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Grm6
Gene Detail
 Symbol
Name
ID
Grm6
glutamate receptor, metabotropic 6
MGI:1351343
Synonyms mGluR6, nerg1, nob2, nob3
Feature Type protein coding gene
Genetic Map
Chromosome 11
30.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:50850685-50866208 bp, + strand
From VEGA annotation of GRCm38

  15524 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20232  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm6

Human
homologs
Human Homolog GRM6, glutamate receptor, metabotropic 6
NCBI Gene ID 2916
neXtProt AC  NX_O15303
Human Synonyms  CSNB1B, GPRC1F, mGlu6, MGLUR6
Human Chr (Location)  5q35; chr5:178978327-178995123 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRM6
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show loss of ON responses without significant alteration of OFF responses in visual transmission or changes in visual behavioral responses. ENU-induced mutant mice have an ERG that lacks the rod b-wave and scotopic threshold response, while the cone ERG is of large amplitude.
 
Interactions
Grm6 interacts with 163 markers (Mir7-1, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway, detection of light stimulus involved in visual perception, ...
Component cell projection, endoplasmic reticulum, ...
Function adenylate cyclase inhibiting G-protein coupled glutamate receptor activity, glutamate receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 28
Assay TypeResults
RT-PCR 1
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(1) cDNA(14) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000007883 (Evidence)
Ensembl Gene ModelENSMUSG00000000617 (Evidence)
Entrez Gene108072 (Evidence)
UniGene134265
DFCITC1587321, TC1714315
DoTSDT.101723015, DT.40140203, DT.91425192
NIA Mouse Gene IndexU012556
Consensus CDS ProjectCCDS48785.1
International Mouse Knockout Project StatusGrm6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007883 VEGA Gene Model | MGI Sequence Detail 15524 C57BL/6J ±  kb
transcript OTTMUST00000017928 VEGA | MGI Sequence Detail 4291 Not Applicable 
polypeptide OTTMUSP00000008240 VEGA | MGI Sequence Detail 871 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR000112 GPCR, family 3, metabotropic glutamate receptor 6
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000008268 metabotropic glutamate receptor 6
References (Earliest) J:48532 Masu M, et al., Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell. 1995 Mar 10;80(5):757-65
(Latest) J:211063 Ray TA, et al., GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells. J Neurosci. 2014 Apr 30;34(18):6334-43
All references(59)
Other
accession IDs
MGD-MRK-10269, MGI:2684849, MGI:3605830, MGI:3605838, MGI:95830

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory