Sequence Detail

ID/Version

Q14BI2 (UniProt | EBI)

Last sequence update: 2007-10-02
Last annotation update: 2025-04-09

Sequence description from provider

RecName: Full=Metabotropic glutamate receptor 2; Short=mGluR2;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 872 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Grm2	glutamate receptor, metabotropic 2	64	100	4	8

Sequence references in MGI

J:21416 Chavis P, et al., The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells. J Neurosci. 1994 Nov;14(11 Pt 2):7067-76
J:34606 Yokoi M, et al., Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 1996 Aug 2;273(5275):645-7
J:97172 Morishima Y, et al., Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4170-5
J:136808 Gonzalez-Maeso J, et al., Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 2008 Mar 6;452(7183):93-7
J:308957 Moreno JL, et al., Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A.mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem. 2012 Dec 28;287(53):44301-19