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Srr
Gene Detail
 Symbol
Name
ID
Srr
serine racemase
MGI:1351636
Feature Type protein coding gene
Genetic Map
Chromosome 11
45.76 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:74906509-74925948 bp, - strand
From VEGA annotation of GRCm38

  19440 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22775  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: threonine dehydratase/serine racemace
Gene Tree: Srr

Human
homologs
Human Homolog SRR, serine racemase
NCBI Gene ID 63826
neXtProt AC  NX_Q9GZT4
Human Synonyms  ILV1, ISO1
Human Chr (Location)  17p13; chr17:2303371-2325259 (+)  GRCh38
Alleles
and
phenotypes
All alleles(17) : Targeted(4) Gene trapped(12) Chemically induced(1)
 
Mice homozygous for a null allele exhibit decreased D-serine levels in the cerebral cortex and hippocampus, and neuronal damage associated with NMDA excitotoxicity and beta-amyloid peptide 1-42 exposure is decreased.
 
Human Diseases Modeled Using Mouse Srr (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process cellular amino acid metabolic process, D-serine biosynthetic process, ...
Component apical part of cell, cytoplasm, ...
Function ATP binding, calcium ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (108)    Tissues (99)    Images (2)
Theiler Stages: 20, 22, 25, 26, 28
Assay TypeResults
RNA in situ 94
Western blot 14
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) cDNA(23)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000006189 (Evidence)
Ensembl Gene ModelENSMUSG00000001323 (Evidence)
Entrez Gene27364 (Evidence)
EC4.3.1.17, 4.3.1.18, 5.1.1.18
Consensus CDS ProjectCCDS25038.1
International Mouse Knockout Project StatusSrr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006189 VEGA Gene Model | MGI Sequence Detail 19440 C57BL/6J ±  kb
transcript OTTMUST00000013949 VEGA | MGI Sequence Detail 3239 Not Applicable 
polypeptide OTTMUSP00000006479 VEGA | MGI Sequence Detail 339 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000634 Serine/threonine dehydratase, pyridoxal-phosphate-binding site
InterPro IPR001926 Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily
Protein Ontology PR:000015636 serine racemase
References (Earliest) J:58521 Wolosker H, et al., Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13409-14
(Latest) J:199792 Ehmsen JT, et al., D-Serine in Glia and Neurons Derives from 3-Phosphoglycerate Dehydrogenase. J Neurosci. 2013 Jul 24;33(30):12464-12469
All references(61)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory