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Dguok Gene Detail
Summary
  • Symbol
    Dguok
  • Name
    deoxyguanosine kinase
  • Synonyms
    dGK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351602
    NCBI Gene: 27369
  • Gene Overview
    MyGene.info: DGUOK
Location & Maps
more
  • Sequence Map
    Chr6:83480217-83506969 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26753 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DGUOK, deoxyguanosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DGUOK, deoxyguanosine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    dGK, MTDPS3
  • Links
    NCBI Gene ID: 1716
    neXtProt AC: NX_Q16854

  • Chr Location
    2p13; chr2:73926826-73958961 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human DGUOK associations

Human Disease Mouse Models
       Mitochondrial DNA Depletion Syndrome 3 (hepatocerebral Type); MTDPS3   OMIM: 251880
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    4
  • Spontaneous
    1
  • Genomic Mutations
    1 involving Dguok
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022810 VEGA Gene Model | MGI Sequence Detail 26753 C57BL/6J ±  kb
transcript OTTMUST00000054823 VEGA | MGI Sequence Detail 1107 Not Applicable  
polypeptide OTTMUSP00000026193 VEGA | MGI Sequence Detail 277 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    201 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000006452 deoxyguanosine kinase, mitochondrial
  • EC
  • InterPro Domains
    IPR002624 Deoxynucleoside kinase
    IPR031314 Deoxynucleoside kinase domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 43
    cDNA 43

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 5
  • Earliest
    J:491 Jenuth JP, et al., Absence of dGTP accumulation and compensatory loss of deoxyguanosine kinase in purine nucleoside phosphorylase deficient mice. Adv Exp Med Biol. 1991;309B:273-6
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory