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Grm3
Gene Detail
Symbol

Name
ID
Grm3
glutamate receptor, metabotropic 3
MGI:1351340
Synonyms
0710001G23Rik, Gprc1c, mGlu3, mGluR3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
3.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:9485541-9725170 bp, - strand
From VEGA annotation of GRCm38

  239630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:651  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRM3
Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm3

Human
homologs
GRM3, glutamate receptor, metabotropic 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2913
neXtProt AC: NX_Q14832

Human Synonyms: GLUR3, GPRC1C, mGlu3, MGLUR3

Human Chr (Location): 7q21.1-q21.2; chr7:86643914-86864879 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection.
 
Interactions
Grm3 interacts with 174 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (10 records)
Data Summary: Results (344)    Tissues (217)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 256
In situ reporter (knock in) 50
RT-PCR 38
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase grm3 ; ZFIN grm3    NEW 
Molecular
reagents
All nucleic(11) cDNA(9) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000054376 (Evidence)
Ensembl Gene Model ENSMUSG00000003974 (Evidence)
Entrez Gene 108069 (Evidence)
UniGene 318966
DFCI TC1585730, TC1604806
DoTS DT.60103829
NIA Mouse Gene Index U005239
Consensus CDS Project CCDS19090.1
International Mouse Phenotyping Consortium Status Grm3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054376 VEGA Gene Model | MGI Sequence Detail 239630 C57BL/6J ±  kb
transcript OTTMUST00000134901 VEGA | MGI Sequence Detail 3049 Not Applicable 
polypeptide OTTMUSP00000071496 VEGA | MGI Sequence Detail 879 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(2366 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR001234 GPCR, family 3, metabotropic glutamate receptor 3
InterPro IPR011500 GPCR, family 3, nine cysteines domain
InterPro IPR028082 Periplasmic binding protein-like I
InterPro IPR001828 Receptor, ligand binding region
Protein Ontology PR:000008265 metabotropic glutamate receptor 3
References
(Earliest) J:21416 Chavis P, et al., The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J Neurosci. 1994 Nov;14(11 Pt 2):7067-76
(Latest) J:218605 Battaglia G, et al., Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. Neurobiol Dis. 2015 Feb;74:126-36
All references(59)
Other
accession IDs
MGD-MRK-10266, MGI:1917596, MGI:95827

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory