Dguok
Gene Detail

Symbol Name ID

Dguok deoxyguanosine kinase MGI:1351602

Synonyms

dGK

Feature Type

protein coding gene

Genetic Map

Chromosome 6

35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:83480217-83506969 bp, - strand From VEGA annotation of GRCm38   26753 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8456  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: deoxynucleoside kinase
Gene Tree: Dguok

Human homologs

Human Homolog		DGUOK, deoxyguanosine kinase
NCBI Gene ID		1716
neXtProt AC		NX_Q16854
Human Synonyms		dGK, MTDPS3
Human Chr (Location)		2p13; chr2:74153953-74186088 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DGUOK

Alleles and phenotypes

All alleles(4) : Gene trapped(4)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	dGTP metabolic process, negative regulation of neuron projection development, ...
Component	cytoplasm, cytosol, ...
Function	ATP binding, deoxyguanosine kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (137)    Tissues (123)    Images (13)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	137

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) cDNA(44)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022810 (Evidence)
Ensembl Gene Model	ENSMUSG00000014554 (Evidence)
Entrez Gene	27369 (Evidence)
UniGene	42234
DFCI	TC1580365, TC1588479, TC1620318, TC1776334
DoTS	DT.101364346, DT.101376091, DT.103564228, DT.110489004, DT.91339830, DT.94250829, DT.97414648
NIA Mouse Gene Index	U027529, U027530
EC	2.7.1.113
Consensus CDS Project	CCDS20279.1, CCDS51821.1
International Mouse Knockout Project Status	Dguok

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022810	VEGA Gene Model | MGI Sequence Detail	26753	C57BL/6J
transcript	OTTMUST00000054823	VEGA | MGI Sequence Detail	1107	Not Applicable
polypeptide	OTTMUSP00000026193	VEGA | MGI Sequence Detail	277	Not Applicable

All sequences(56) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(186 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002624	Deoxynucleoside kinase
Protein Ontology	PR:000006452	deoxyguanosine kinase, mitochondrial

References

(Earliest) J:491 Jenuth JP, et al., Absence of dGTP accumulation and compensatory loss of deoxyguanosine kinase in purine nucleoside phosphorylase deficient mice. Adv Exp Med Biol. 1991;309B:273-6
(Latest) J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23
All references(36)