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Magel2
Gene Detail
Symbol

Name
ID
Magel2
melanoma antigen, family L, 2
MGI:1351648
Synonyms
Mage-l2, NDNL1, nM15, ns7
Feature Type
protein coding gene
Genetic Map
Chromosome 7
34.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:62376979-62381640 bp, + strand
From NCBI annotation of GRCm38

  4662 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8460  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Magel2

Human
homologs
Human Homolog MAGEL2, MAGE-like 2
NCBI Gene ID 54551
neXtProt AC  NX_Q9UJ55
Human Synonyms  NDNL1, nM15, PWLS
Human Chr (Location)  15q11-q12; chr15:23643549-23647846 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human MAGEL2
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(3) Transgenic(1)
Genomic Mutations involving Magel2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous for a null allele that is inherited paternally exhibit some postnatal lethality, reduced male fertility, abnormal circadian rhythm, and hypoactivity. Mice heterozygous for another paternal knock-out allele exhibit 50% neonatal lethality associated with weak suckling activity.
 
Human Diseases Modeled Using Mouse Magel2 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(1)
Interactions
Magel2 interacts with 115 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (19 records)
Data Summary: Results (156)    Tissues (61)    Images (35)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 120
Northern blot 17
RT-PCR 19
cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(2) cDNA(31) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000056972 (Evidence)
Entrez Gene27385 (Evidence)
UniGene45207
DFCITC1582125, TC1597066, TC1612309
DoTSDT.102555837, DT.484930, DT.94171883
NIA Mouse Gene IndexU008171
Consensus CDS ProjectCCDS52264.1
International Mouse Knockout Project StatusMagel2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 27385 NCBI Gene Model | MGI Sequence Detail 4662 C57BL/6J ±  kb
transcript NM_013779 RefSeq | MGI Sequence Detail 4662 C57BL/6 
polypeptide Q9QZ04 UniProt | EBI | MGI Sequence Detail 490 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002190 MAGE protein
Protein Ontology PR:000010082 MAGE-like protein 2
Graphical View of Protein Domain Structure
References
(Earliest) J:58785 Boccaccio I, et al., The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region. Hum Mol Genet. 1999 Dec;8(13):2497-505
(Latest) J:198496 Resnick JL, et al., Recommendations for the investigation of animal models of Prader-Willi syndrome. Mamm Genome. 2013 Jun;24(5-6):165-78
All references(46)
Disease annotation references (2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory