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Nr2c2 Gene Detail
Summary
  • Symbol
    Nr2c2
  • Name
    nuclear receptor subfamily 2, group C, member 2
  • Synonyms
    TAK1, Tr4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352466
    NCBI Gene: 22026
Location & Maps
more
  • Sequence Map
    Chr6:92091390-92173057 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      81668 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NR2C2, nuclear receptor subfamily 2 group C member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR2C2, nuclear receptor subfamily 2 group C member 2
    Orthology source: HomoloGene
  • Synonyms
    TAK1, TR4
  • Links
    NCBI Gene ID: 7182
    neXtProt AC: NX_P49116

  • Chr Location
    3p25; chr3:14947584-15049279 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 3 alleles in 5 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    42
  • Gene trapped
    35
  • Spontaneous
    1
  • Targeted
    6
  • Genomic Mutations
    1 involving Nr2c2
  • Incidental Mutations
    APF , CvDC
Homozygous null mice display reduced body size, reduced male fertility, and impaired spermatogenesis. Mice homozygous for a conditional allele activated in the CNS exhibit increased thermal, mechanical and chemical nociception threshold, decreased pruritus and neuronal loss in the spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022788 VEGA Gene Model | MGI Sequence Detail 81668 C57BL/6J ±  kb
transcript OTTMUST00000054794 VEGA | MGI Sequence Detail 2368 Not Applicable  
polypeptide OTTMUSP00000026177 VEGA | MGI Sequence Detail 629 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    326 from dbSNP Build 137
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000011400 nuclear receptor subfamily 2 group C member 2
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 17
    cDNA 16
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-19627, MGI:102723
References
more
  • Summaries
    All 69
    Developmental Gene Expression 9
    Gene Ontology 9
    Phenotypes 30
  • Earliest
    J:22291 Hirose T, et al., TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. Mol Endocrinol. 1994 Dec;8(12):1667-80
  • Latest
    J:214809 Moniot B, et al., Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014 Sep;141(18):3561-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory