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Srr
Gene Detail
Symbol

Name
ID
Srr
serine racemase
MGI:1351636
Synonyms
M100034, Rgsc34
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.76 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:74906509-74925948 bp, - strand
From VEGA annotation of GRCm38

  19440 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22775  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: SRR
Protein SuperFamily: threonine dehydratase/serine racemace
Gene Tree: Srr

Human
homologs
SRR, serine racemase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 63826
neXtProt AC: NX_Q9GZT4

Human Synonyms: ILV1, ISO1

Human Chr (Location): 17p13; chr17:2303371-2325264 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Chemically induced (ENU)(2) Gene trapped(12) Targeted(5)
Genomic Mutations involving Srr (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit decreased D-serine levels in the cerebral cortex and hippocampus, and neuronal damage associated with NMDA excitotoxicity and beta-amyloid peptide 1-42 exposure is decreased.
 
Human Diseases Modeled in Mice Using Srr (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Srr interacts with 236 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process brain development, cellular amino acid metabolic process, ...
Component apical part of cell, cytoplasm, ...
Function ATP binding, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (108)    Tissues (100)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Western blot 14
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase srr    NEW 
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000006189 (Evidence)
Ensembl Gene Model ENSMUSG00000001323 (Evidence)
Entrez Gene 27364 (Evidence)
EC 5.1.1.18, 4.3.1.18, 4.3.1.17
Consensus CDS Project CCDS25038.1
International Mouse Phenotyping Consortium Status Srr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006189 VEGA Gene Model | MGI Sequence Detail 19440 C57BL/6J ±  kb
transcript OTTMUST00000013949 VEGA | MGI Sequence Detail 3239 Not Applicable 
polypeptide OTTMUSP00000006479 VEGA | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site
InterPro IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily
Protein Ontology PR:000015636 serine racemase
References
(Earliest) J:58521 Wolosker H, et al., Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13409-14
(Latest) J:218910 Le Bail M, et al., Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E204-13
All references(64)
Disease annotation references (2)
Other
accession IDs
MGI:3798494

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory