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Clnk Gene Detail
Summary
  • Symbol
    Clnk
  • Name
    cytokine-dependent hematopoietic cell linker
  • Synonyms
    MIST
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351468
    NCBI Gene: 27278
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:38706462-38876812 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 20.81 cM
  • Mapping Data
    2 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    1445 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351468
protein coding gene Chr5:38705588-38876858 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029515
protein coding gene Chr5:37141054-37318586 (-)
A/J MGP_AJ_G0029481
protein coding gene Chr5:35883001-36053871 (-)
AKR/J MGP_AKRJ_G0029431
protein coding gene Chr5:37230744-37403849 (-)
BALB/cJ MGP_BALBcJ_G0029492
protein coding gene Chr5:36374576-36541092 (-)
C3H/HeJ MGP_C3HHeJ_G0029215
protein coding gene Chr5:37220709-37399731 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029946
protein coding gene Chr5:39096477-39268255 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027184
protein coding gene Chr5:33549975-33717835 (-)
CAST/EiJ MGP_CASTEiJ_G0028623
protein coding gene Chr5:36403069-36582929 (-)
CBA/J MGP_CBAJ_G0029182
protein coding gene Chr5:40009829-40188506 (-)
DBA/2J MGP_DBA2J_G0029329
protein coding gene Chr5:36012369-36186315 (-)
FVB/NJ MGP_FVBNJ_G0029288
protein coding gene Chr5:35510228-35672901 (-)
LP/J MGP_LPJ_G0029415
protein coding gene Chr5:37593536-37777493 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029318
protein coding gene Chr5:40734516-40918814 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029979
protein coding gene Chr5:36734105-36901904 (-)
PWK/PhJ MGP_PWKPhJ_G0028347
protein coding gene Chr5:35185389-35356880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028181
protein coding gene Chr5:36182325-36361616 (-)
WSB/EiJ MGP_WSBEiJ_G0028704
protein coding gene Chr5:36810999-36991853 (-)



Homology
more
  • Human Ortholog
    CLNK, cytokine dependent hematopoietic cell linker
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CLNK, cytokine dependent hematopoietic cell linker
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MIST
  • Links
    NCBI Gene ID: 116449
    neXtProt AC: NX_Q7Z7G1
    UniProt: Q7Z7G1

  • Chr Location
    4p16.1; chr4:10489899-10734853 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    6 involving Clnk
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for a reporter allele display altered natural killer (NK) T cell physiology and enhanced NK cell cytolysis. Mice homozygous for knock-out allele display abnormal mast cell physiology as well as enhanced NK cell cytolysis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039315 Ensembl Gene Model | MGI Sequence Detail 170351 C57BL/6J ±  kb
transcript ENSMUST00000169819 Ensembl | MGI Sequence Detail 1700 Not Applicable  
polypeptide ENSMUSP00000128473 Ensembl | MGI Sequence Detail 435 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
References
more
  • Summaries
    All 40
    Diseases 1
    Gene Ontology 5
    Phenotypes 22
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory