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Grm5 Gene Detail
Summary
  • Symbol
    Grm5
  • Name
    glutamate receptor, metabotropic 5
  • Synonyms
    6430542K11Rik, Glu5R, Gprc1e, mGluR5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351342
    NCBI Gene: 108071
Location & Maps
more
  • Sequence Map
    Chr7:87584168-88134907 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      550740 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 49.01 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GRM5, glutamate metabotropic receptor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRM5, glutamate metabotropic receptor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GPRC1E, mGlu5, MGLUR5, PPP1R86
  • Links
    NCBI Gene ID: 2915
    neXtProt AC: NX_P41594

  • Chr Location
    11q14.2-q14.3; chr11:88504576-89065961 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Radiation induced
    3
  • Targeted
    6
  • Genomic Mutations
    4 involving Grm5
  • Incidental Mutations
Homozygous null mice have reduced corticostriatal long term potentiation, do not exhibit hyperactivity after cocaine consumption and do not self-administer cocaine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016489 VEGA Gene Model | MGI Sequence Detail 550740 C57BL/6J ±  kb
transcript OTTMUST00000039788 VEGA | MGI Sequence Detail 4500 Not Applicable  
polypeptide OTTMUSP00000022659 VEGA | MGI Sequence Detail 1203 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2185 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 1
    cDNA 6

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10268, MGI:2142054, MGI:95829
References
more
  • Summaries
    All 111
    Developmental Gene Expression 7
    Gene Ontology 11
    Phenotypes 71
  • Earliest
    J:36610 Winder DG, et al., Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication. J Neurosci Res. 1996 Oct 15;46(2):131-7
  • Latest
    J:231610 Guo W, et al., Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice. J Neurosci. 2016 Feb 17;36(7):2131-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory