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Grm2 Gene Detail
Summary
  • Symbol
    Grm2
  • Name
    glutamate receptor, metabotropic 2
  • Synonyms
    4930441L02Rik, Gprc1b, mGluR2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351339
    NCBI Gene: 108068
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:106644534-106656109 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.98 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351339
protein coding gene Chr9:106643095-106656109 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035241
protein coding gene Chr9:108459354-108472295 (-)
A/J MGP_AJ_G0035220
protein coding gene Chr9:104528508-104541453 (-)
AKR/J MGP_AKRJ_G0035152
protein coding gene Chr9:107136528-107149473 (-)
BALB/cJ MGP_BALBcJ_G0035214
protein coding gene Chr9:104215191-104228152 (-)
C3H/HeJ MGP_C3HHeJ_G0034924
protein coding gene Chr9:107550066-107564513 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035734
protein coding gene Chr9:111451289-111464214 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032632
protein coding gene Chr9:102015548-102028495 (-)
CAST/EiJ MGP_CASTEiJ_G0034235
protein coding gene Chr9:107468871-107481941 (-)
CBA/J MGP_CBAJ_G0034892
protein coding gene Chr9:115404065-115417065 (-)
DBA/2J MGP_DBA2J_G0035053
protein coding gene Chr9:103993563-104006743 (-)
FVB/NJ MGP_FVBNJ_G0035001
protein coding gene Chr9:102773179-102786130 (-)
LP/J MGP_LPJ_G0035129
protein coding gene Chr9:108674113-108687062 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035040
protein coding gene Chr9:116976773-116989720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035755
protein coding gene Chr9:107398961-107411906 (-)
PWK/PhJ MGP_PWKPhJ_G0033942
protein coding gene Chr9:104296711-104309968 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033777
protein coding gene Chr9:107470328-107486244 (-)
WSB/EiJ MGP_WSBEiJ_G0034356
protein coding gene Chr9:107300626-107313608 (-)



Homology
more
  • Human Ortholog
    GRM2, glutamate metabotropic receptor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRM2, glutamate metabotropic receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLUR2, GPRC1B, mGlu2, MGLUR2
  • Links
    NCBI Gene ID: 2912
    neXtProt AC: NX_Q14416
    UniProt: Q14416

  • Chr Location
    3p21.2; chr3:51707033-51718616 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display subtile behavioral modifications and moderate abnormalities in long term depression and EPSP in the hippocampus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 108068 NCBI Gene Model | MGI Sequence Detail 11576 C57BL/6J ±  kb
transcript NM_001160353 RefSeq | MGI Sequence Detail 3338 C57BL/6  
polypeptide Q14BI2 UniProt | EBI | MGI Sequence Detail 872 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 7
    Genomic 2
    cDNA 5

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10265, MGI:1921233, MGI:95826
References
more
  • Summaries
    All 72
    Developmental Gene Expression 10
    Gene Ontology 10
    Phenotypes 23
  • Earliest
    J:24606 Wallace ME, New linkage and independence data for Ruby and Jerker in the mouse. Heredity. 1958;12:453-62
  • Latest
    J:264962 Olszewski RT, et al., NAAG Peptidase Inhibitors Act via mGluR3: Animal Models of Memory, Alzheimer's, and Ethanol Intoxication. Neurochem Res. 2017 Sep;42(9):2646-2657

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory