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Dguok
Gene Detail
 Symbol
Name
ID
Dguok
deoxyguanosine kinase
MGI:1351602
Synonyms dGK
Feature Type protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:83480217-83506969 bp, - strand
From VEGA annotation of GRCm38

  26753 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8456  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: deoxynucleoside kinase
Gene Tree: Dguok

Human
homologs
Human Homolog DGUOK, deoxyguanosine kinase
NCBI Gene ID 1716
neXtProt AC  NX_Q16854
Human Synonyms  dGK, MTDPS3
Human Chr (Location)  2p13; chr2:73926826-73958961 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DGUOK
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(4)
Incidental mutations (data from APF )
Interactions
Dguok interacts with 26 markers (Mir18, Mir18b, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process deoxyribonucleoside monophosphate biosynthetic process, dGTP metabolic process, ...
Component cytoplasm, cytosol, ...
Function ATP binding, deoxyguanosine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (137)    Tissues (123)    Images (13)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 137
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) cDNA(43)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022810 (Evidence)
Ensembl Gene ModelENSMUSG00000014554 (Evidence)
Entrez Gene27369 (Evidence)
UniGene42234
DFCITC1580365, TC1588479, TC1620318, TC1776334
DoTSDT.101364346, DT.101376091, DT.103564228, DT.110489004, DT.91339830, DT.94250829, DT.97414648
NIA Mouse Gene IndexU027529, U027530
EC2.7.1.113
Consensus CDS ProjectCCDS20279.1, CCDS51821.1
International Mouse Knockout Project StatusDguok
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022810 VEGA Gene Model | MGI Sequence Detail 26753 C57BL/6J ±  kb
transcript OTTMUST00000054823 VEGA | MGI Sequence Detail 1107 Not Applicable 
polypeptide OTTMUSP00000026193 VEGA | MGI Sequence Detail 277 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(9) UniProt(5)
Polymorphisms SNPs within 2kb(201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002624 Deoxynucleoside kinase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006452 deoxyguanosine kinase, mitochondrial
References (Earliest) J:491 Jenuth JP, et al., Absence of dGTP accumulation and compensatory loss of deoxyguanosine kinase in purine nucleoside phosphorylase deficient mice. Adv Exp Med Biol. 1991;309B:273-6
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory