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Bcar3 Gene Detail
Summary
  • Symbol
    Bcar3
  • Name
    breast cancer anti-estrogen resistance 3
  • Synonyms
    AND-34
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352501
    NCBI Gene: 29815
  • Gene Overview
    MyGene.info: BCAR3
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:122419780-122530191 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 53.41 cM, cytoband G3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3361 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352501
protein coding gene Chr3:122294136-122530191 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027839
protein coding gene Chr3:124553490-124806610 (+)
A/J MGP_AJ_G0027797
protein coding gene Chr3:120384192-120624219 (+)
AKR/J MGP_AKRJ_G0027763
protein coding gene Chr3:123449395-123694994 (+)
BALB/cJ MGP_BALBcJ_G0027809
protein coding gene Chr3:120191862-120433344 (+)
C3H/HeJ MGP_C3HHeJ_G0027540
protein coding gene Chr3:123847782-124094934 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028255
protein coding gene Chr3:129210376-129325637 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025594
protein coding gene Chr3:115809489-116050125 (+)
CAST/EiJ MGP_CASTEiJ_G0026996
protein coding gene Chr3:123232537-123489459 (+)
CBA/J MGP_CBAJ_G0027515
protein coding gene Chr3:133445506-133705293 (+)
DBA/2J MGP_DBA2J_G0027656
protein coding gene Chr3:119519875-119759148 (+)
FVB/NJ MGP_FVBNJ_G0027624
protein coding gene Chr3:117130850-117371715 (+)
LP/J MGP_LPJ_G0027766
protein coding gene Chr3:126067781-126320604 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027654
protein coding gene Chr3:141006825-141257263 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028311
protein coding gene Chr3:123006649-123258467 (+)
PWK/PhJ MGP_PWKPhJ_G0026722
protein coding gene Chr3:119220385-119468720 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0027076
protein coding gene Chr3:123734880-123985128 (+)



Homology
more
  • Human Ortholog
    BCAR3, BCAR3, NSP family adaptor protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BCAR3, BCAR3, NSP family adaptor protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AND-34, NSP2, SH2D3B
  • Links
    NCBI Gene ID: 8412
    neXtProt AC: NX_O75815
    UniProt: O75815

  • Chr Location
    1p22.1; chr1:93561741-93847150 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31181
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BCAR3
  • Gene Tree
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit cataracts due to rupture of the lens capsule and liquefaction of lens cortical fibers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 29815 NCBI Gene Model | MGI Sequence Detail 110412 C57BL/6J ±  kb
    transcript NM_013867 RefSeq | MGI Sequence Detail 3332 C57BL/6  
    polypeptide Q9QZK2 UniProt | EBI | MGI Sequence Detail 820 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000004677 breast cancer anti-estrogen resistance protein 3
    • InterPro Domains
      IPR028849 Breast cancer anti-estrogen resistance protein 3
      IPR036964 Ras guanine-nucleotide exchange factor catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR000980 SH2 domain
      IPR036860 SH2 domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 58
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139634
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:56740 Cai D, et al., AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines. J Immunol. 1999 Aug 15;163(4):2104-12
    • Latest
      J:242526 Kondo T, et al., A novel spontaneous mutation of BCAR3 results in extrusion cataracts in CF#1 mouse strain. Mamm Genome. 2016 Oct;27(9-10):451-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory