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Tpk1
Gene Detail
 Symbol
Name
ID
Tpk1
thiamine pyrophosphokinase
MGI:1352500
Feature Type protein coding gene
Genetic Map
Chromosome 6
21.19 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:43345001-43666278 bp, - strand
From VEGA annotation of GRCm38

  321278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6960  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: thiamin pyrophosphokinase
Gene Tree: Tpk1

Human
homologs
Human Homolog TPK1, thiamin pyrophosphokinase 1
NCBI Gene ID 27010
neXtProt AC  NX_Q9H3S4
Human Synonyms  HTPK1, PP20, THMD5
Human Chr (Location)  7q34-q35; chr7:144451941-144836395 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TPK1
Alleles
and
phenotypes
All alleles(7) : Gene trapped(5) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process phosphorylation, thiamine diphosphate biosynthetic process, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (102)    Tissues (102)    Images (1)
Theiler Stages: 22, 28
Assay TypeResults
RNA in situ 94
Northern blot 8
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(39) cDNA(38) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023547 (Evidence)
Ensembl Gene ModelENSMUSG00000029735 (Evidence)
Entrez Gene29807 (Evidence)
UniGene320979
DFCITC1580156, TC1593426, TC1595778
DoTSDT.485568, DT.91356527, DT.91398383, DT.97399142
NIA Mouse Gene IndexU027252
EC2.7.6.2
PDB1IG3, 2F17
Consensus CDS ProjectCCDS39474.1
International Mouse Knockout Project StatusTpk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023547 VEGA Gene Model | MGI Sequence Detail 321278 C57BL/6J ±  kb
transcript OTTMUST00000057418 VEGA | MGI Sequence Detail 2671 Not Applicable 
polypeptide OTTMUSP00000027697 VEGA | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(8) UniProt(1)
Polymorphisms SNPs within 2kb(1545 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1549)
Protein-related
information
ResourceIDDescription
InterPro IPR006282 Thiamin pyrophosphokinase
InterPro IPR007371 Thiamin pyrophosphokinase, catalytic domain
InterPro IPR016966 Thiamin pyrophosphokinase, eukaryotic
InterPro IPR007373 Thiamin pyrophosphokinase, vitamin B1-binding domain
Protein Ontology PR:000016578 thiamin pyrophosphokinase 1
References (Earliest) J:58779 Nosaka K, et al., Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. J Biol Chem. 1999 Nov 26;274(48):34129-33
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory