Grm6^em#Mrho
Endonuclease-mediated Allele Detail

Summary

• Symbol: Grm6^em#Mrho
• Name: glutamate receptor, metabotropic 6; endonuclease-mediated mutation, Mrinalini Hoon
• MGI ID: MGI:8272179
• Gene: Grm6 Location: Chr11:50741512-50757035 bp, + strand Genetic Position: Chr11, 30.93 cM
• Alliance: Grm6^em#Mrho page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology introduced nonsense mutations at the N-terminal which are predicted to generate truncated proteins and nonsense-mediated decay of mRNA. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:371980)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grm6 Mutation: 52 strains or lines available

References

• Original: J:371980 Khoussine J, et al., Divergent mechanisms of neural adaptation and instability in the mammalian retina. Curr Biol. 2025 Jul 21;35(14):3381-3395.e4
• All: 1 reference(s)