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Grm3
Gene Detail
 Symbol
Name
ID
Grm3
glutamate receptor, metabotropic 3
MGI:1351340
Synonyms 0710001G23Rik, Gprc1c, mGlu3, mGluR3
Feature Type protein coding gene
Genetic Map
Chromosome 5
3.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:9485236-9725352 bp, - strand
From NCBI annotation of GRCm38

  240117 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:651  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm3

Human
homologs
Human Homolog GRM3, glutamate receptor, metabotropic 3
NCBI Gene ID 2913
neXtProt AC  NX_Q14832
Human Synonyms  GLUR3, GPRC1C, mGlu3, MGLUR3
Human Chr (Location)  7q21.1-q21.2; chr7:86643914-86864876 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection.
 
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component astrocyte projection, axon, ...
Function calcium channel regulator activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (344)    Tissues (217)    Images (53)
Theiler Stages: 19, 22, 23, 26, 28
Assay TypeResults
RNA in situ 256
In situ reporter (knock in) 50
RT-PCR 38
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000003974 (Evidence)
Entrez Gene108069 (Evidence)
UniGene318966
DFCITC1585730, TC1604806
DoTSDT.60103829
NIA Mouse Gene IndexU005239
Consensus CDS ProjectCCDS19090.1
International Mouse Knockout Project StatusGrm3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 108069 NCBI Gene Model | MGI Sequence Detail 240117 C57BL/6J ±  kb
transcript NM_181850 RefSeq | MGI Sequence Detail 3536 C57BL/6 
polypeptide Q9QYS2 UniProt | EBI | MGI Sequence Detail 879 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(2368 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR001234 GPCR, family 3, metabotropic glutamate receptor 3
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000008265 metabotropic glutamate receptor 3
Graphical View of Protein Domain Structure
References (Earliest) J:21416 Chavis P, et al., The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J Neurosci. 1994 Nov;14(11 Pt 2):7067-76
(Latest) J:202321 Lane TA, et al., Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice. BMC Neurosci. 2013;14:102
All references(57)
Other
accession IDs
MGD-MRK-10266, MGI:1917596, MGI:95827

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory