Grm2
Gene Detail

Symbol Name ID

Grm2 glutamate receptor, metabotropic 2 MGI:1351339

Synonyms

4930441L02Rik, Gprc1b, mGluR2

Feature Type

protein coding gene

Genetic Map

Chromosome 9

57.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:106644537-106656109 bp, - strand From Ensembl annotation of GRCm38   11573 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm2

Human homologs

Human Homolog		GRM2, glutamate receptor, metabotropic 2
NCBI Gene ID		2912
neXtProt AC		NX_Q14416
Human Synonyms		GLUR2, GPRC1B, mGlu2, MGLUR2
Human Chr (Location)		3p21.2; chr3:51741081-51752629 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene display subtile behavioral modifications and moderate abnormalities in long term depression and EPSP in the hippocampus.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway, glutamate secretion, ...
Component	axon, integral to membrane, ...
Function	calcium channel regulator activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(6) Genomic(1) cDNA(5)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000023192 (Evidence)
Entrez Gene	108068 (Evidence)
DFCI	TC1617630, TC1642062, TC1668146
DoTS	DT.101707458, DT.55257640, DT.91356877, DT.94171076
NIA Mouse Gene Index	U031299
Consensus CDS Project	CCDS52914.1
International Mouse Knockout Project Status	Grm2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023192	Ensembl Gene Model | MGI Sequence Detail	11573	C57BL/6J
transcript	ENSMUST00000023959	Ensembl | MGI Sequence Detail	3320	Not Applicable
polypeptide	ENSMUSP00000023959	Ensembl | MGI Sequence Detail	872	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(91 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000337	GPCR, family 3
InterPro	IPR017979	GPCR, family 3, conserved site
InterPro	IPR017978	GPCR, family 3, C-terminal
InterPro	IPR000162	GPCR, family 3, metabotropic glutamate receptor
InterPro	IPR001458	GPCR, family 3, metabotropic glutamate receptor 2
InterPro	IPR011500	GPCR, family 3, nine cysteines domain
Protein Ontology	PR:000008264	metabotropic glutamate receptor 2

References

(Earliest) J:24606 Wallace ME, New linkage and independence data for Ruby and Jerker in the mouse. Heredity. 1958;12:453-62
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(52)

Other accession IDs

MGD-MRK-10265, MGI:1921233, MGI:95826