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Sh2d2a Gene Detail
Summary
  • Symbol
    Sh2d2a
  • Name
    SH2 domain containing 2A
  • Synonyms
    Lad, Lck-associated adapter protein, RIBP, Rlk/Itk-binding protein, TSAd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351596
    NCBI Gene: 27371
  • Gene Overview
    MyGene.info: SH2D2A
Location & Maps
more
  • Sequence Map
    Chr3:87846755-87855722 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8968 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    SH2D2A, SH2 domain containing 2A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SH2D2A, SH2 domain containing 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    F2771, SCAP, TSAD, VRAP
  • Links
    NCBI Gene ID: 9047
    neXtProt AC: NX_Q9NP31

  • Chr Location
    1q21; chr1:156806243-156816862 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Sh2d2a
  • Incidental Mutations
While T cell development is normal, T cell proliferation in response to TCR-mediated activation is impaired in homozygous null mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000051868 VEGA Gene Model | MGI Sequence Detail 8968 C57BL/6J ±  kb
transcript OTTMUST00000130612 VEGA | MGI Sequence Detail 1807 Not Applicable  
polypeptide OTTMUSP00000069978 VEGA | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014814 SH2 domain-containing protein 2A
  • InterPro Domains
    IPR000980 SH2 domain
Molecular
Reagents
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  • All nucleic 15
    Genomic 1
    cDNA 13
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:58458 Choi YB, et al., Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. J Immunol. 1999 Nov 15;163(10):5242-9
  • Latest
    J:230680 Massena S, et al., Identification and characterization of VEGF-A-responsive neutrophils expressing CD49d, VEGFR1, and CXCR4 in mice and humans. Blood. 2015 Oct 22;126(17):2016-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory