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Nr2c2 Gene Detail
Summary
  • Symbol
    Nr2c2
  • Name
    nuclear receptor subfamily 2, group C, member 2
  • Synonyms
    TAK1, Tr4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352466
    NCBI Gene: 22026
  • Gene Overview
    MyGene.info: NR2C2
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:92091418-92173058 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 41.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    305 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352466
protein coding gene Chr6:92091390-92174294 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031055
protein coding gene Chr6:93723163-93806817 (+)
A/J MGP_AJ_G0031024
protein coding gene Chr6:90154333-90238910 (+)
AKR/J MGP_AKRJ_G0030955
protein coding gene Chr6:92649833-92732834 (+)
BALB/cJ MGP_BALBcJ_G0031035
protein coding gene Chr6:90117391-90199812 (+)
C3H/HeJ MGP_C3HHeJ_G0030673
protein coding gene Chr6:91697840-91780995 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031494
protein coding gene Chr6:96142966-96221847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028661
protein coding gene Chr6:88140582-88212206 (+)
CAST/EiJ MGP_CASTEiJ_G0030142
protein coding gene Chr6:92782274-92864178 (+)
CBA/J MGP_CBAJ_G0030721
protein coding gene Chr6:99719319-99801583 (+)
DBA/2J MGP_DBA2J_G0030874
protein coding gene Chr6:89330768-89413734 (+)
FVB/NJ MGP_FVBNJ_G0030828
protein coding gene Chr6:88546222-88629876 (+)
LP/J MGP_LPJ_G0030954
protein coding gene Chr6:93676313-93758141 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030862
protein coding gene Chr6:103755758-103842277 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031521
protein coding gene Chr6:92501251-92585239 (+)
PWK/PhJ MGP_PWKPhJ_G0029858
protein coding gene Chr6:88291185-88373070 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029687
protein coding gene Chr6:91411044-91496223 (+)
WSB/EiJ MGP_WSBEiJ_G0030226
protein coding gene Chr6:92973906-93054965 (+)



Homology
more
  • Human Ortholog
    NR2C2, nuclear receptor subfamily 2 group C member 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NR2C2, nuclear receptor subfamily 2 group C member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TAK1, TR4
  • Links
    NCBI Gene ID: 7182
    neXtProt AC: NX_P49116
    UniProt: P49116

  • Chr Location
    3p25.1; chr3:14947584-15049279 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    50 phenotypes from 3 alleles in 5 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display reduced body size, reduced male fertility, and impaired spermatogenesis. Mice homozygous for a conditional allele activated in the CNS exhibit increased thermal, mechanical and chemical nociception threshold, decreased pruritus and neuronal loss in the spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22026 NCBI Gene Model | MGI Sequence Detail 81641 C57BL/6J ±  kb
    transcript NM_001347342 RefSeq | MGI Sequence Detail 7738 Not Specified  
    polypeptide P49117 UniProt | EBI | MGI Sequence Detail 596 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR001723 Nuclear hormone receptor
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
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    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-19627, MGI:102723
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 10
      Gene Ontology 9
      Phenotypes 33
    • Earliest
      J:22291 Hirose T, et al., TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. Mol Endocrinol. 1994 Dec;8(12):1667-80
    • Latest
      J:251953 Lee MP, et al., The orphan nuclear receptor TR4 regulates erythroid cell proliferation and maturation. Blood. 2017 Dec 7;130(23):2537-2547

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory