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Grm3 Gene Detail
Summary
  • Symbol
    Grm3
  • Name
    glutamate receptor, metabotropic 3
  • Synonyms
    0710001G23Rik, Gprc1c, mGlu3, mGluR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351340
    NCBI Gene: 108069
Location & Maps
more
  • Sequence Map
    Chr5:9485541-9725170 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      239630 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 3.69 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    GRM3, glutamate metabotropic receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRM3, glutamate metabotropic receptor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUR3, GPRC1C, mGlu3, MGLUR3
  • Links
    NCBI Gene ID: 2913
    neXtProt AC: NX_Q14832

  • Chr Location
    7q21.11-q21.12; chr7:86643914-86864879 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054376 VEGA Gene Model | MGI Sequence Detail 239630 C57BL/6J ±  kb
transcript OTTMUST00000134901 VEGA | MGI Sequence Detail 3049 Not Applicable  
polypeptide OTTMUSP00000071496 VEGA | MGI Sequence Detail 879 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2359 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 11
    cDNA 9
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10266, MGI:1917596, MGI:95827
References
more
  • Summaries
    All 60
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:21416 Chavis P, et al., The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J Neurosci. 1994 Nov;14(11 Pt 2):7067-76
  • Latest
    J:233703 Schmitz SK, et al., Presynaptic inhibition upon CB1 or mGlu2/3 receptor activation requires ERK/MAPK phosphorylation of Munc18-1. EMBO J. 2016 Jun 1;35(11):1236-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory