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Grm6 Gene Detail
Summary
  • Symbol
    Grm6
  • Name
    glutamate receptor, metabotropic 6
  • Synonyms
    mGluR6, nerg1, nob3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351343
    NCBI Gene: 108072
Location & Maps
more
  • Sequence Map
    Chr11:50850685-50866208 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15524 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 30.93 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GRM6, glutamate metabotropic receptor 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GRM6, glutamate metabotropic receptor 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CSNB1B, GPRC1F, mGlu6, MGLUR6
  • Links
    NCBI Gene ID: 2916
    neXtProt AC: NX_O15303

  • Chr Location
    5q35.3; chr5:178978327-178995123 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Grm6 mouse models; 1 with human GRM6 associations

Human Disease Mouse Models
       Night Blindness, Congenital Stationary, Type 1B; CSNB1B   OMIM: 257270 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 5 alleles in 9 genetic backgrounds
    1 phenotype from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Spontaneous
    2
  • Targeted
    5
  • Genomic Mutations
    1 involving Grm6
  • Incidental Mutations
Homozygous null mice show loss of ON responses without significant alteration of OFF responses in visual transmission or changes in visual behavioral responses. ENU-induced mutant mice have an ERG that lacks the rod b-wave and scotopic threshold response, while the cone ERG is of large amplitude.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007883 VEGA Gene Model | MGI Sequence Detail 15524 C57BL/6J ±  kb
transcript OTTMUST00000017928 VEGA | MGI Sequence Detail 4291 Not Applicable  
polypeptide OTTMUSP00000008240 VEGA | MGI Sequence Detail 871 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    24 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 14
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-10269, MGI:2684849, MGI:3605830, MGI:3605838, MGI:95830
References
more
  • Summaries
    All 64
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 10
    Phenotypes 33
  • Earliest
    J:48532 Masu M, et al., Specific deficit of the ON response in visual transmission by targeted disruption of the mGluR6 gene. Cell. 1995 Mar 10;80(5):757-65
  • Latest
    J:230778 Chakraborty R, et al., ON pathway mutations increase susceptibility to form-deprivation myopia. Exp Eye Res. 2015 Aug;137:79-83

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory