene Chr5:136560510-136573421 (+)
C3H/HeJ ENSMUSG00175037883
 protein coding gene Chr5:138486064-138498963 (+)
C57BL/6NJ ENSMUSG00215040654
 protein coding gene Chr5:136394679-136407575 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027969
 protein coding gene Chr5:135695577-135709503 (+)
CAST/EiJ ENSTCUG00005026393
 protein coding gene Chr5:135840079-135853353 (+)
CBA/J ENSMUSG00210023332
 protein coding gene Chr5:137287672-137300518 (+)
DBA/2J ENSMUSG00185054464
 protein coding gene Chr5:140293555-140306403 (+)
FVB/NJ ENSMUSG00205039486
 protein coding gene Chr5:136116871-136129759 (+)
JF1/MsJ ENSUMUG00000029451
 protein coding gene Chr5:143166369-143179481 (+)
LP/J ENSMUSG00230026520
 protein coding gene Chr5:144420557-144433405 (+)
NOD/ShiLtJ ENSMUSG00190034900
 protein coding gene Chr5:136255837-136268727 (+)
NZO/HlLtJ ENSMUSG00225021772
 protein coding gene Chr5:151890101-151902988 (+)
PWK/PhJ ENSLUMG00010020348
 protein coding gene Chr5:134879910-134892946 (+)
SPRET/EiJ ENSMSPG00010025793
 protein coding gene Chr5:138492389-138505120 (+)
WSB/EiJ ENSIUOG00005029763
 protein coding gene Chr5:138778961-138791875 (+)



Homology
more
  • Human Ortholog
    FSCN1, fascin actin-bundling protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FSCN1, fascin actin-bundling protein 1
  • Synonyms
    HSN, p55, SNL
  • Links
    NCBI Gene ID: 6624
    UniProt: Q16658

  • Chr Location
    7p22.1; chr7:5592809-5606655 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele show partial neonatal lethality, smaller size, enlarged lateral ventricles, abnormal anterior commissure pars posterior morphology, impaired migration of mature dendritic cells, and hypopigmentation due to migration and cell cycle defects in melanoblasts.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    128
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    950
  • Tissues
    228
  • cDNA Data
    18
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14086 NCBI Gene Model | MGI Sequence Detail 12835 C57BL/6J ±  kb
    transcript NM_007984 RefSeq | MGI Sequence Detail 2667 ZRU/MplStud  
    polypeptide Q61553 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 18
      Primer pair 3
      Other 1
      Antibodies 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36269, MGI:107693, MGI:2140957
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 13
      Gene Ontology 18
      Phenotypes 25
    • Earliest
      J:25101 Edwards RA, et al., Cloning and expression of a murine fascin homolog from mouse brain. J Biol Chem. 1995 May 5;270(18):10764-70
    • Latest
      J:385757 Xiao Y, et al., FSCN1 induces subchondral bone sclerosis in osteoarthritis via modulating actin cytoskeleton dynamics and YAP signaling. Arthritis Res Ther. 2026 Jan 15;28(1):33
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory