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Nr2c2
Gene Detail
Symbol

Name
ID
Nr2c2
nuclear receptor subfamily 2, group C, member 2
MGI:1352466
Synonyms
TAK1, Tr4
Feature Type
protein coding gene
Genetic Map
Chromosome 6
41.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:92091390-92173057 bp, + strand
From VEGA annotation of GRCm38

  81668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2475  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: orphan nuclear receptor TR2/TR4
Gene Tree: Nr2c2

Human
homologs
Human Homolog NR2C2, nuclear receptor subfamily 2, group C, member 2
NCBI Gene ID 7182
neXtProt AC  NX_P49116
Human Synonyms  TAK1, TR4
Human Chr (Location)  3p25; chr3:14947584-15049273 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(35) Targeted(6)
Incidental mutations (data from APF )
 
Homozygous null mice display reduced body size, reduced male fertility, and impaired spermatogenesis. Mice homozygous for a conditional allele activated in the CNS exhibit increased thermal, mechanical and chemical nociception threshold, decreased pruritus and neuronal loss in the spinal cord.
 
Interactions
Nr2c2 interacts with 463 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell differentiation, cerebellum development, ...
Component nucleoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (123)    Tissues (90)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 77
RT-PCR 46
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(16) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022788 (Evidence)
Ensembl Gene ModelENSMUSG00000005893 (Evidence)
Entrez Gene22026 (Evidence)
Consensus CDS ProjectCCDS20372.1
International Mouse Knockout Project StatusNr2c2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022788 VEGA Gene Model | MGI Sequence Detail 81668 C57BL/6J ±  kb
transcript OTTMUST00000054794 VEGA | MGI Sequence Detail 2368 Not Applicable 
polypeptide OTTMUSP00000026177 VEGA | MGI Sequence Detail 629 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(16) UniProt(11)
Polymorphisms
SNPs within 2kb(326 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000011400 nuclear receptor subfamily 2 group C member 2
References
(Earliest) J:22291 Hirose T, et al., TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. Mol Endocrinol. 1994 Dec;8(12):1667-80
(Latest) J:211571 Lin SJ, et al., TR4 nuclear receptor functions as a tumor suppressor for prostate tumorigenesis via modulation of DNA damage/repair system. Carcinogenesis. 2014 Jun;35(6):1399-406
All references(67)
Other
accession IDs
MGD-MRK-19627, MGI:102723

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory