Magel2
Gene Detail

Symbol Name ID

Magel2 melanoma antigen, family L, 2 MGI:1351648

Synonyms

Mage-l2, NDNL1, nM15, ns7

Feature Type

protein coding gene

Genetic Map

Chromosome 7

34.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr7:62376979-62381640 bp, + strand From NCBI annotation of GRCm38   4662 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8460  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Magel2

Human homologs

Human Homolog		MAGEL2, MAGE-like 2
NCBI Gene ID		54551
neXtProt AC		NX_Q9UJ55
Human Synonyms		NDNL1, nM15
Human Chr (Location)		15q11-q12; chr15:23888696-23892993 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAGEL2

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice heterozygous for a null allele that is inherited paternally exhibit some postnatal lethality, reduced male fertility, abnormal circadian rhythm, and hypoactivity. Mice heterozygous for another paternal knock-out allele exhibit 50% neonatal lethality associated with weak suckling activity.

 
Human Diseases Modeled Using Mouse Magel2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process	regulation of transcription, DNA-dependent
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (156)    Tissues (60)    Images (35)
Theiler Stages: 16, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	120
Northern blot	17
RT-PCR	19

cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(2) cDNA(31) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000056972 (Evidence)
Entrez Gene	27385 (Evidence)
UniGene	45207
DFCI	TC1582125, TC1597066, TC1612309
DoTS	DT.102555837, DT.484930, DT.94171883
NIA Mouse Gene Index	U008171
Consensus CDS Project	CCDS52264.1
International Mouse Knockout Project Status	Magel2

Sequences

Length	Strain/Species
genomic	27385	NCBI Gene Model | MGI Sequence Detail	4662	C57BL/6J
transcript	NM_013779	RefSeq | MGI Sequence Detail	4662	C57BL/6
polypeptide	Q9QZ04	UniProt | EBI | MGI Sequence Detail	490	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002190	MAGE protein
Protein Ontology	PR:000010082	MAGE-like protein 2

Graphical View of Protein Domain Structure

References

(Earliest) J:58785 Boccaccio I, et al., The human MAGEL2 gene and its mouse homologue are paternally expressed and mapped to the Prader-Willi region. Hum Mol Genet. 1999 Dec;8(13):2497-505
(Latest) J:174459 Boyle MP, et al., Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. J Comp Neurol. 2011 Aug 1;519(11):2061-89
All references(43)