Srr
Gene Detail

Symbol Name ID

Srr serine racemase MGI:1351636

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.76 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:74906509-74925948 bp, - strand From VEGA annotation of GRCm38   19440 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22775  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: threonine dehydratase/serine racemace
Gene Tree: Srr

Human homologs

Human Homolog		SRR, serine racemase
NCBI Gene ID		63826
neXtProt AC		NX_Q9GZT4
Human Synonyms		ILV1, ISO1
Human Chr (Location)		17p13; chr17:2207248-2228553 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(17) : Targeted(4) Gene trapped(12) Chemically induced(1)
 

Mice homozygous for a null allele exhibit decreased D-serine levels in the cerebral cortex and hippocampus, and neuronal damage associated with NMDA excitotoxicity and beta-amyloid peptide 1-42 exposure is decreased.

 
Human Diseases Modeled Using Mouse Srr (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	cellular amino acid metabolic process, D-serine biosynthetic process, ...
Component	apical part of cell, cytoplasm, ...
Function	ATP binding, calcium ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (108)    Tissues (99)    Images (2)
Theiler Stages: 20, 22, 25, 26, 28

Assay Type	Results
RNA in situ	94
Western blot	14

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(23)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000006189 (Evidence)
Ensembl Gene Model	ENSMUSG00000001323 (Evidence)
Entrez Gene	27364 (Evidence)
EC	4.3.1.17, 4.3.1.18, 5.1.1.18
Consensus CDS Project	CCDS25038.1
International Mouse Knockout Project Status	Srr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006189	VEGA Gene Model | MGI Sequence Detail	19440	C57BL/6J
transcript	OTTMUST00000013949	VEGA | MGI Sequence Detail	3239	Not Applicable
polypeptide	OTTMUSP00000006479	VEGA | MGI Sequence Detail	339	Not Applicable

All sequences(74) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(51 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000634	Serine/threonine dehydratase, pyridoxal-phosphate-binding site
InterPro	IPR001926	Tryptophan synthase beta subunit-like PLP-dependent enzymes superfamily
Protein Ontology	PR:000015636	serine racemase

References

(Earliest) J:58521 Wolosker H, et al., Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13409-14
(Latest) J:194537 Stobart JL, et al., Astrocyte-induced cortical vasodilation is mediated by D-serine and endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3149-54
All references(59)