Grm3
Gene Detail

Symbol Name ID

Grm3 glutamate receptor, metabotropic 3 MGI:1351340

Synonyms

0710001G23Rik, Gprc1c, mGlu3, mGluR3

Feature Type

protein coding gene

Genetic Map

Chromosome 5

3.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr5:9485236-9725352 bp, - strand From NCBI annotation of GRCm38   240117 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:651  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm3

Human homologs

Human Homolog		GRM3, glutamate receptor, metabotropic 3
NCBI Gene ID		2913
neXtProt AC		NX_Q14832
Human Synonyms		GLUR3, GPRC1C, mGlu3, MGLUR3
Human Chr (Location)		7q21.1-q21.2; chr7:86273230-86494192 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway, G-protein coupled receptor signaling pathway, ...
Component	astrocyte projection, axon, ...
Function	calcium channel regulator activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (295)    Tissues (168)    Images (51)
Theiler Stages: 19, 22, 23, 28

Assay Type	Results
RNA in situ	207
In situ reporter (knock in)	50
RT-PCR	38

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000003974 (Evidence)
Entrez Gene	108069 (Evidence)
UniGene	318966
DFCI	TC1585730, TC1604806
DoTS	DT.60103829
NIA Mouse Gene Index	U005239
Consensus CDS Project	CCDS19090.1
International Mouse Knockout Project Status	Grm3

Sequences

Length	Strain/Species
genomic	108069	NCBI Gene Model | MGI Sequence Detail	240117	C57BL/6J
transcript	NM_181850	RefSeq | MGI Sequence Detail	3536	C57BL/6
polypeptide	Q9QYS2	UniProt | EBI | MGI Sequence Detail	879	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(1302 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000337	GPCR, family 3
InterPro	IPR017979	GPCR, family 3, conserved site
InterPro	IPR017978	GPCR, family 3, C-terminal
InterPro	IPR000162	GPCR, family 3, metabotropic glutamate receptor
InterPro	IPR001234	GPCR, family 3, metabotropic glutamate receptor 3
InterPro	IPR011500	GPCR, family 3, nine cysteines domain
Protein Ontology	PR:000008265	metabotropic glutamate receptor 3

Graphical View of Protein Domain Structure

References

(Earliest) J:21416 Chavis P, et al., The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J Neurosci. 1994 Nov;14(11 Pt 2):7067-76
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(52)

Other accession IDs

MGD-MRK-10266, MGI:1917596, MGI:95827