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Trp53bp1
Gene Detail
 Symbol
Name
ID
Trp53bp1
transformation related protein 53 binding protein 1
MGI:1351320
Synonyms 53BP1, p53BP1
Feature Type protein coding gene
Genetic Map
Chromosome 2
60.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:121193281-121271407 bp, - strand
From VEGA annotation of GRCm38

  78127 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4137  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Trp53bp1

Human
homologs
Human Homolog TP53BP1, tumor protein p53 binding protein 1
NCBI Gene ID 7158
neXtProt AC  NX_Q12888
Human Synonyms  53BP1, p202
Human Chr (Location)  15q15-q21; chr15:43407214-43510509 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Chemically induced (ENU)(1) Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutations in this gene result in growth retardation, immunodeficiency, thymic hypoplasia, and increased incidence of thymic lymphomas.
 
Interactions
Trp53bp1 interacts with 403 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component chromosome, chromosome, centromeric region, ...
Function damaged DNA binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (96)    Tissues (16)    Images (21)
Theiler Stages: 23
Assay TypeResults
RNA in situ 96
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000015973 (Evidence)
Ensembl Gene ModelENSMUSG00000043909 (Evidence)
Entrez Gene27223 (Evidence)
PDB1SSF
Consensus CDS ProjectCCDS50684.1, CCDS71125.1
International Mouse Knockout Project StatusTrp53bp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015973 VEGA Gene Model | MGI Sequence Detail 78127 C57BL/6J ±  kb
transcript OTTMUST00000038042 VEGA | MGI Sequence Detail 9621 Not Applicable 
polypeptide OTTMUSP00000017066 VEGA | MGI Sequence Detail 1969 Not Applicable 

For the selected sequences
All sequences(116) RefSeq(18) UniProt(14)
Polymorphisms SNPs within 2kb(435 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR014722 Ribosomal protein L2 domain 2
InterPro IPR015125 Tumour suppressor p53-binding protein-1 Tudor domain
Protein Ontology PR:000016558 tumor suppressor p53-binding protein 1
References (Earliest) J:36914 Datta B, et al., p202, an interferon-inducible modulator of transcription, inhibits transcriptional activation by the p53 tumor suppressor protein, and a segment from the p53-binding protein 1 that binds to p202 overcomes this inhibition. J Biol Chem. 1996 Nov 1;271(44):27544-55
(Latest) J:206106 Park E, et al., Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice. Mol Cell Biol. 2013 Nov;33(22):4360-70
All references(93)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory