About   Help   FAQ
Grm5
Gene Detail
 Symbol
Name
ID
Grm5
glutamate receptor, metabotropic 5
MGI:1351342
Synonyms 6430542K11Rik, Glu5R, Gprc1e, mGluR5
Feature Type protein coding gene
Genetic Map
Chromosome 7
49.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:87803815-88134907 bp, + strand
From VEGA annotation of GRCm38

  331093 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37354  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm5

Human
homologs
Human Homolog GRM5, glutamate receptor, metabotropic 5
NCBI Gene ID 2915
neXtProt AC  NX_P41594
Human Synonyms  GPRC1E, mGlu5, MGLUR5, PPP1R86
Human Chr (Location)  11q14.3; chr11:88504088-89113519 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice have reduced corticostriatal long term potentiation, do not exhibit hyperactivity after cocaine consumption and do not self-administer cocaine.
 
Interactions
Grm5 interacts with 458 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process activation of MAPKKK activity, cognition, ...
Component astrocyte projection, cytoplasm, ...
Function A2A adenosine receptor binding, glutamate receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (117)    Tissues (48)    Images (35)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 117
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) Genomic(1) cDNA(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016489 (Evidence)
Ensembl Gene ModelENSMUSG00000049583 (Evidence)
Entrez Gene108071 (Evidence)
DFCITC1602836, TC1603175, TC1609158
DoTSDT.111013332, DT.55137760, DT.87039005, DT.97371859, DT.97385902
Consensus CDS ProjectCCDS40013.1, CCDS52305.1
International Mouse Knockout Project StatusGrm5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016489 VEGA Gene Model | MGI Sequence Detail 331093 C57BL/6J ±  kb
transcript OTTMUST00000039788 VEGA | MGI Sequence Detail 3739 Not Applicable 
polypeptide OTTMUSP00000022659 VEGA | MGI Sequence Detail 984 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(11) UniProt(10)
Polymorphisms SNPs within 2kb(2216 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR000202 GPCR, family 3, metabotropic glutamate receptor 5
InterPro IPR011500 GPCR, family 3, nine cysteines domain
InterPro IPR019588 Metabotropic glutamate receptor, Homer-binding domain
Protein Ontology PR:000008267 metabotropic glutamate receptor 5
References (Earliest) J:36610 Winder DG, et al., Roles of metabotropic glutamate receptors in glial function and glial-neuronal communication. J Neurosci Res. 1996 Oct 15;46(2):131-7
(Latest) J:207093 Ribeiro FM, et al., Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease. Hum Mol Genet. 2014 Apr 15;23(8):2030-42
All references(103)
Other
accession IDs
MGD-MRK-10268, MGI:2142054, MGI:95829

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory