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Grm2
Gene Detail
Symbol

Name
ID
Grm2
glutamate receptor, metabotropic 2
MGI:1351339
Synonyms
4930441L02Rik, Gprc1b, mGluR2
Feature Type
protein coding gene
Genetic Map
Chromosome 9
57.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:106644537-106656109 bp, - strand
From Ensembl annotation of GRCm38

  11573 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: metabotropic glutamate receptor-like protein
Gene Tree: Grm2

Human
homologs
Human Homolog   GRM2, glutamate receptor, metabotropic 2
NCBI Gene ID 2912
neXtProt AC  NX_Q14416
Human Synonyms  GLUR2, GPRC1B, mGlu2, MGLUR2
Human Chr (Location)  3p21.2; chr3:51707065-51718613 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for disruptions in this gene display subtile behavioral modifications and moderate abnormalities in long term depression and EPSP in the hippocampus.
 
Interactions
Grm2 interacts with 99 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) Genomic(1) cDNA(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000023192 (Evidence)
Entrez Gene108068 (Evidence)
DFCITC1668146, TC1642062, TC1617630
DoTSDT.55257640, DT.101707458, DT.91356877, DT.94171076
NIA Mouse Gene IndexU031299
Consensus CDS ProjectCCDS52914.1
International Mouse Knockout Project StatusGrm2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023192 Ensembl Gene Model | MGI Sequence Detail 11573 C57BL/6J ±  kb
transcript ENSMUST00000023959 Ensembl | MGI Sequence Detail 3320 Not Applicable 
polypeptide ENSMUSP00000023959 Ensembl | MGI Sequence Detail 872 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(129 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000337 GPCR, family 3
InterPro IPR017979 GPCR, family 3, conserved site
InterPro IPR017978 GPCR, family 3, C-terminal
InterPro IPR000162 GPCR, family 3, metabotropic glutamate receptor
InterPro IPR001458 GPCR, family 3, metabotropic glutamate receptor 2
InterPro IPR011500 GPCR, family 3, nine cysteines domain
Protein Ontology PR:000008264 metabotropic glutamate receptor 2
References
(Earliest) J:24606 Wallace ME, New linkage and independence data for Ruby and Jerker in the mouse. Heredity. 1958;12:453-62
(Latest) J:218605 Battaglia G, et al., Activation of mGlu3 metabotropic glutamate receptors enhances GDNF and GLT-1 formation in the spinal cord and rescues motor neurons in the SOD-1 mouse model of amyotrophic lateral sclerosis. Neurobiol Dis. 2015 Feb;74:126-36
All references(62)
Other
accession IDs
MGD-MRK-10265, MGI:1921233, MGI:95826

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory