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Tpk1 Gene Detail
Summary
  • Symbol
    Tpk1
  • Name
    thiamine pyrophosphokinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352500
    NCBI Gene: 29807
  • Gene Overview
    MyGene.info: TPK1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:43345001-43666278 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 21.19 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1540 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352500
protein coding gene Chr6:43344999-43666486 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030678
protein coding gene Chr6:41980751-42312353 (-)
A/J MGP_AJ_G0030651
protein coding gene Chr6:40126659-40451396 (-)
AKR/J MGP_AKRJ_G0030576
protein coding gene Chr6:41463632-41798086 (-)
BALB/cJ MGP_BALBcJ_G0030661
protein coding gene Chr6:40414839-40740745 (-)
C3H/HeJ MGP_C3HHeJ_G0030374
protein coding gene Chr6:41468571-41806727 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031115
protein coding gene Chr6:42980434-43328015 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028322
protein coding gene Chr6:38028129-38348052 (-)
CAST/EiJ MGP_CASTEiJ_G0029778
protein coding gene Chr6:41238825-41565069 (-)
CBA/J MGP_CBAJ_G0030349
protein coding gene Chr6:44725518-45070762 (-)
DBA/2J MGP_DBA2J_G0030498
protein coding gene Chr6:39999363-40319296 (-)
FVB/NJ MGP_FVBNJ_G0030449
protein coding gene Chr6:39720625-40043953 (-)
LP/J MGP_LPJ_G0030582
protein coding gene Chr6:41967312-42301667 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030484
protein coding gene Chr6:47049596-47408962 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031145
protein coding gene Chr6:41391816-41720921 (-)
PWK/PhJ MGP_PWKPhJ_G0029490
protein coding gene Chr6:39543633-39864511 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029326
protein coding gene Chr6:40941589-41267568 (-)
WSB/EiJ MGP_WSBEiJ_G0029854
protein coding gene Chr6:41358089-41686495 (-)



Homology
more
  • Human Ortholog
    TPK1, thiamin pyrophosphokinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPK1, thiamin pyrophosphokinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HTPK1, PP20, THMD5
  • Links
    NCBI Gene ID: 27010
    neXtProt AC: NX_Q9H3S4
    UniProt: Q9H3S4

  • Chr Location
    7q35; chr7:144451941-144836424 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029735 Ensembl Gene Model | MGI Sequence Detail 321278 C57BL/6J ±  kb
transcript ENSMUST00000067888 Ensembl | MGI Sequence Detail 2671 Not Applicable  
polypeptide ENSMUSP00000065631 Ensembl | MGI Sequence Detail 243 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 40
    cDNA 39
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:58779 Nosaka K, et al., Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. J Biol Chem. 1999 Nov 26;274(48):34129-33
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory