About   Help   FAQ
Sh2d2a Gene Detail
Summary
  • Symbol
    Sh2d2a
  • Name
    SH2 domain containing 2A
  • Synonyms
    Lad, Lck-associated adapter protein, RIBP, Rlk/Itk-binding protein, TSAd
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351596
    NCBI Gene: 27371
  • Gene Overview
    MyGene.info: SH2D2A
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:87846755-87855722 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.78 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351596
protein coding gene Chr3:87846755-87855722 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027370
protein coding gene Chr3:87973472-87982429 (+)
A/J MGP_AJ_G0027334
protein coding gene Chr3:84986844-84995842 (+)
AKR/J MGP_AKRJ_G0027300
protein coding gene Chr3:87067739-87076709 (+)
BALB/cJ MGP_BALBcJ_G0027343
protein coding gene Chr3:85084235-85093205 (+)
C3H/HeJ MGP_C3HHeJ_G0027086
protein coding gene Chr3:87339734-87348696 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027789
protein coding gene Chr3:91207416-91216371 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025142
protein coding gene Chr3:80609936-80619011 (+)
CAST/EiJ MGP_CASTEiJ_G0026533
protein coding gene Chr3:87555846-87564806 (+)
CBA/J MGP_CBAJ_G0027061
protein coding gene Chr3:94288157-94297155 (+)
DBA/2J MGP_DBA2J_G0027197
protein coding gene Chr3:84480455-84489425 (+)
FVB/NJ MGP_FVBNJ_G0027166
protein coding gene Chr3:82750943-82760836 (+)
LP/J MGP_LPJ_G0027305
protein coding gene Chr3:88934324-88943273 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027185
protein coding gene Chr3:100551823-100560839 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027847
protein coding gene Chr3:86823863-86832906 (+)
PWK/PhJ MGP_PWKPhJ_G0026266
protein coding gene Chr3:84275124-84284071 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026083
protein coding gene Chr3:86013844-86022682 (+)
WSB/EiJ MGP_WSBEiJ_G0026612
protein coding gene Chr3:87184586-87193543 (+)



Homology
more
  • Human Ortholog
    SH2D2A, SH2 domain containing 2A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SH2D2A, SH2 domain containing 2A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    F2771, SCAP, TSAD, VRAP
  • Links
    NCBI Gene ID: 9047
    neXtProt AC: NX_Q9NP31
    UniProt: Q9NP31

  • Chr Location
    1q23.1; chr1:156806238-156816853 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
While T cell development is normal, T cell proliferation in response to TCR-mediated activation is impaired in homozygous null mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 27371 NCBI Gene Model | MGI Sequence Detail 8968 C57BL/6J ±  kb
transcript NM_021309 RefSeq | MGI Sequence Detail 4758 C57BL/6  
polypeptide Q9QXK9 UniProt | EBI | MGI Sequence Detail 374 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 14
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Diseases 1
    Gene Ontology 5
    Phenotypes 17
  • Earliest
    J:58458 Choi YB, et al., Lad, an adapter protein interacting with the SH2 domain of p56lck, is required for T cell activation. J Immunol. 1999 Nov 15;163(10):5242-9
  • Latest
    J:259509 Gordon EJ, et al., The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Sci Signal. 2016 Jul 19;9(437):ra72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/11/2018
MGI 6.13
The Jackson Laboratory